Daniel Fazakerley
@DPhaz
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Group leader at @IMS_MRL researching insulin action and glucose transporter traffic.
Cambridge, England
Joined August 2009
Please check out Liv's preprint and thread below!
Very excited to finally share our work using subcellular proteomics to look at insulin-stimulated protein movement in adipocytes! 🧵below: (1/5) https://t.co/ziznyembiL
@DPhaz @IMS_MRL
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Our next Seminar Series talk is this Friday, at 13:00! Our speaker is Dr Natalie Krahmer, whose talk is on Elucidating the Cell Architecture of Metabolic Liver Disease via Spatial Proteomics 💊 More info here: https://t.co/Rg2RVlL26N
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Genetic impairment of ketone body signalling is a prevalent contributor to human metabolic dysfunction https://t.co/fm0tpkFBKn Working with our great collaborators at Pfizer we have uncovered a common genetic contributor to metabolic ill health/
medrxiv.org
Emerging evidence that circulating levels of key metabolic intermediates are sensed by a range of G-Protein Coupled receptors (GPCRs) is providing critical new insights into the control of systemic...
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Interested in a pretty cool postdoc project with Dr @HenningLanger and I? 🔥
Hey Muscle And Metabolism Folks on Twitter, @LykkeSylow and I are looking for a Postdoc who is interested in applying for a prestigious @DDEA_Denmark fellowship with us. More details in the picture attached. Please share widely! @MYOTWlTTER
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Uri is a brilliant and creative scientist working on super important and challenging research questions - he’s also a bloody nice guy. I hope his message spreads wide and far to highlight the absolute madness many of our US colleagues are going through at the moment. Please RT 🙏
My lab’s 5-year NIH R01 grant, awarded to study gene therapy for hearing loss, was abruptly terminated. I want to share how this action has been incredibly harmful and disruptive, not just to my lab, but to the scientific process itself. 1/15
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Excited to share some of our work on ubiquitin at this seminar!
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Thanks to our amazing collaborators: @TVPLab @ThomasKriegLab @Mito_Redox @DPhaz and @AstraZeneca teams. Proud of this @TheBHF -supported science!
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🚨 New paper out from us, reveals a novel role for mitochondrial RET-ROS in #HFpEF. 🧬 ND6 mutation ➡️ 🫀 Hypertrophy 💔 Diastolic dysfunction 🏃♂️ ↓ Exercise capacity 💪 ↑ Lean mass 🍩 HFD worsened metabolism ✅ Exercise reversed many effects! https://t.co/bBGBQR8NoA
journals.physiology.org
Central to the development of heart failure with preserved ejection fraction (HFpEF) is the redox disruption of metabolic processes; however, the underlying mechanisms are not fully understood. This...
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🚨We're hiring! Come join us in Belfast at @WWIEM_QUB 🔬 We're looking for a postdoc to help uncover the mechanism behind a novel genetic cause of heart failure, funded by @TheBHF. Apply here👉 https://t.co/Itm4eafmlU Questions? Reach out via X/LinkedIn/Email! @ProfDavidGrieve
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Check out our latest paper published in Diabetes @ADA_DiabetesPro Analysis of multiple insulin actions in single muscle fibres from insulin resistant mice reveals selective defect in endogenous GLUT4 translocation
diabetesjournals.org
Accurate measurement of GLUT4 translocation is crucial for understanding insulin resistance in skeletal muscle, a key factor in the development of metaboli
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🚨 pleased to share a new preprint made possible through a great collaboration with the @melissa_skala & @SeanPalecek labs! can medium composition impact the behavior of hPSC-derived cardiomyocytes? Andy and Aaron co-led efforts to tackle this Q w/HPLM! https://t.co/s71Ygb2aVm
biorxiv.org
Maturing human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) in vitro is critical for advancing drug discovery and cardiotoxicity screening applications of these cells. However, the...
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excited for a weekend of great science #ASBMB25! if you're in CHI, I encourage you to check out a session that @Derpology & I co-organized, Sat @ 930 (W176): https://t.co/CVSoiKpYku +a short talk from Kyle (Sun @ 9, W178), and posters from Kim, Kyle, & Gavin (Sun @ 430, W375c)!
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Interested in undertaking a PhD to contribute to the understanding of the links between insulin resistance and cardiovascular disease? Apply to join my lab at the RVC with this fully-funded PhD studentship.
🎓 Fully-funded PhD studentship available. Apply now for a PhD studentship to learn from experts who produce cutting-edge research and are published in top academic journals. Fully-funded for UK 'Home' students. ➡️ https://t.co/CxdfrIdVJS
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@IMS_MRL @Cambridge_Uni full-time taught MPhil in Obesity, Endocrinology and Metabolism for 2025/2026 Application deadline 4th April!!! High quality postgrad training in physiology & pathophysiology of energy balance & metabolism. 🛜 https://t.co/4BajfvRzOe
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We have a postdoc position available in our team to undertake a UKRI-funded project to develop a new cultured skeletal muscle model for studying glc metabolism and insulin action. https://t.co/jnObCCq8vh
@IMS_MRL Please RT. Please email if interested.
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happy to share our forum now online @Cell_Metabolism! fun for us (@guytochondria & myself) to collaborate with @DPhaz @joycelyntsi, and Sam in putting together what we hope will be a useful piece for the broad metabolism community re: in vitro modeling! https://t.co/MG5UkQPko7
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Excited to share our opinion piece on why current standard cell culture practices deserve more consideration - with implications on cell metabolism and beyond! We focus in particular on nutrient and oxygen availability. A pleasure to work with @JasonRCantor lab! @DPhaz @IMS_MRL
happy to share our forum now online @Cell_Metabolism! fun for us (@guytochondria & myself) to collaborate with @DPhaz @joycelyntsi, and Sam in putting together what we hope will be a useful piece for the broad metabolism community re: in vitro modeling! https://t.co/MG5UkQPko7
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Anyone interested in working with me @IMS_MRL @Cambridge_Uni on how AMGEN's new obesity drug works? I have a 3 year postdoc position available! Deadline March 31st! please share
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