Matt Wall (@mattwall.bsky.social)
@m_wall
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Psychologist & fMRI-nerd @Invicro & @ImperialMed . 🧠 + psychedelics, cannabis, sex hormones. Instrument botherer. The secret is to bang the rocks together, guys
London - UK
Joined June 2010
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*Ahem* What I did on my lockdown (part 1). I taught myself the basics of audio production, & recorded a silly song about my favourite imaging modality. I humbly present "The MRI song" in the hope it's a brief distraction from the general hideousness.
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Just got the sweetest, very apologetic email from a student asking me for a copy of a paper because she can't afford the publisher's fee to buy a copy. 😢
NEVER PAY THE PUBLISHERS. Email the authors instead - we LOVE it.
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About once a year I do a two-hour teaching session on fMRI for beginners, for new students. Bit of theory, then a demo of some analysis. Haven't done it this year (obvs) but occurred to me I could do it online and open it out to... well... everyone. Would anyone be interested?
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I just do small-batch, artisanal, hand-crafted, fMRI studies. None of this mass-produced, high-throughput, massive N stuff. Traditional methods, with real organic type I errors, like the fMRI your Grandma used to do.
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Just found out this exists - Playmobil MRI scanner! Though I have questions. Are those tools titanium? Why is the radiographer wearing a watch? Why are they holding what looks like an x-ray? Also, why is the patient smiling - that's not normal either.
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Not wordle. Just my latest set of fMRI results. 🤣
⬛️⬛️⬛️⬛️⬛️⬛���⬛️
⬛️⬛️⬜️⬜️⬜️⬛️⬛️
⬛️⬜️⬜️⬜️🟧⬜️⬛️
⬛️⬛️⬜️⬜️⬜️⬜️⬛️
⬛️⬛️⬛️⬛️⬜️⬛️⬛️
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"Our power analysis showed that we needed exactly the number of subjects that we'd already budgeted for."
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A colleague sent me this - she is seething, and rightly so. I am too. Arrant fucking nonsense, and extremely sexist.
(Need to log-in to LinkedIn to see it unfortunately, but I'll put some 'highlights' below.)
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Finally had to renew my passport and got one of the shit black ones that don't work properly anymore. 😢 Also, they're definitely black, not blue. Stupid brexiters couldn't even get that right.
#BrexitDisaster
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Can I please get some appreciation for this absolutely insane masterpiece of a cake that my missus made for my kid's birthday? Took her literally weeks.
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History in the making - this is the first 'normal' (i.e. not in a clinical trial) script written in the modern era for psychedelic assisted therapy (180mg of MDMA) by Dr Ted Cassidy in Melbourne, Australia. More details here:
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@Drug_Researcher
Sorry this happened to you Matthew. Good rule of thumb - never engage with the UK tabloids, and the Mail is definitely a tabloid.
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The whole indica/sativa distinction that he makes so much of here is absolute bullshit.
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My computer won't boot up properly, think there might be something wrong with it. Anyone got any suggestions?
😱😢🤦♂️
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I have THOUGHTS and OPINIONS on the current psychedelics 'gold rush', and I pitched an article on it to
@ConversationUK
, but they don't seem interested, so I'm just going to do a 🧵 here instead, you lucky people. ⬇️ 1.
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@mistermoviespod
I'm a scientist. I look at people's brains with an MRI scanner, often while they're on drugs. Sometimes I help develop new drugs for things like Alzheimer's disease. I work pretty hard/long hours, but it's a cool job.
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OK - this is happening! Pls RT!
Free, open, online teaching session on "fMRI for beginners"
**Tuesday the 15th of December. 2020, 3-5pm (GMT)**
Sign-up sheet:
Add your name/email; more details on how to join will be sent to this email list. Also see🧵⬇️
About once a year I do a two-hour teaching session on fMRI for beginners, for new students. Bit of theory, then a demo of some analysis. Haven't done it this year (obvs) but occurred to me I could do it online and open it out to... well... everyone. Would anyone be interested?
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🚨🚨New paper day!🚨🚨
"Multiband acquisition sequences for fMRI: Proceed with caution"
VERY proud of this one as it's my first editorial piece. Big thanks to
@layerfMRI
and
@fMRI_today
for asking me to do it. 🧵⬇️
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By some extraordinary set of coincidences I've had three papers accepted this week, as well as a book chapter come out. Pretty sure that's never going to happen again, but it's been a GOOD week.
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@profmusgrave
The CHEESE. The cheese in the US is fucking abysmal. And yes, I know about Wisconsin. It still sucks.
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Is this "doing numbers" now? I'm not sure - never really had one of these before... Anyway, be kind to each other, never vote Tory, and check out my stupid songs if you like:
(The MRI song is the one people seem to like the most, but my fave is A.L. Blues)
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Can I get a hell-yeah for this insanely amazing cake my incredible wife
@Santos_RAB
made for my kid's birthday?
