Chris Timmermann
@neurodelia
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Postdoc @ImperialCollege Centre for psychedelic research. Head of DMT Research Group. Neuroscience | Psychology | Phenomenology | Musician
Joined August 2015
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Are you going to a meditation retreat this spring or summer? Sign up for our global prospective survey studying the effects of meditation!
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Our DMT Neuroimaging paper is out now in
@PNASnews
TLDR: DMT is associated with a dysregulation of the developmentally/evolutionary recent cortex and linked to reduced alpha power, increased entropy, and 5-HT2AR density.
with
@RCarhartHarris
et al.
🧵
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The published version of our paper Psychedelics alter Metaphysical Beliefs is now live in Scientific Reports 1/n
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Our new feature review is now published in
@TrendsCognSci
‘A Neurophenomenological (NP) approach to non-ordinary states of consciousness (NSCs): hypnosis, meditation, and psychedelics’ (a thread)
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Our new paper showing the psychological and physiological effects of extended DMT infusions (for 30 minutes) has just been published. Work led by the great
@lisaxiaolu
from our DMT Research Group at the Centre for Psychedelic Research
@Imperial_PRG
1/n
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Our first brain imaging paper of the effects of DMT is out! . Thanks to all involved!
@RCarhartHarris
@LeorRoseman
@raphamilliere
@ProfDavidNutt
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Today, our DMT Research Group at the
@Imperial_PRG
completed the first EEG hyperscanning session with 2 people being dosed with DMT at the same time. Led by
@_kategodfrey
+
@tommaso_barba
. Much gratitude to
@antonbilton
enabling it and Jeremy Gardner for support. More soon...
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Our research covered by The Guardian
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See Imperial College's official press release for an easier-to-follow take on our recent findings of the DMT Neuroimaging study
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Do psychedelics shift beliefs concerning the nature of reality? We explore this in our latest preprint with
@KettnerHannes
@chrisletheby
@RCarhartHarris
@_fernando_rosas
@LeorRoseman
1/n
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80 years ago marks the first LSD trip. The begining of the mainstream story of psychedelics in the West. Hoffman’s invention and accidental trip is appropriately filled with mystery and mythology
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Our new paper 'DMT models the near-death experience' is out now!
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Our first preprint of our work extending the DMT peak experience for 30 minutes! This work led by the great
@lisaxiaolu
shows:
1. Different dose regimens to extend DMT
2. That DMT extended is safe
3. Some form of psychological tolerance develops over time
New preprint alert💥 Psychological and physiological effects of extended DMT
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Evidence for ritual DMT use 1000 years ago found in Bolivia
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1/ New paper out today on
@SciReports
We explored the effects of DMT on mental health outcomes in healthy volunteers and its relationship to the acute experience
with
@RCarhartHarris
@ProfDavidNutt
@RickZeifman
@DavidErritzoe
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Truly honoured to have been awarded the Varela Award by
@MindandLifeEU
to study ego-dissolution induced by 5-MeO-DMT and different meditation practices . Looking forward to exciting work ahead with
@Antoine_Lutz
@tommaso_barba
@JWSanders_
@Imperial_PRG
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If you are at
#ASSC25
and interested in the interface between psychedelics and consciousness come to poster sessions from our group with
@RCarhartHarris
@LeorRoseman
@_fernando_rosas
and others. First,psychological effects induced by extended infusion of DMT led by Lisa Luan 1/2
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Prosocial behaviour of octopuses on MDMA... 'far out' falls short...
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Thank you
@mind_europe
for making a live conference happen again and the recognition of our work
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Psychedelics Can Change Your View on the Nature of Reality
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Planning to go to a meditation retreat? Please help us understand the psychological effects and impact of these experiences by signing up for this prospective survey here
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New paper: Neural network models for DMT-induced visual hallucinations by
@Michaelschart
to which I contributed. Using deep neural networks we hope to illustrate psychedelic phenomenology and explore serotonergic balancing of external vs internal info
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I wrote a piece in Psychology Today covering recent research on how psychedelics alter worldviews and metaphysical beliefs and possible implications for mental health
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Curious findings here. Low doses of LSD increase neural entropy but no change in alpha power. Given that in high doses alpha drop is the most replicated psychedelic neuro finding this is somewhat suggestive that alpha power (and not so much entropy) related to the trip
Excited this paper from my postdoc at UChicago is out! “Microdoses” of LSD increase complexity, but not other drugs, even at doses that induce altered states (AS). AS was instead related to ⬇️ alpha. How might changes in entropy vs alpha predict outcomes?
