Ben Reisman MD PhD
@BenjaminReisman
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Onc Fellow @Hopkins_HemOnc via @OslerResidency + @VanderbiltMSTP • chemical biologist ⚗️
Baltimore, MD
Joined January 2012
I’m excited to share my thesis work on the mechanism of action of the apoptolidins in leukemia, out today @nchembio. 1/n https://t.co/7SFSDIcEql
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I doubted studies claiming ICI infusion timing mattered (ICI half-life = weeks!). Afternoon patients surely differ in unmeasurable ways. But now a randomized trial ➡️morning ICI does better… 🤔
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Today in @Nature we report a systematic strategy to activate & identify gene sets in plants. We identify 8 new genes from the yew tree's Taxol biosynthetic pathway, enabling us to engineer tobacco with 17- & 20-gene pathways to Taxol precursors baccatin III and dBz-deoxy-Taxol. a
nature.com
Nature - An approach that combines single-nucleus RNA sequencing and multiplexed perturbation identifies genes that enable the biosynthesis of direct precursors of the anti-cancer drug Taxol, whose...
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1/ Our new review is out today in Nature Reviews Cancer—on why therapeutic cancer vaccines are finally gaining traction after decades of setbacks. 🔗 https://t.co/tsU0hghgJm w/ @NeehaZaidi @DrLizJaffee Key takeaways below
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🧫 A practical protocol for multiplexed single-cell cytometry bridges #chemicalbiology and #cellbiology—empowering both novices and experts to explore functional assays with high-throughput precision. 👉 https://t.co/1HSxyKl3qs
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📢 New KFW Lab paper out now in @ScienceAdvances! 📢 We show that AML cells resist chemotherapy by reversing the ATP synthase reaction—supporting oxidative metabolism and maintaining mitochondrial membrane potential. 🔬🧬 👉
science.org
Unlike healthy blood cells, AML cells reverse the ATP synthase reaction to support oxidative metabolism and resist chemotherapy.
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We are delighted to share our latest findings today in @Nature. We describe cardiogenic regulation of sleep after cardiac injury. “Myocardial infarction augments sleep to limit cardiac inflammation and damage” https://t.co/ip6psmJBZ2
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👋 @WashUHeme is recruiting!!!🤩 We are seeking physician-scientist, clinical & research faculty candidates to join our expanding #HemeDreamTeam! More details here: https://t.co/eMjx7O35vZ
https://t.co/LZ8G3bNHN7
https://t.co/6dTE4tC3oL
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@WUDeptMedicine
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TP53: - Discovered 45 years ago, most cited gene all time - No therapies - 500 million people currently living will die of TP53 mutant cancers without new therapies Our Preprint: - A general strategy for TP53 missense mutant cancers (majority) with prototype small molecules
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A single SNP in ~10% of US African Ancestry individuals causes a systematic decrease in HbA1c and a dramatic under treatment of diabetes. In @NatureMedicine led by @JosephBreeyear @JackieHellwege @genepiman_giri @toddledwards @VUMCDiscoveries
https://t.co/L2dWxyUYmV
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Nature research paper: Obesity induces PD-1 on macrophages to suppress anti-tumour immunity
nature.com
Nature - A study demonstrates that metabolic signalling and inflammatory cues associated with obesity selectively induce expression of PD-1 on tumour-associated macrophages to suppress anti-tumour...
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Excited to share 2 preprints, together showing how mechanisms of a molecular glue & E3 ligase cancer mutations serendipitously converge to cause neomorphic protein degradation in distinct contexts. Highlights below: 1/17 #1: https://t.co/8UA8tJ2iti
#2:
biorxiv.org
Cancer mutations can create neomorphic protein-protein interactions to drive aberrant function[1][1]. As a substrate receptor of the CULLIN3-RBX1 E3 ubiquitin ligase complex, KBTBD4 is recurrently...
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My latest story is about how a very old and very cheap drug has been quietly revolutionizing bone-marrow transplants. (1/3)
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#Thayer team supporting #SaySarcoidosis #Awareness Campaign #FindACure! @OslerResidency and they #challenge the #Barker firm to #SaySarcoidosis
#sarcoidosis @JohnsHopkinsDOM @HopkinsPCCM @jhrheumatology @mwsharp5 @soupvector @sanjayvdesai
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Beyond excited to share my first paper from my PhD @DPhaz Lab @IMS_MRL now out in @embojournal! Special thanks to Sam from @TVPLab and @dougall_norris for co-leading this project with me. We found that many cell culture models, despite living in 18% oxygen, are hypoxic! 🧵below:
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TET2 clonal hematopoiesis is enriched among individuals receiving solid organ transplantation. While this didn't predict transplant outcomes, whether it plays a role in the ultimate transplant indication requires further study https://t.co/1axLKJ50Nq
@AACR @AlexSilverMSTP
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My lab is hiring postdocs to study aneuploidy's role in cancer! We're applying next-gen chromosome engineering approaches to uncover how gene dosage imbalances impact drug sensitivity, metabolism, immune evasion, and more. Send me your CV+cover letter if interested. Please RT!
Check out our new study in @ScienceMagazine, where we take on a 100-year-old debate: what’s the role of aneuploidy in cancer? We discovered that genetically removing extra chromosomes blocks cancer growth - a phenomenon we call “aneuploidy addiction”.
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Proud to share our findings on Primary and Secondary Graft Failure in patients receiving AlloHSCT + PTCy as GVHD prophylaxis A very special thanks to my grand-ACS Dr. Alex Ambinder for his awesome mentorship https://t.co/BgRHqi1jKS
astctjournal.org
Although the incidence of graft failure (GF) after allogeneic hematopoietic cell transplant (alloHCT) is low, it is associated with significant morbidity and mortality as a result of prolonged...
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A new study from @AlexBickMDPhD & @FerrellLabVUMC labs led by incredible @brettheimlich, Pawan Bhat & @alyssa_c_parker! Comprehensive multi-omic profiling of 66968 single cells unveils that TET2 & DNMT3A mutations in Clonal Hematopoiesis drive distinct inflammatory pathways,
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