Junjie Guo 郭俊傑
@guo_lab
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Assc Prof @YaleNeuro • coDGS @Yale_INP • RNA Neurobiology • Neurodegenerative disease • Immigrant • 🐶 dad • @WhiteheadInst @HopkinsNeuro @PKU1898 alum 🏳️🌈
New Haven, CT
Joined March 2014
Excited to see the work by @Yale_INP students Suzhou Yang @Denethi_W w/ collabs @YaleNeuro iPSC core @jdpereira @ArabTanina and @MayoClinicNeuro @gendron_tania @NeuroUdit on #C9orf72 #ALS & #FTD finally out in @NatureNeuro! @WuTsaiYale @KavliAtYale
nature.com
Nature Neuroscience - By selectively isolating and sequencing the rare RNA transcripts containing C9orf72 repeat expansion from ALS–FTD neurons, the authors uncover an alternative splicing...
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I find it a strange claim that something is understudied because it lacks a proper name 🤷
Many transcriptome regions are translated but not known to encode proteins. They remain poorly annotated and thus under studied, partly due to the lack of terminology for these features. In @naturemethods we propose using "Translon" for any region decoded by the ribosome
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Aberrant splicing exonizes C9orf72 repeat expansion in ALS/FTD @suzhou_yang @guo_lab @Yale_INP @YaleNeuro @YaleMed
https://t.co/8ZGV5YzvSF
nature.com
Nature Neuroscience - By selectively isolating and sequencing the rare RNA transcripts containing C9orf72 repeat expansion from ALS–FTD neurons, the authors uncover an alternative splicing...
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🚨We’re reviewing applications now!🚨 UF Scripps is hiring multiple faculty (Asst/Assoc/Full Prof) in RNA science as part of a major investment.📍Jupiter, FL – a gorgeous place to live + raise a family. Apply 👉 https://t.co/mFL3eyzlI9 Info 👉 https://t.co/ZA0nXRpbuD RT to share!
wertheim.scripps.ufl.edu
Where scientists push the boundaries of human knowledge to solve humanity’s most pressing health challenges. Unique drug discovery tools enable researchers to go further, and seek potential treatme...
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We are hiring a postdoc to work on ribosome quality control and ribosome-mediated stress signaling. Start date is expected to be Fall- Winter 2025. More information can be found here:
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@Yale_INP @Denethi_W @YaleNeuro @jdpereira @ArabTanina @MayoClinicNeuro @gendron_tania @NeuroUdit @NatureNeuro @WuTsaiYale @KavliAtYale @nyscf @McKnightFdn @NIH_NINDS Special thanks to @TargetALS_fdn and @NIH_NINDS for cell lines and @nygenome Center for Genomics of Neurodegenerative Disease (CGND) for the post-mortem RNA-seq data ❤️
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@Yale_INP @Denethi_W @YaleNeuro @jdpereira @ArabTanina @MayoClinicNeuro @gendron_tania @NeuroUdit @NatureNeuro @WuTsaiYale @KavliAtYale Grateful for the support by @NIGMS @nyscf @McKnightFdn @NIH_NINDS. Read it here:
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Congratulations to @Yale_INP student in the lab @Denethi_W and all other 2025 @HHMINEWS Gilliam Fellows! @YaleMed @YaleNeuro @KavliAtYale @WuTsaiYale
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Happy AUG1 RNA Day! We celebrated it by many great discussions at the Gordon conference on #ALS in the beautiful Portland ME. Many thanks to @LuVaDeBo Christine Vande Velde @BarmadaLab Magda Polymenidou for organizing it! @FrattaLab @RueppLab @smslmoon
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📢 Calling all senior postdocs: SYNAPSES brings postdocs from around the world to Yale to share their latest work during an in-person symposium on October 23, 2025. Apply today! Deadline Sept 7. https://t.co/DApsfgEyf0
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Thank you to @PFResearchTeam for this story highlighting the work we've been doing at Yale with @PDClab and Dr. Shawn Ferguson's lab as a Parkinson's Foundation Research Center!
parkinson.org
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While I’m a big fan of new technologies that help us study human biology…there’s still no replacement for animal research! I wrote an article outlining this in @GENbio
https://t.co/CGXeaMs7Fa
genengnews.com
The portrayal of uncaring scientists without any thought for the animals being used in their research is far from the truth.
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Congratulations to Denethi Wijegunawardana @Yale_INP @YaleNeuro for passing her PhD thesis prospectus with valuable inputs from @MattGirgenti @JanghooLim and Steve Strittmatter!
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Excited to welcome Dr. Katie Copley as a new postdoc in our lab @YaleNeuro! She recently completed her PhD in @ShorterLab and did amazing work on designing small RNA chaperones to counteract TDP-43 pathology in ALS-FTD.
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Targeting a lncRNA to treat neurodevelopmental disorders. Congrats @IgorUlitsky!
Stop the doom scrolling! A new 🗞️ from my lab, describing one of our flagship projects of many years we are super excited to share: "Inducible formation of fusion transcripts upregulates haploinsufficient CHD2 gene expression". A 🧵 https://t.co/935AvtPL8S
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In @NatureGenet we report that base editing of trinucleotide repeats (TNRs) reduces somatic repeat expansions in Huntington’s disease (HD) and Friedreich’s ataxia (FRDA)—in patient-derived cells and in vivo—a collaboration with the Mouro Pinto lab. https://t.co/J6MhwEAgoB 1/14
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Celebrating @Yale_INP graduates at the @yaleGSAS commencement 🎉🎉 @MarinaP63 @SChandraLab @LabYogev photo by Anirvan Nandy
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