Shyam Prabhakar Lab
@shyam_lab
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Associate Director Spatial and Single Cell Systems @astar_gis. Genomics: algorithms, disease markers & mechanisms, genetic diversity [email protected]
Singapore
Joined November 2019
Want to join a global consortium using #singlecell technologies to understand human diversity? Are #AI and #MachineLearning your #s? Come to Singapore! We're looking for leaders to drive v1 of the Human Diversity Atlas within the #HumanCellAtlas.
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RT @NiranjanTW: Our study developing a skin metatranscriptomics protocol is now out in @NatureBiotech!. We finally have the ability to studβ¦.
nature.com
Nature Biotechnology - Skin metagenomic and metatranscriptomic analysis shows divergence between microbial abundance and activity.
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RT @DrGopalIyer: During which time we could show effective response to vaccines (Covid mRNA) and tumor dissociates which was really amazingβ¦.
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RT @DrGopalIyer: Using our previous system for tumor explant cultures PhaseX, we were able to sustain lymph nodes tβ¦.
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RT @slavov_n: Tools have long propelled discoveries:. "πππ‘βπππ π‘ππππ π π ππ’πβ π‘π π‘βπ πππ£ππππππππ‘ ππ ππππ€πππππ ππ π‘βπ ππππππππ‘πππ ππ π πππ€ ππβ¦.
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Important study of bias in peer review, analyzing 204,000 papers at 60 physical science journals. Researchers in big counties have more same-country reviewers, which subtly raises their likelihood of acceptance (1% higher probability). Wonder how big this bias is in biologyβ¦.
βGeographical diversity of peer reviewers shapes author success,β say researchers.
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RT @asgari_samira: I am beaming with pride π€© Well deserved @abhijith_biji! . If you are going to #ashg25 make sure to attend Abhiβs talk anβ¦.
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RT @NatureMedicine: RESEARCH. In cohort B of the phase 2 SWOG S1512 trial, pembrolizumab monotherapy in patients with unresectable desmoplaβ¦.
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RT @carninci: 1/.π₯ New study from the @SGustincich lab (proud to be part of it): we uncover surprising interchangeability between RNA elemeβ¦.
academic.oup.com
Abstract. Sequences in the 5β²-untranslated regions of cellular and viral mRNAs can function as internal ribosome entry sites (IRESs), driving cis-acting tr
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Nice to see data-driven definitions of disease subtypes. And not surprising I guess that MS subtypes lie on a phenotypic continuum, i.e. no clear dividing line. But of course clinicians will presumably still need to discretize for treatment selection.
π¨ Paradigm shift in #MultipleSclerosis π¨.New study in Nature Medicine shows MS is not fixed subtypes but a dynamic continuum of states across 4 dimensions: disability, brain damage, relapses & silent inflammation. π Read: #MS #Neurology #AI
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RT @kitazawa_taro: Please RP. We are thrilled to announce that our labβs first preprint is out!.βWhole-genome single-cell multimodal historβ¦.
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A top AI researcher in Singapore explained it to me this way: βWe use AI to publish papers, but when a company pays us to solve a problem, we use linear regression because itβs more reliable.β.
Think you need deep learning for every bioinformatics problem? Think again. Most of the time, simpler models win. π§΅
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RT @BrendanMSwain: @Andrei_Tarkhov Some colleagues asked the same question, and we found that the metrics used to measure the models make aβ¦.
arxiv.org
Recent benchmarks reveal that models for single-cell perturbation response are often outperformed by simply predicting the dataset mean. We trace this anomaly to a metric artifact:...
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RT @slavov_n: The heterogeneity of HeLa cell-lines undermines reproducibility. HeLa cells were obtained without informed consent. ==> Rβ¦.
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As researchers, we often rail against unreasonable and irrational editors. And yes, theyβre human and they do err. But letβs remember that editors base their judgments and their worldview on opinions that we researchers provide. If theyβre misguided, itβs because we are too.
Correct. In papers and grants.
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RT @victornizet: one small consolation of turning 60 this year is the ability to submit to ππππππ family journals β sure theyβre low impactβ¦.
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RT @astar_gis: From Seoul and Sydney to Singapore β join the global conversations on RNA and population genomics. As part of the Genome Inβ¦.
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RT @slavov_n: I think academia needs more public discussions focussed on constructive criticism. Such discussions are hard. Much harder thβ¦.
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RT @GaryMarcus: My work here is truly done. Nobody with intellectual integrity can still believe that pure scaling will get us to AGI. GPTβ¦.
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