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I've seen a lot of pseudo-science
@neurobollocks
, but this one is an absolute doozy. Added points for wantonly unreconstructed sexism too. A classic.
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Just wrote a new piece on
@Medium
; a very, *very* niche rant about multiband fMRI sequences. May be of interest to one or two of you...
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"Figure 3 shows individual data from a typical subject."
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New principle of brain functional organisation just dropped - brain spirals! 🤔
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Wow - stunningly powerful effect!
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@ME_McCullough
The first rule of journal club is you don't talk about journal club: Defiance of elitist and outmoded conventions in academic discourse.
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Now some top tips. Make sure everyone is using their white AND gray matter during meetings.
I get this a lot, sometimes my gray matter is going like the clappers but my white matter has just popped out for a cheeky cigarette and I can't make anything connect. FFS.
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Finally, ask for impressions AND facts, because "Sometimes it's hard for the female brain to express what they intuitively know." Jesus fucking tap-dancing Christ, what is this, the 1950s?
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If you publish stuff, you need a Google scholar profile, for 3 reasons:
1. You can easily track your papers and citations.
2. Your work is more easily discoverable for others.
3. It lets you obsessively compare yourself with your colleagues and oh God the imposter syndrome...😖
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Earlier this week I made some comments about a recent paper, specifically about the design of the task & the temporal filtering of the fMRI data. Based on some of the feedback I received, I am now convinced that these comments were largely unwarranted, & I wish to apologise. 🧵⬇️
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The last two lines of all my Matlab scripts. You're welcome.
icon=imread('success.jpg');
h=msgbox('Mission accomplished, nerds.','Success','custom',icon);
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A thread on
#microdosing
psychedelics, and why the effects that people report anecdotally are (most likely) placebo effects:
(Edit: This got WAY out of hand. Strap in, space cadets. 1/25.)
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Hey kids! Remember that time I did that online tutorial thing on introductory fMRI analysis and you all came and it was really fun?
Well... we're doing it again!
End of May - Introduction to RESTING-STATE fMRI analysis.
More details soon!
🚨STOP THE PRESSES🚨
fMRI analysis for beginners by
@m_wall
.
This will be a live workshop for those with no previous experience that attempts to be accessible for beginners. Also features a live demonstration of basic analysis in FSL"
Join via:
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Today (Oct 1st) is the 50th Anniversary of the first-ever CT scan! Produced at Atkinson Morley's hospital in South London. Amazing engineering effort, cutting-edge computing, led by Nobel-laureate Geoffrey Hounsfield. Brilliant gallery on the story here:
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Woop woop! New paper day! Read our up-to-the-minute review of psychedelic neuroimaging in Nature Mental Health:
With
@_kategodfrey
@neurodelia
@DavidErritzoe
@RCarhartHarris
@ProfDavidNutt
and others from the
@Imperial_PRG
.
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For anyone who thinks they're magnetic after being vaccinated, I'm very happy to arrange a visit to an MRI scanner. We'll disprove that for you *real* quick.
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Just playing with the latest version of Surf Ice () and there are some seriously shiny/blingy new lighting options. Not sure what I'm going to use these for, but I feel like I need to use them for something!
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Did YOU know that psychedelic therapy with ketamine and holotropic breathwork was happening in 1990s Ireland, 10 yrs before the first paper on the anti-depressant effects of ket was even published? No? Me neither, until the other day. Full story here:
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"There are two kinds of people in this world my friend. Those with grants, and those without."
#scienceamoviequote
http://t.co/ycBHfmRvQL
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"I'm nearly finished with that manuscript draft, you'll have it by the end of the week."
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Thoughts arising from the
#WandaVisionFinale
. I sometimes feel a bit weird about enjoying the MCU content so much. A point
@the_moviebob
makes often is that these were characters & stories created in cheap funny books for children, often to tight deadlines, and they now form (1)
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I have a neuroimaging joke but it needs multiple corrections. 🤨
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Great to see this finally properly published! Biggest phase II trial of
#psilocybin
therapy for treatment-resistant depression so far. Landmark study conducted by
@COMPASSPathway
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I was a reviewer for this paper and its registered report and I honestly thought it was one of the best pieces of work I've ever seen - genuinely landmark research, carefully conducted, and beautifully presented. An absolute triumph. Congrats
@ShuhBillSkee
@OrbenAmy
and others!
New paper alert: "No evidence screen time is negative for children’s cognitive development and well-being: Oxford Study". Find out more and read the paper in full here:
@ShuhBillSkee
@vuorre
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This is my Grandad in 1942 (front tandem, looking back). And this is him on the back of a tandem again nearly EIGHTY years later, in June (my Dad on the front), aged 98. This turned out to be his last ride; he had a huge stroke and passed away in early July.
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@womenpostingws
Hi! Middle-aged British white male here (sorry). I don't get it. What is that thing on her teeth? Does it mean something? Honestly not trying to be a dick about this - people celebrating these accomplishments on here is brilliant -but I want to understand this one!
