Neelanjan Mukherjee
@neelmukherj
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Quantitative RNA Biologist and adrenophile @rnabioco @CUAnschutz he/him
Denver, CO
Joined May 2016
I think this depressed Bills fan speaks for all of Buffalo. I feel for #BillsMafia @theshredline
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Don't miss out on our winter promotion. All 6 rxn riboPOOL kits for 49 โฌ! Request a quote here: https://t.co/gLPsASJBx4 . *Promotion valid until Feb. 28th.๐งก #rRNAremovalkit #RNASeq
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Iโm thrilled to share this story from @Mendell_lab and Jan Erzberger labs, led by postdoc extraordinaire Xiaoqiang Zhu! We showed that in addition to their canonical decoding function, tRNAs play a key role in regulating mRNA stability during translation. https://t.co/gXsJo1Mc1B
science.org
The CCR4-NOT complex is a major regulator of eukaryotic messenger RNA (mRNA) stability. Slow decoding during translation promotes association of CCR4-NOT with ribosomes, accelerating mRNA degradati...
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Happy to see it out and to be part of this fantastic work ๐ฅณ Check out the story on CDS m6A-mediated RNA decay (CMD)!
๐ข Our work on CDS #m6A mediated RNA decay (CMD) is out in @MolecularCell ! Decay relies on ribosome pausing at m6A containing codons. Great collab with the Zarnack lab & colleagues. Check it out here: https://t.co/KSi8SdR91i Thank you @imbmainz @Uni_WUE @ItsRMaP1 ๐ฅณ
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We are up! also a 'featured article' on their homepage https://t.co/LFUNOu8Cj2 CONGRATS to all co-authors! Disrupting the RNA polymerase II transcription cycle through CDK7 inhibition ameliorates inflammatory arthritis | Science Translational Medicine
science.org
CDK7 inhibitors reverse inflammatory macrophage phenotypes and show therapeutic promise in rheumatoid arthritis models and patient synovial cells.
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THE OINC IS HERE! New tour-de-force with @JMTali, years in the making! Direct sequencing of chemical modifications on RNA to measure RNA localization transcriptome-wide. Read about OINC-seq here: https://t.co/4QyBfeejPd
biorxiv.org
Across cell types and organisms, thousands of RNAs display asymmetric subcellular distributions. The study of this process often requires quantifying abundances of specific RNAs at precise subcellu...
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Excited to share our latest work! We developed a new method for studying RNA localization via proximity labeling: OINC-seq! In contrast to other proximity methods, labels deposited on RNAs are read directly by sequencing without a need for biotinylation. https://t.co/SPvrMuw4ld
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Achievement unlocked: 2 papers in the same issue of @CellStemCell, one on the cover with @Pluchinolab and another great one with @pietras_eric lab. Grateful for the opportunity to learn from great colleagues on a daily basis! https://t.co/8QN1Pd8TL2
https://t.co/GdRSb2D07g
cell.com
Ionescu, Nicaise, and colleagues reveal that induced neural stem cells (iNSCs) from patients with progressive multiple sclerosis (PMS) are senescent and exhibit a hypermetabolic phenotype linked to...
๐ Excited to see @BristenaIonescu PhD project, with co-first author @Telencephale, featured on the cover of @CellStemCell - Cholesterol-fuelled neurotoxic senescent PMS iNSCs and its pharmacological rescue is a major leap forward! ๐ (link https://t.co/X5fOiE3jqf)
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The Molecular Biology PhD program is well represented at @SACNAS #2024NDiSTEM! If you are interested in our program, please visit booth 1257 from the Anschutz Campus Graduate School, scan your code for an application fee waiver, and pick up a flyer
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In this Review, La Fleur et al. dive into the world of massively parallel reporter assays (MPRAs) in studying RNA and gene regulation. @YongshengShi @seeliglab Learn more about the power of MPRAs in therapeutic design when coupled with machine learning: โก๏ธ https://t.co/3jG4G5DN7N
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Another opportunity to join the faculty at @VanderbiltU! Deadline is less than 1 week away!
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New lab ๐ฐ in @NAR_Open, the 2nd paper of star postdoc Sveta Farberov. A tour-de-force into how we can use MPRAs to understand binding-function landscape for RBPs. We address the following Qs:
academic.oup.com
Abstract. RNA binding proteins orchestrate the post-transcriptional fate of RNA molecules, but the principles of their action remain poorly understood. Pum
๐Preprint alert! From Sveta Farberov โ ๐๐ฒ๐ฌ๐ญ๐๐ฆ๐๐ญ๐ข๐ ๐๐ง๐๐ฅ๐ฒ๐ฌ๐ข๐ฌ ๐จ๐ ๐ญ๐ก๐ ๐ญ๐๐ซ๐ ๐๐ญ ๐ซ๐๐๐จ๐ ๐ง๐ข๐ญ๐ข๐จ๐ง ๐๐ง๐ ๐ซ๐๐ฉ๐ซ๐๐ฌ๐ฌ๐ข๐จ๐ง ๐๐ฒ ๐ญ๐ก๐ ๐๐ฎ๐ฆ๐ข๐ฅ๐ข๐จ ๐ฉ๐ซ๐จ๐ญ๐๐ข๐ง๐ฌ. A ๐งต for RNA/RBP lovers โ
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Elsevier is one of the largest, most hated and most influential academic publishing companies in the world. How it started & how it's going A thread๐งต
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Congratulations to Denethi Wijegunawardana, a @Yale_INP student & @YaleRNA Steitz Fellow in the lab, for publishing her postbac work from Pallavi Gopal's lab @yalepathology on TDP-43 & Ataxin-2 RNP granules in @Dev_Cell! @YaleNeuro @KavliAtYale @YaleRNA
https://t.co/WHMask8Rar
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Wassup yโall, my first manuscript from the @Aoto_Lab is out! Despite being discovered over 30 years ago, ฮฑ-Nrxn influence on synapses remain enigmatic. Here, we investigate how different mutations in Nrx3ฮฑ affects synaptic properties. Check out this studyโ
jneurosci.org
ฮฑ-Neurexins are essential and highly expressed presynaptic cell-adhesion molecules that are frequently linked to neuropsychiatric and neurodevelopmental disorders. Despite their importance, how the...
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The impact of cell states on heterochromatin dynamics
pubmed.ncbi.nlm.nih.gov
Establishing, maintaining, and removing histone post-translational modifications associated with heterochromatin is critical for shaping genomic structure and function as a cell navigates different...
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๐ฅ๐ฅ๐ฅNew preprint ๐ฅ๐ฅ๐ฅon the EuPRI resource. Where we reconstruct the motifs for 34,736 RBPs and study their function and evolution. Joint work with @ProfTimHughes (Toronto), Matt Weirauch, @LXandR_, Deb Ray, Kaitlin Laverty and many more. More details to come
Reconstructing the sequence specificities of RNA-binding proteins across eukaryotes https://t.co/I1Dh7DR8u7
#biorxiv_genomic
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