Natalie Porat-Shliom
@PoratShliomLab
Followers
961
Following
2K
Media
56
Statuses
720
Cell Biologist and microscopist. My lab @theNCI focuses on mitochondria, metabolism and liver cancer. Views are my own #cellbiology #microscopy
Bethesda, MD
Joined November 2012
Preprint alert!! How zonated hepatocytes adapt to changes in lipid influx due to fasting or a Western diet (WD). We developed a microscopy-based phenotyping method called single-cell phenomics (scPhenomics) to measure the features of mitochondria and lipid droplets (LDs).
Spatially resolved rewiring of mitochondria-lipid droplet interactions in hepatic lipid homeostasis. https://t.co/MoYrKgfPt5
#biorxiv_cellbio
8
36
120
I am honored to be named a 2025 ASCB Fellow! It is a privilege to be part of the ASCB community. ASCB was the first conference I attended as a grad student, and it has always been a welcoming, supportive home. Thank you for this kind recognition! ☺️ https://t.co/sfnhbvTuJB
ascb.org
The American Society for Cell Biology (ASCB) is proud to announce the election of 14 outstanding scientists as 2025 ASCB Fellows—a prestigious honor recognizing their exceptional contributions to...
30
11
134
I’m extremely honored to be recognized with the WICB Junior Research Award. @ASCBiology and WICB have been key to my career development since I attended my first annual meeting in 2005. Congrats to the other awardees!
Meet the 2025 ASCB Award Winners—trailblazing scientists honored for research, mentoring, education, and innovation. Celebrate excellence across all career stages in cell biology. Read more: https://t.co/d8fjwc4OIA
28
13
133
Lipid metabolism and neuroinflammation: What is the link? https://t.co/8mWkpx5Pxe Another nice review covering lipid metabolism in the CNS, including discussion of interferon pathways and their connection to lipid regulation
0
5
20
Thank you Matthias @labs_mann for your visionary leadership and for creating a scientific family that continues to push boundaries. Congratulations from all members and looking forward to the future! #MS #Proteomics #20Years
🎉Congratulations to Matthias Mann on 20 years leading Proteomics & Signal Transduction at MPI of Biochemistry! Two decades of groundbreaking mass spectrometry research and training excellent future scientists. #MS #Proteomics #Science @labs_mann
1
7
79
ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox | Science
science.org
Maintenance of mitochondrial redox homeostasis is of fundamental importance to cellular health. Mitochondria harbor a host of intrinsic antioxidant defenses, but the contribution of extrinsic,...
0
13
35
It has been a dream come true to lead a rotation in the transformative @MBLScience Physiology course these past 2 weeks…
1
3
84
Super-resolution microscopy of mitochondrial mRNAs | Nature Communications https://t.co/qMdA2pwwUM
nature.com
Nature Communications - Stoldt, Maass, and colleagues present a study where smFISH is combined with STED and MINFLUX microscopy to map mitochondrial mRNA at nanometre resolution, enabling the...
1
4
22
Two papers, three dimensions! Anna Maria Reuss describes a generic technique for 3D-histology of human archival paraffin blocks, and Francesca Catto shows breathtaking videos of mouse brains with Alzheimer's. https://t.co/CC7KxtIF3Y
https://t.co/qL7nnTFC2G
1
15
92
Our new preprint on metabolic adaptation of the nucleus vacuole junction NVJ is online! Big thank you to @MarieHugenroth and all authors! #MembraneContactSite
https://t.co/Dvm90Hj6xY
biorxiv.org
The nucleus vacuole junction NVJ in yeast is a multifunctional contact site between the nuclear ER membrane and the vacuole with diverse roles in lipid metabolism, transfer and storage. Adaptation of...
5
6
34
Very excited to share our latest work, “Mitochondrial presequences harbor variable strengths to maintain organellar function,” led by the fantastically talented @WashUBBSB graduate student Youmian Yan. A 🧵 https://t.co/UbrKcjoESv
biorxiv.org
Hundreds of mitochondrial-destined proteins rely on N-terminal presequences for organellar targeting and import. While generally described as positively charged amphipathic helices, presequences lack...
4
16
48
Thrilled this paper is out! We solved the first cocrystal structure of FSP1 with an inhibitor (FSEN1), providing mechanistic insight & a foundation for medchem. Led by @AMegarioti & Sitao Zhang. A terrific collaboration with Da Jia. Brief Tweetorial! 1/9 https://t.co/9U7DSHJwIO
pnas.org
FSP1 is an FAD-dependent oxidoreductase that uses NAD(P)H to regenerate the reduced forms of lipophilic quinone antioxidants, such as coenzyme Q10 ...
13
20
96
Excited to present first publication from the Joshi lab, now in @JCellBiol. Here, we show that phosphatidic acid regulates Pex30 distribution at ER subdomains for lipid droplet biogenesis by binding to dysferlin domain.
9
12
56
One of my favorite podcasts!
0
0
6
The abstract submission deadline for the 2nd edition of our #EMBOLipidDroplets Workshop (21-26 September 2025) is approaching. Check out the agenda with an amazing lineup of speakers and submit your abstract before 10 June 2025! @EMBO
@Co_Biologists
https://t.co/ytoQzXt3Oj
0
15
50
Milestones is an annual publication covering the exciting research performed @theNCI @IRPatNIH. This year, my group's study on hepatic mitochondria was beautifully covered alongside clinical, translational, and basic research. Honored to be included! https://t.co/cfryxpylO0
ccr.cancer.gov
Every year, CCR makes remarkable contributions to the understanding, detection, treatment and prevention of cancer. This digital-only issue of our annual publication, Milestones, features 13 of our...
1
0
8
Jason Casler @JasonCasler1, Clare Harper and Laura Lackner find that mitochondria–plasma membrane contact sites regulate the ER–mitochondria encounter structure. https://t.co/Z7g4zSKvDf
#JCSMitoSI #OpenAccess #ReadandPublish
1
8
16
Proud present our latest work led by @_blessypaul, now in Developmental Cell @Dev_Cell. Here, we characterize an ER-localized antioxidant enzyme in humans and Drosophila that acts as a lipid quality control factor to suppress ER lipid oxidation. https://t.co/XBj1WphJqP
0
10
50
Reminder: The 1st FASEB #Ferroptosis Meeting is this summer! Spectacular speaker lineup + short talks selected from submitted abstracts. It is going to be awesome! Trainees, newcomers & all interested are welcome! 📅 Abstract deadline: June 1, 2025. https://t.co/XF2CZdNJND
1
13
51
MBoC (@ASCBiology Society Journal) is looking for Early-Career Editorial Board Members! https://t.co/e2YdqzZKdW Submit your application by May 22, 2025!
ascb.org
Are you a senior postdoc or early-career faculty member who’s passionate about publishing, peer review, and amplifying great science? We’d love for you to consider joining the Molecular Biology of...
0
4
7
A mentor, colleague and friend, Theo is an excellent physician-scientist working to establish knowledge and develop new cures for chronic liver diseases. This is what we do at @NIH
@NIDDKgov
Dr. Theo Heller, renowned NIDDK scientist, physician and educator, gave the Distinguished Clinical Research Scholar and Educator in Residence Lecture at NIH Grand Rounds, highlighting the gut-liver connection in chronic liver disease. https://t.co/54q13lNl1U
3
5
28