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In our latest study, LSD reduced the neuronal response to novel stimuli, while increasing it for familiar stimuli and connectivity results showed consistent findings, indicating how mechanisms of perceptual learning might be affected by psychedelics
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Humberto Maturana, who introduced the notion of autopoiesis with Francisco Varela (and so much more) has died. An invaluable contribution to science and a legacy which will probably keep giving for many years to come
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If you are attending
#ICPR2022
this week check out presentations from our group doing work with DMT for consciousness research from
@Imperial_PRG
:
1) Talk by Lisa Luan (PhD cand.): Using continuous infusions to extend the DMT experience. Friday 9:55
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Lisa Luan, showing preliminary results from out extended DMT infusion experiments
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Understanding the effects of serotonin in the brain through its role in the gastrointestinal tract … with an intriguing analogy of psychedelics as cognitive laxatives :)
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Interested in what goes on in our DMT studies? Check below a podcast episode with
@ProfDavidNutt
and a study participant for the
@Drug_Science
podcast
For the first time,
#DMT
is being studied in an fMRI and EEG to elucidate why and how this drug produces vivid dreamlike states of consciousness and simulated near-death experiences.
Download the latest episode of the Drug Science podcast, right here ->
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Massive gratitude also to the courageous anonymous participants who gracefully volunteered in this DMT study. I cannot stress enough the importance of careful screening, support, respectful presence, etc. needed to make sure everyone has a safe experience in these studies n/n
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Thank you
@AnatomyLab
for making this detailed recap of our work this year exploring the effects of DMT in the brain via simultaneous EEG-fMRI
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Our work with the DMT Redesrch Group at
@Imperial_PRG
was recently featured in the
@sciencevs
podcast. Listen here
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Fascinating fMRI study of immersive meditation (e.g., Jhana) states by
@MatthewSacchet
et al.
Delighted to share our new paper in Cerebral Cortex (
@OxUniPress
):
Intensive whole-brain 7T MRI case study of volitional control of brain activity in deep absorptive meditation states
This is the most rigorous study of advanced concentration meditation (jhana)
🧠🧘♀️🔬
🧵
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New preprint with David Dupuis and Rosalind Watts (). We outline some ethical challenges associated with the mediation and validation of psychedelic-induced noetic insights and revelations in therapeutic, neo-shamanic and research contexts 1/2
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December 11th, we will have
@RCarhartHarris
, Roland Griffiths and
@KatrinPreller
for an online seminar, discussing bridges between psychedelics, neuroscience, consciousness and mental health. Register here
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Do psychedelics shift beliefs concerning the nature of reality? We explored this and found psychedelics tended to shift beliefs away from physicalism and towards panpsychism. Importantly, some of these findings were correlated with mental health outcomes 2/n
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We recruited 20 healthies for the first resting-state EEG-fMRI study of DMT. In a placebo-controlled counterbalanced design, 20mg of IV DMT fumarate induced wide-ranging experiences: strong visuals, alternate ‘dimensions’, ‘entity encounters’, disembodiment, 'mystical' states 2/n
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Some cool stuff here with the first pharmahuasca (synthetic DMT+MAOI) study ever done
Finally! The publication of our first dose-finding DMT+harmine study in humans is out! Happy to finally share some of our work with you all 🌿 Congrats to Dario and the whole team 🤗
✨💕🥳
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Psilocybin induces rapid and persistent growth of dendritic spines in ...
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A nice summary of our findings can be found here 3/n
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Planning to go to a meditation retreat this summer? Then please join our prospective survey studying the nature and impact of these experiences. Join here
@Imperial_PRG
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1/17 of my country on the streets. An inspiring and beautiful sight
In Chile, a country of around 17 million people, more than 1 million people r out in the streets of capital Santiago protesting neoliberalism and the US-friendly govt's repression of protest. The Western media are curiously silent about the scale of the uprising.
#ChileDesperto
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Then, our recently published work on the effects of psychedelics on metaphysical beliefs 2/2
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Evidence for the importance of therapeutic alliance in MDMA theray for PTSD. Congrats
@RickZeifman
Nice to be able to share our paper on the importance of therapeutic alliance in MDMA-assisted psychotherapy for posttraumatic stress disorder
Grateful to have co-authored with
@WagnerAnneC
@KettnerHannes
@BWe1ss
, Stephen Ross, Michael and Ann Mithoefer
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Congratulations
@RCarhartHarris
and everyone else involved for this MASSIVE achievement
Trial of Psilocybin versus Escitalopram for Depression | NEJM
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Our new paper is finally online! LSD, neural adaptation, connectivity and predictive coding
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Here is a nice piece on our recent DMT near-death experience recent findings in Newsweek
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En el Departamento de Física, Universidad de Buenos Aires. Gracias
@ETagliazucchi
por la invitación!
