Division of Molecular and Cellular Function UoM
@MCF_UoM
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Molecular and Cellular Function Division at the Faculty of Biology, Medicine and Health, University of Manchester @FBMH_UoM @OfficialUoM
Manchester, UK
Joined December 2020
In our study @eLife we uncover the mechanism of mPPase inhibition. Many structures to date are in a symmetric form. We use EPR(PELDOR/DEER) and reveal asymmetric binding at the active site while maintaining a symmetric conformation at the periplasmic site https://t.co/vQXx581ZJZ
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Exciting times at the SBS (@OfficialUoM)! Our ELEXSYS E580Q Spectrometer has found its new home. Watch as an empty lab is turned into a cutting-edge #EPR lab — and hear from Prof. Pliotas, who leads the research group driving innovation. Watch the video:
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This is a reminder that you can find us on Bsky now, just search for "mcf-uom". You can find all the updates there!
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Paper alert! @PliotasGroup reviewed pulsed dipolar electron paramagnetic resonance spectroscopy applications and highlighted emerging strategies for future studies https://t.co/6fOHgongEY
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Very glad to see this study finally out - it's been a huge #collaboration across many different aspects around the topic 🙏🏻 Fibroblasts recycles (in a #circadian manner) collagen to make new fibrils, which is enhanced in #fibrosis
@MCF_UoM @wtccmr
https://t.co/S4xnj6BNLy
@eLife
elifesciences.org
Secretion and fibrillogenesis of collagen-I are separately controlled molecular pathways in the fibroblast, where surprisingly endocytic recycling is required for fibril formation and is increased in...
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Paper alert! A collaborative study led by @tranejoan published in @eLife shows that circadian-regulated endocytic recycling is central to homeostatic assembly of collagen fibrils and is disrupted in diseases.
elifesciences.org
Secretion and fibrillogenesis of collagen-I are separately controlled molecular pathways in the fibroblast, where surprisingly endocytic recycling is required for fibril formation and is increased in...
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We reviewed recent pulsed #EPR Spectroscopy (PELDOR/DEER/PDS) applications on integral membrane proteins, enabled through Spin Labelling. Great to see the field moving forward! @DrAnokhiShah Josh Wort @mayue3691 @MCF_UoM @FBMH_UoM @UoMMIB
https://t.co/HdVCxlesrH
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Bicentenary PhD scholarship is available in @XimenaSoto40 group. If you are enthusiastic and keen on using Zebrafish to elucidate signals and mechanisms involved in spinal cord regeneration apply! The deadline is the 10th of January, 2025. https://t.co/WKuiVBmTdq
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You can find us on Bsky now, just search for "mcf-uom". See you all there!
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BioEmPiRe led by @PliotasGroup has acquired new cutting-edge equipment to address fundamental biological questions!
The wait is finally over! The new @bruker high power (300W), with AWG, pulse Qband #EPR spectrometer with integrated He-free system from Cryogenics has been installed and is ready to use for @BBSRC-funded BioEmPiRe initiative https://t.co/ffe4BQOJGn
@MCF_UoM @UoMMIB @FBMH_UoM
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If you’re interested in cancer early detection research training, @TheByronLab has a non-clinical PhD opportunity with the International Alliance for Cancer Early Detection (ACED): https://t.co/0m9Xp3BJHa
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Excellent PhD opportunity under @tranejoan supervision aiming to interrogate the molecular mechanisms of how different types of macrophages exert their influence on fibroblast biology. Apply here: https://t.co/na15xGuqzQ
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Tackle real world challenges in health and science, make a difference and discover your future at @OfficialUoM . Join us for our Postgraduate Research Open Day on Wednesday 13th November, 1-5pm. Register now: https://t.co/3lG4L4TAis
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Interested in doing a PhD in cancer cell biology? @TheByronLab have a fully funded @The_MRC PhD studentship opportunity. 🔗 For details on the project, and how to apply, click here: https://t.co/ykO9oywfWn
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Are you a clinician looking to undertake a PhD in cancer cell biology research? @TheByronLab have a Clinical Research Training Fellowship opportunity with @MCRCnews. Details here: https://t.co/97d9va1g9C
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MRC-funded PhD is available in my group. If you are enthusiastic and keen on using Zebrafish to elucidate signals and mechanisms involved in spinal cord regeneration apply! Deadline 15th November more information below @MCF_UoM @FBMH_UoM @FBMH_DocAcad
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Kerrie Marie, Rebecca Lee and Adam Hurlstone are recruiting PhD candidates for a project that focuses on preclinical, translatable science and mechanistic studies and has strong ties to the clinic. Please follow the link below if you want to learn more. https://t.co/nplg5hMSIT
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We have two exciting funded PhD opportunities to join my young and vibrant team @Nagarajan_Lab : 1. Bioinformatics PhD on single cell transcriptiomics, genomics, epigenomics and machine learning https://t.co/HqQ53fGYtd 2. PhD on Molecular biology of cancer dormancy in breast
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Dr @grzechnik_pawel will collaborate with the RNAHub (Roche Pharma Research and Early Development) as part of the Roche Access to Distinguished Scientists Programme. We are joining forces to investigate the impact of antisense oligonucleotides on RNA synthesis in human cells!
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Non covalent spin labelling enables EPR distance measurements for dynamics on the human tetrameric TRPC5 ion channel. With 84 x native Cysteines, TRPC5 is not accessible by conventional spin labelling methods. CryoEM structures with spin labelled substrates confirm DEER findings
Very happy to share our latest preprint: Non-covalent spin labelling of TRPC5 ion channels enables EPR studies of protein-ligand interactions | ChemRxiv - https://t.co/MY9Cp3Qqfx
@UoL_LICAMM @AstburyCentre @chemleedsuni @OfficialUoM @univofstandrews @unibirmingham
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