RT @ItaiYanai: According to one experienced editor, authors are 99% of the time wrong when stating they are 100% sure they know the identit….

RT @storzlab: Excited that Aoshu Zhong's exciting work on an antitoxin encoded within a toxin is now published. Lovely to collaborate with….

So excited for you to join us @MITBiology. And especially excited for your lab to be down the hall from mine. Welcome, @sokrypton!.

RT @BiotechMongoose: I wonder what it's like to have a very specific hole in one's thought processes that results in "surely this uni admin….

RT @edyong209: 👋I’m back. And I wrote about the current wave of attempts to downplay long COVID—less outright denial & more "it’s real but….

RT @TypasLab: Last chance to submit an abstract for this year‘s „New approaches and concepts in Microbiology“ meeting.

RT @AnnaPodgornaia: @Lis_Lowe @Addgene Yes! Histidine in histidine kinase, forever. @michael_laub8.

Thanks @MarraffiniLab for hosting me at Rockefeller last Friday! An amazing visit - great science and great people from start to finish.

RT @PeterFineran: Such a pleasure for @L_M_Smith and I to highlight for @MolecularCell the amazing work in @Nature from @tongzhang1109 @gem….

RT @chngin_the_wrld: Really jazzed to share a #review on #phagetherapy @CellCellPress that I wrote w/ @Vivek_Mutalik @GHatfull & @chipatucs….

Yes!! Love seeing @tongzhang1109 highlighted in this shoutout to #womeninSTEM - richly deserved!.

Cannot emphasize enough the work and brilliance of @tongzhang1109 throughout this project. And a simply spectacular set of collaborators, @gem__atkinson, @hauryliuk, Abel Garcia-Pino, and their labs! 6/6.

Some cool parallels to the sensing of molecular/pathogen associated molecular patterns by eukaryotic innate immune proteins. Also, our work suggests that TA systems aren't necessarily activated by proteolysis. Indeed, CapRel (and others. ) can respond to phage proteins! 5/6.

With Gemma, Vasili, and Abel, we found that the capsid directly binds the CapRel protein to promote an open, active state that then blocks translation to prevent phage replication. 4/6.

Howver, like so many of the other new anti-phage defense systems being discovered of late, it was unclear how this TA system got activated in response to phage infection. Through some clever genetics, @tongzhang1109 discovered that the phage's capsid protein was key. 3/6.

They had identified CapRel TA systems and shown they could sometimes pyrophosphorylate tRNAs, but to what end was unclear. Meanwhile, we'd gone all in on the idea that TA systems play major roles in anti-phage defense. And indeed, some of the CapRels turn out to do just that! 2/6.

Happy to see the final version of this paper out in @Nature. Led by the incredible @tongzhang1109 and fantastic collaborators @gem__atkinson @hauryliuk and Abel Garcia-Pino. Started after serving as outside examiner for a student of Gem and Vasili's. 1/6.

RT @npariente: Caulobacter produces a phage-like element that provides template DNA recombination, enabling survival in genotoxic condition….

I loved working on Caulobacter, but my lab's interests have evolved and we're onto new problems/ideas. Will still follow Caulobacter and esp work from fantastic former trainees: Kevin Gozzi @monicasguo @GuzzoMathilde @Tung_BK_Le @krijonas @dnarepairlab @EBiondix 2/2.

Very happy to see this work led by Kevin Gozzi published in @PLOSBiology! GTAs are weird, amazing entities. Also represents end of an era for me- last Caulobacter paper from my lab after working on this bug since I was in grad school. 1/2.