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Bit of personal news - very honoured to share that as of this month I'm an honorary Senior Lecturer in the Imperial Faculty of Medicine.
@ImperialMed
. Many thanks to
@WaljitD
for the opportunity (and for generally being a great collaborator).
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Today my very first PhD student submitted her thesis. So proud of her and what she's achieved over the last few years. Good feeling.
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2017.
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Roses are red / But can also be blue / If, at great speed, / They come towards you.
#valentinesdayphysics
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If you're ever struggling with imposter syndrome, just remember that the people currently occupying the highest positions in this country are the most aggressively mediocre bunch of fumbling inadequates it's possible to imagine. You're doing fine.
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People of Twitter - I would like to introduce you to Waffle and Pancake. They are squeeeeeee.
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Thread on how to set-up an fMRI study THE RIGHT WAY. First, things you will need:
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I've found concentrating on anything nigh-on impossible today. Had a rough day. Feeling very flat. Not looking for sympathy, but just sharing in case anyone else is feeling the same. It's ok. Tomorrow is another day.
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I don't care what the journal policies are, when submitting manuscripts, put your goddamn figures in the text, not at the end.
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And it's GONE. LinkedIn took it down. Great work everyone!
A colleague sent me this - she is seething, and rightly so. I am too. Arrant fucking nonsense, and extremely sexist.
(Need to log-in to LinkedIn to see it unfortunately, but I'll put some 'highlights' below.)
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Five-year old just said he's tired of making things, doing drawings, and playing in the garden, and "just needs a day off." 🤔😐
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Check out our new paper on the effects of psychedelic therapy on music evoked emotion and striatal connectivity:
(with
@MendelKaelen
@LeorRoseman
@ProfDavidNutt
@RCarhartHarris
and led by
@melissashuk
)
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That's my head on the cover! FAME AT LAST. 😜👍🏻
Today the
@BritishNeuro
is celebrating the arrival of its new journal: Brain and Neuroscience Advances.
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Also ladies, your "anterior cortex" is slightly larger too. "This is the part of the brain that controls emotion and memory." Kill me.
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Here's a fun little story from the early 2000s. In 2002 Ricaurte et al. published findings in the journal Science that MDMA caused severe neurotoxicity in primates, with a dosing regime similar to human recreational use.
Paper:
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Hope they corrected for respiratory & motion artefacts because of every breath he takes, every move he makes...
Sting goes into the scanner: a case study of the musician’s brain (
@thescienceofus
). . Paper:
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They are DIFFERENT children. Take your time, you'll get it. Also the casual horror of this remark is just beyond belief.
How can "3 million UK children be going hungry in the holidays" when there's a national epidemic of child obesity? Eh?
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Where do the Octonauts get their funding? They seem to be extremely well-funded. You never see Shellington or Professor Inkling writing grants. Are the Vegimals Prof. Inkling's PhD students? Is Shellington his post-doc? Am I perhaps over-thinking this?
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We don't bleed people to balance their humors anymore, or perform lobotomies routinely. Why can't psychoanalysis just quietly pass into history too? Seriously, it needs to die.
Women are vulnerable to hysteria because they get confused by having both a vagina and a clitoris This is my best attempt to summarize this incredible abstract
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Calls for unity from the republicans? Fuck that. Time to break out this evergreen tweet again:
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This is going in every single presentation I do from now on until I retire.
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I post this every year, but it's great, so I make no apologies.
Roses are red,
But can also be blue,
If, at great speed,
They come towards you.
#scienceValentines
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You've heard of elf on a shelf, but what about...
(Sorry.)
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Scanning a patient who was terrified of the scanner, but determined to take part in the study. He asked "Is it OK if I cry during the scan?" I stood by the scanner with ear defenders on and held his hand for the whole scan.
#ScienceFeels
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Chris Rorden just released a great new data-viz tool. MRI surface renderer: Surf Ice. Cool.
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46 years old today, and honestly I don't feel a day over 65. 😳
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Hey imaging nerds - new fMRI method just dropped, and it's MAJOR - direct imaging of neural activity, at millisecond time-scales, using MRI.
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Woop woop! New paper out today: "Dissociable effects of cannabis with and without cannabidiol on the human brain’s resting-state functional connectivity"
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The special collection that I've been an editor for at
@SciReports
on "Underlying mechanisms of psychedelics and their use in therapy" is now live! Some great stuff there, and more to come soon!
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What's the opposite of buyer's remorse? Because whatever it is, I have it. 😍
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Just wrote a new piece on
@Medium
, inspired by two recent papers out this week on the search for imaging-based biomarkers in psychiatry:
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Just got the WORST possible outcome for a paper: Rejected, but the reviewers provided really useful, constructive suggestions, which means I now have a significant amount of work to do on the revision, but still have to submit it somewhere else. Damn helpful bastards.
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