Mitchell (Min Woo) Kim
@mitchkim_mw
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MD/PhD at WashU | neuroimmune-ing in the @kipnislab | UCLA '16
Joined May 2022
New issue alert👉 https://t.co/uP2kI6DRjj On the cover: Kothari et al. and Mamuladze et al. characterize the role of meningeal mast cells in two distinct pathologies, stroke and meningitis. The image depicts meningeal mast cells surrounding the brain, as stars surround the Earth
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Very excited to share our latest preprint – We find that childhood brain tumours instruct cranial haematopoiesis allowing immunotolerance of childhood brain tumours and CNS development. A thread 1/11 https://t.co/UYAqszigN8
@Gilbertson_Lab @CRUK_CI @LPTrustUK @BrainTumourOrg
biorxiv.org
Recent research has revealed a remarkable role for immunosurveillance in healthy and diseased brains, dispelling the notion that this organ is a passive immune-privileged site[1][1]–[3][2]. Better...
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Excited to share the first paper from my lab in @Nature ! We repurposed the widely used research tool, proximity labeling, to demonstrate its therapeutic potential in antigen amplification for immunotherapy using mouse tumor models and patient samples. https://t.co/LISBT6GzXB
nature.com
Nature - Red light- or ultrasound-controlled proximity labelling is engineered to stimulate clustering-induced receptor activation and downstream signalling amplification to promote antitumour...
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Excited to share our new preprint🚨Single-cell mapping across neuroinflammation reveals that meningeal monocyte-derived LAMs drive progression, while microglia are protective! New insights for progressive MS🧠 https://t.co/vjMe3iMT50 Thank you @SarahMundt5 @FlorianIngelfi1 &collab
biorxiv.org
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) characterized by increasing disability. The cellular and molecular drivers of clinical transition towards...
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🧵1/ Excited to share my first publication from the @ColonnaLab in @NatImmunol! We investigated how mutations in the human CSF1R gene disrupt microglia and impair white matter integrity in a rare but devastating neurodegeneration called ALSP. https://t.co/39kxODSumy
nature.com
Nature Immunology - Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia is a neurodegenerative disorder caused by pathogenic CSF1R mutations. Here the authors find that...
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Our new study by @DuSiling reveals how CSF1R mutations in adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) disrupt glial homeostasis. Key roles for oligodendrocytes, astrocytes & STAT3 signaling. https://t.co/k2PsmXO9mX
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How are big proteins washed out from CSF, if they can’t go through the glymphatic system? Here is how: our new finding on glymphatic bypass || https://t.co/A9C5DsexiU Congrats @Drieu_Antoine and Ben Plog and thank you to our many collaborators!
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Excited to share our second CSF research breakthrough with Dr. Hokyung Jin, Dr. Seon Pyo Hong, and Prof. Gou Young Koh (@gou_koh) - now published in Nature! Link below. (1/10) https://t.co/xAnzgjX8rw
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Congrats to the authors @Yale on this exciting and important work! #BrainTCellsRule || The subfornical organ is a nucleus for gut-derived T cells that regulate behaviour | Nature
nature.com
Nature - A distinct population of CD4 T cells resides in specific regions of the steady-state brain, and these T cells are programmed in the periphery by the microbiome to coordinate adaptive...
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Specialised highways at the CNS borders have reshaped how we think about brain clearance, immunity, and disease. Check out our latest review discussing this led by Da Mesquita Lab and with @NedergaardLab
thelancet.com
The existence of specialised structures that allow a continuous exchange of CSF between different anatomical compartments at the brain–meningeal border is challenging conventional notions around...
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Murphy Lab Bay #2: proving that science and chaotic shenanigans can coexist. 🙌 @SunnyKimNov2016
Scientists have found that C/EBP⍺ activates an IRF8 #enhancer, driving its expression in early myeloid progenitors and specifying type I conventional #DendriticCell lineage. @washu_pathology @JingNeticist Read more in Science #Immunology: https://t.co/stvtqL9ZPb
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ECM remodeling occurs in the meninges during aging and following CNS trauma. In our latest work, led by @KateHitpass and @t_stevenson95, we show how this ECM remodeling contributes to the meningeal lymphatic drainage deficits seen in these conditions.
jneuroinflammation.biomedcentral.com
Efficient clearance of central nervous system (CNS) waste proteins and appropriate immune surveillance is essential for brain health. These processes are facilitated by lymphatic networks present in...
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and how dysfunctional meningeal lymphatics regulate synaptic physiology in a microglia-dependent manner https://t.co/AZ4eOJXd4c
cell.com
Dysfunctional meningeal lymphatics interfere with the inhibitory synaptic inputs and disrupt excitatory/inhibitory balance on cortical neurons in a microglia-IL-6-dependent manner. Enhancing the...
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The new issue is out! 👉 https://t.co/7FRErzTs9T On the cover, Beckwith and Brunner et al. uncover that chromosomes self-organize into their characteristic mitotic rod shape through the formation of large and extensively overlapping DNA loops 📷credit: Andreas Brunner.
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What a beautiful cover of @ImmunityCP ! Thank you @Ella_Maru and team and bravo @mitchkim_mw for the idea! ❤️👍🤩
The brain & immune system are more connected than ever imagined. In this issue of @ImmunityCP, 9 articles explore major advances & future directions in neuroimmunology. Take a look! https://t.co/zjKsAmiumU
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The brain & immune system are more connected than ever imagined. In this issue of @ImmunityCP, 9 articles explore major advances & future directions in neuroimmunology. Take a look! https://t.co/zjKsAmiumU
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Excited to share our new work demonstrating a role for astrocytic inflammasome signaling in modulating hippocampal plasticity. All credit to @kzengeler, who was the brains🧠 and muscle💪 behind this project and is a wonderful collaborator.
Happy to share our work on hippocampal inflammasome signaling. Thank you to members of the lab for critical experimental support, @BIG_Center_UVA colleagues for input, and @LukensJohnR for baller mentorship - it's been an honor working with you all!
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Happy to share our work on hippocampal inflammasome signaling. Thank you to members of the lab for critical experimental support, @BIG_Center_UVA colleagues for input, and @LukensJohnR for baller mentorship - it's been an honor working with you all!
cell.com
The function of immune pathways in homeostatic neurobiology remains underexplored. Zengeler et al. find that the inflammasome complex, typically associated with immune responses, is involved in...
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The gylmphatics of our brain, which clear waste products, interact with our immune system and are key to preserving brain health, modulating its aging process, and propensity for neurodegenerative diseases A superb review @jonykipnis @ImmunityCP
https://t.co/2YNFUmDQ2N
cell.com
Recent discoveries of glymphatics and meningeal lymphatics have redefined our understanding of CNS immunosurveillance. Kim and Kipnis illustrate how the clearance of brain-derived antigens creates an...
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Excited to share the review by @mitchkim_mw on how brain washing is linked to Neuroimmunology || Glymphatics and meningeal lymphatics unlock the brain-immune code: Immunity
cell.com
Recent discoveries of glymphatics and meningeal lymphatics have redefined our understanding of CNS immunosurveillance. Kim and Kipnis illustrate how the clearance of brain-derived antigens creates an...
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