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Promising results from a pilot of ibogaine therapy for TBI
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In EEG, we found DMT-induced reduced alpha and backward waves (possibly encoding priors), increased forward waves, delta, and gamma power. Increased entropy (LZ) was linked to the richness of experience supporting the entropic brain hypothesis 6/n
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Awesome reddit thread of users discussing our latest paper Psychedelics Alter Metaphysical Beliefs, hundreds of replies here. Nice to see how this is a topic of passionate discussion
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The TOP of the principal gradient has been linked to human-specific advancements: cortical expansion, abstract semantics, and longer temporal delays
Neurosynth analysis showed DMT overlapped with language, semantic, and task regions 9/n
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We used EEG to determine the effects of DMT and linked it to various features of experience using real-time intensity ratings and microphenomenological in a neurophenomenological approach rooted in Francisco Varela's research programme
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Earnest and inspired take on what is life and the need to integrate sense-making in biology and consciousness research
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Static RSFC analysis revealed that within-network connectivity was reduced in most canonical networks, while between-network connectivity was prominently increased for high-level networks (DMN, FP, SAL), a finding confirmed by global functional connectivity analysis (GFC) 3/n
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We leveraged DMT’s rapid effects (~10mins) for dynamic analysis using real-time intensity ratings and plasma DMT. We confirmed static results (hyperconnectivity in high-level systems and reduced connectivity between sensory-motor areas). These correlated with 5-HT2AR density 4/n
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Interested in DMT/ayahuascsa-induced sense of familiarity. Check our work lead by the great
@davidwlawrence1
1/2 Pleased to share our new study on the intriguing sense of familiarity occasioned by
#DMT
w/
@neurodelia
&
@AlexPDiBattista
. We found that familiarity is NOT referential to prior psychedelic/DMT experiences & present the SOFQ.
#DMTResearch
#psychedelics
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DMT also flattened the principal connectivity gradient of brain organisation normally (see PCB for a ‘normal state’) separating sensory from high-level areas (or the Transmodal associatiOn Pole; TOP). Higher gradient scores in sensory, lower scores in the TOP 5/n
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Simultaneous EEG-fMRI revealed alpha power and entropy (LZ) significantly correlated with connectivity at the TOP, while delta power involved both sensory and TOP areas. We also found evidence for connectivity in limbic areas related to alpha, gamma, and entropy (LZ) 7/n
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Are you planning to have a 5-MeO-DMT experience? Then please sign up for our survey here (with
@RCarhartHarris
)
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A new survey on self-experimentation with drugs/psychedelics by
@NicolasLanglitz
et al. All cognitive scientists, pharmacologists, and psychedelic researchers invited to respond
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Thank you
@RCarhartHarris
@ProfDavidNutt
@leechbrain
for supervision. Also
@LeorRoseman
Sharad Haridas
@DavidErritzoe
@_fernando_rosas
@lisaxiaolu
@KettnerHannes
@jonny__martell
@ETagliazucchi
Carla Pallavicini
@MGirnNeuron
Andrea Alamia
@Imperial_PRG
for the help 12/n
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Congratulations to
@lisaxiaolu
for leading this amazing work, the rest of the team at the DMT Research Group and everyone at
@Imperial_PRG
, including
@RCarhartHarris
@_fernando_rosas
@DavidErritzoe
. Immense gratitude to Anton Bilton for making our work possible n/n
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4) Poster presentation by
@DavRdl
: Sources and connectivity of EEG activity induced by DMT. Saturday 12:50 - 14:20
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Findings also support the REBUS hypothesis (). While the precision of priors (TOP-related) goes down, increased connectivity in limbic areas may act as the ‘source’ of novel content emerging during psychedelics. More work is needed to test this directly 9/n
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Honored to be a co-author in this brilliant new paper by
@RCarhartHarris
🆓 🚨New view on mental health - Share it!🚨
Link ⬆️ - Free to read for 50 days!
