
Conor McClune
@conor_mcclune
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@DamonRunyon Postdoc @Stanford with @Sattely_lab & @fordycelab Plant chemistry, synthetic biology, and everything in between. Formerly Voigt & Laub labs @MIT
Stanford, CA
Joined April 2016
Today in @Nature we report a systematic strategy to activate & identify gene sets in plants. We identify 8 new genes from the yew tree's Taxol biosynthetic pathway, enabling us to engineer tobacco with 17- & 20-gene pathways to Taxol precursors baccatin III and dBz-deoxy-Taxol. a.
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It makes sense that skin microbes would have an intimate relationship with our immune cells. But engineering these bugs into topical vaccines still feels like sci-fi. Congrats @DjenetBousbaine!.
It’s truly an honor to receive this year’s @ScienceMagazine Noster Microbiome prize. Here’s my essay on how we can engineer skin microbes to build vaccines:.
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Pithy coverage of our recent work elucidating and reconstituting how yew trees synthesize Taxol . #synbio.
Plant Science Research Weekly -- Elucidation and recreation of the biosynthetic pathway for taxol (Nature) @conor_mcclune (Summary by Mary Williams) . #PlantaePSRW.
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RT @plantae_org: Plant Science Research Weekly -- Elucidation and recreation of the biosynthetic pathway for taxol (Nature) @conor_mcclune….
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RT @chofski: What to agument your favourite protein with new functionalities? We've got a #biodesign workflow to help with that! In work le….
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RT @lpachter: This week in academia, a not so short🧵. 1. Staff reductions and other cost cutting measures coming to Brown University ht….
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RT @JohnStreicher1: My NIDA grant renewal is almost 2 months late and I’m going to have to start firing my students and staff. Not a lot of….
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RT @DamonLisch: Wise words from my friend John Fowler. Gutting funding basic research is a profoundly bad idea. Shocking that this has been….
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RT @SynBio1: Now that they've ported the biosynthetic pathway for taxol into tobacco plants you can finally get cancer and treat cancer at….
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Great article in today’s Stanford Report on our recent work deciphering how yew trees produce Taxol. @Sattely_lab @ctliu629
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RT @cenmag: Baccatin III is a key precursor for the chemotherapy drug Taxol, and scientists have now figured out how it’s made in yew trees….
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A nice overview in @cenmag of our paper identifying how yew trees synthesize the cancer drug Taxol: .
Today in @Nature we report a systematic strategy to activate & identify gene sets in plants. We identify 8 new genes from the yew tree's Taxol biosynthetic pathway, enabling us to engineer tobacco with 17- & 20-gene pathways to Taxol precursors baccatin III and dBz-deoxy-Taxol. a.
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RT @Nature: ‘Missing’ genes needed for the biosynthesis of a natural anticancer drug have been discovered by perturbing and analysing indiv….
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RT @Nature: Nature research paper: Discovery of FoTO1 and Taxol genes enables biosynthesis of baccatin III.
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A nice overview of our new paper in @ScienceMagazine news.
"Paclitaxel is one of the most important drugs in the fight against #cancer.". It is derived from yew trees, but newly discovered plant genes could lead to cheaper synthesis of Taxol precursor in yeast cells. #Science #Genomics #Biology #Biochemistry.⏯️
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Thank you to @Franke_Lab for his eloquent overview in @NatureNV News & Views on our Taxol @nature paper. He deftly articulates the history of this valuable drug, the longstanding biochemistry challenge we tackled, and how we broke it down.
Today in @Nature we report a systematic strategy to activate & identify gene sets in plants. We identify 8 new genes from the yew tree's Taxol biosynthetic pathway, enabling us to engineer tobacco with 17- & 20-gene pathways to Taxol precursors baccatin III and dBz-deoxy-Taxol. a.
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This work was only possible with generous funding from @HHMINEWS , a @DamonRunyon fellowship and a @NIH_NCCIH K99. Thank you!.
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