I'll summarise the paper below ⬇️ & please share it❤️
Gist = we get scared & hurt & then stuck. Can't help it. But there's a solution
🧵1/7
#psychedelics
#mentalhealth
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Our findings suggest that by flexibly adapting the intensity and dynamics of DMT, we can probe into neural, physiological and experiential mechanisms of the psychedelic experience, while personalising treatments according to the profile and needs of patients 7/n
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As Oregon legalises psychedelic therapy, the first RCT of psilocybin therapy for major depression has just come out. Congrats
@JHPsychedelics
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Finally, we present (what we call) a coping framework to deal with these issues, which we call psychedelic apprenticeship or psychedelic know-how, based from the enactive, embodied approach inspired in the work of Francisco Varela 2/2
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Really good thread unpacking this major new paper by
@DEOlsonLab
in
@ScienceMagazine
regarding new discoveries on how psychedelics act on the brain at the moleucular level
🧵
#ScienceBreakdown
: "Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors"
Interesting new paper by
@DEOlsonLab
,
@LinTianPhD
, et al. looking at why some serotonin 2A receptor agonists promote neuroplasticity, but others do not.
1/
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Intriguing ERP study suggesting early regulation of emotional reactivity of experienced vs. non-experienced psychedelic users. Some confounds in the sample re meditation and cannabis experience tho
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Cost-effectiveness of psilocybin therapy. Crucial work to understand feasibility of implementation of psychedelics in mental health care
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These findings provide initial evidence of the potential of psychedelics to alter metaphysical beliefs, and have important scientific, societal, political and philosophical implications. 6/6
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Special Issue: The Neural Correlates of Consciousness
looks really good
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New DMT trial at Imperial - Q&A with
@AlexanderBeiner
Thursday, 11 Mar at 6:00 PM GMT on
@joinclubhouse
. Join us!
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Here is the audio for my recent talk at
@ALPSconference
: Can psychedelics provide insights into consciousness?
@paula_deme
@Mimi20220601
@EumelFrau
in the meantime, here is the audio version of
@neurodelia
's
#ALPSconference
talk
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Psilocybin-assisted group therapy for demoralized older long-term AIDS survivor men: An open-label safety and feasibility pilot study
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We assessed different facets of DMTx, which revealed pronounced feelings of immersion into an alternate reality, visual effects, and entity experiences, while ego-dissolution remained low 3/n
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We administered various doses to extend the usually short-lived DMT peak effects (1-2 minutes) to 30 minutes. Elevated intensity ratings collected during the DMTx experience demonstrated success, while low anxiety ratings suggest that the experience was safe 2/n
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4/ We found that the acute scores of 'peak' experiences under DMT correlated with reductions in depression and anxiety scores. Peak experiences were measured via the Oceanic Boundlessness subscale of the Altered States of Consciousness Questionnaire
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Very proud to part of this work led by the multifaceted
@_fernando_rosas
. Check it out for exploring how the heart trips, and how it relates to the tripping brain
Preprint time:
“The entropic heart: Tracking the psychedelic state via heart rate dynamics”
What if we try to track the psychedelic state not from the brain, but from the heart?
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Had a fantastic time at Roveretto at the University of Trento speaking about our DMT research. Super nice over here...
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Future work using neurophenomenological (NP) approaches (rigorous interviewing, experience sampling) will help support or refute how psychedelic experiences/substates relate to the brain effects of our study () 10/n
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Looking forward to hear your feedback. Plus don't forget to check out presentations from other brilliant members of the
@Imperial_PRG
@ProfDavidNutt
@DavidErritzoe
@psybalazs
@RayyanZafar6
@tommaso_barba
@hannahmdouglass
@juliabornemann
@m_wall
@jamesbclose
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3) Poster presentation by
@JWSanders_
: Micro-phenomenology of the intravenous DMT experience (preliminary results). Today 12:50 - 14:20
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Effects of the powerful psychedelic/dissociative Salvinorin A on the human fMRI by
@ManojDoss
@FredBarrettPhD
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Study is preliminary and a first step towards more fine-grained questions. Many thanks to the team for getting this off the ground
@KettnerHannes
@chrisletheby
@RCarhartHarris
@_fernando_rosas
@LeorRoseman
4/4
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We also assessed physiological effects via changes in heart rate. While we found strong elevations at the beginning of the experience, we also found effects normalising while participants were still immersed in the experience, further supporting the safety of DMTx 4/n
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2) Talk by yours truly: Psychedelic apprenticeship in clinical practice, traditional contexts and consciousness science. Saturday 14:40
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Results (N=886) show that the use of psychedelics tend to shift beliefs away from physicalism/materialism, and towards dualism and panpsychism. 3/n
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I will be speaking at New Scientis Live, this September. Come along to get the latest on our DMT research.
#NSLive
See
@neurodelia
discuss exploring consciousness using psychedelics at
#NSLive
this September -
@imperialcollege
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These findings support previous findings of TOP networks being more prominently dysregulated () rather than sensory ones () during psychedelics 8/n
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