Jo Edward Lewis
@joedwardlewis
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Assistant Research Professor investigating the gut-brain axis (with a special interested in GIP) at the Institute of Metabolic Science @MRL_Cam. Views, own, etc
Joined July 2009
Really proud of this special issue convened by @Peter_Aldiss and I, with the support of @ThePhySoc, on the physiology of obesity. Stay tuned for part 2.
The latest issue of @JPhysiol is out now and includes the first half of our special issue 'The physiology of obesity: from mechanisms to medicine' Read it now ๐ https://t.co/5giG77peV0
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I am excited to share our latest paper @Nature where we construct a hi-res spatial map of the human hypothalamus, the brain region central in appetite control. It is a collaboration between @IMS_MRL @Cambridge_Uni & @MPI_Metabolism
https://t.co/04ZLrCDJ2N
nature.com
Nature - HYPOMAP integrates single-nucleus RNA sequencing and spatial transcriptomic data to create a comprehensive spatio-cellular map of the human hypothalamus.
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CAN'T WAIT for our (@cld536) @ThePhySoc meeting in July. Speakers inc. @Hodson_Group @joedwardlewis @lab_cota @TonyGoldstone @Roberts_Lab @BarteltLab @blaak_e @echouchani & more. We also have 15x ECR talks + posters so make sure you register and submit! https://t.co/g3zPuBXYIO
physoc.org
The Physiology of Obesity: From Mechanisms to Medicine 2025 is the first in-person Physiology M2M conference which will explore diverse topics in the field of obesity.
SAVE THE DATE The 1st in-person Physiology of Obesity M2M with @ThePhySoc 8-9th July '25 @UniofNottingham Exciting speakers inc. @joedwardlewis @TonyGoldstone @Roberts_Lab @BarteltLab @echouchani @fionamcgill_UCD confirmed & will be 15x ECR slots! https://t.co/XYyqvNYIH3
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SAVE THE DATE The 1st in-person Physiology of Obesity M2M with @ThePhySoc 8-9th July '25 @UniofNottingham Exciting speakers inc. @joedwardlewis @TonyGoldstone @Roberts_Lab @BarteltLab @echouchani @fionamcgill_UCD confirmed & will be 15x ECR slots! https://t.co/XYyqvNYIH3
physoc.org
The Physiology of Obesity: From Mechanisms to Medicine 2025 is the first in-person Physiology M2M conference which will explore diverse topics in the field of obesity.
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Our latest on understanding GIP agonism v antagonism. Shout out to @TimoMueller_IDO since lots of this work replicated work from his group. We tried to take it a little farther. Genetic loss of GIP signaling in CNS increases weight loss to GLP-1 agonists. ๐ช
Does loss of GIPR signaling sensitize GLP-1R+ neurons, enhancing the actions of GLP-1R agonists? New data from @seeleyrj @UMich @MolMetab @UMDiabetes
https://t.co/WfKpDEXwbm
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Absolutely delighted to have my latest paper out in @AGA_Gastro with @MetteK_And and @damato_mauro
https://t.co/Ksz0H3jAFZ And absolutely wild to have it picked up by the @Independent
https://t.co/IVjNIAHzvz And by the @newyorkpost
https://t.co/z6DA5kX32V
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Good news! Our revue "Physiology of physical inactivity, sedentary behaviours and non-exercise activity: insights from the space bedrest model" received enough citations to be a #TopCitedArticle in @JPhysiol โบ๏ธ @A_Bergouignan @natedejong115
https://t.co/Wp2tNTRgET
physoc.onlinelibrary.wiley.com
Abstract figure legend Although the exact physiological mechanisms remain unclear, sedentariness has been shown to negatively affect metabolic health and the main organs involved in its regulation....
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Drugs like Ozempic are great for weight loss, but they make some people feel sick. We discovered that the brain circuits mediating the appetite suppression are distinct from those that mediate nausea โ a finding that may be leveraged to develop more selective GLP1-based drugs.
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๐๐๐ญ๐๐๐จ๐ฅ๐ข๐ฌ๐ฆ ๐ข๐ง ๐๐๐ญ๐ข๐จ๐ง โ ๐๐ช๐ฎ๐ฆ ๐ ๐๐ฑ๐ข๐ค๐ฆย ๐ฉโโ๏ธ ๐๐ณ๐ฆ๐ข๐ต๐ฎ๐ฆ๐ฏ๐ต We are excited to announce that the application period is now open for Metabolism in Action 2024! The @ScienceCluster conference on November 18-22 will bring together leading experts with the
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Often people will say, X food or activity increases GLP1, but in this Huberman Lab episode out now @zaknight explains why enormous increases in GLP1 are necessary for weight loss; increases that pharmacology alone can produce. Itโs also a master class in the control of hunger.
New Huberman Lab podcast out now: THE SCIENCE OF HUNGER & DRUGS TO COMBAT OBESITY w/ @zaknight @HHMINEWS โขNeural Control of Hunger โขDopamine & Food โขGLP1 Drugs & the Next Versions Coming โขProcessed Foods & the Brain โขThe Thirst & Hunger Link https://t.co/WCVMPYrhv8
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Congrats to @joedwardlewis on the fascinating model and findings in which DREADD-activated endogenous GIP secretion reduces food intake and body weight in DIO mice. https://t.co/DBVA1ZF2Pu
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Targeting gut endocrine cells is a logical yet challenging therapeutic target with small molecule GLP1RAs looming. Here the team @CamMetaboNet uses chemogentics to link K cells to reduction of food intake @MolMetab
https://t.co/6kJDIVoniT
#weightloss
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Very happy to see this research finally out. https://t.co/hN2WjnElc9 Hats off to @LoraHeisler @GilesYeo @gkcdowsett and Xless Antonio Gonzalez, Sergiy Sylantyev and Yuliia Martynova for their support.
cell.com
Martinez de Morentin etย al. identify GABAergic neurons in the dorsal vagal complex as a new player in the circuit governing feeding behavior and body weight.
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Check out our latest research - A brainstem to hypothalamic arcuate nucleus GABAergic circuit drives feeding: Current Biology
cell.com
Martinez de Morentin etย al. identify GABAergic neurons in the dorsal vagal complex as a new player in the circuit governing feeding behavior and body weight.
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New pre-print out on the development and characterisation of a novel #FGF21 KO rat for #MASH and alcohol intake. Delighted to share some work from my @DDEA_Denmark fellowship with @MatthewGillum6 @Metabolcenter and a wonderful collab with Gubra. https://t.co/Uvi1krpO4h
biorxiv.org
Objective Fibroblast growth factor 21 (FGF21) is a hepatokine that improves dyslipidemia, steatosis, inflammation, and fibrosis. FGF21 analogues are in clinical development as treatments for metabo...
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PLEASE RT/SHARE Finally recruiting a Postdoc RA/Fellow to the group to do some human work on FGF21 and alcohol intake/preference. Neuroimaging experience preferred but please get in touch if interested! https://t.co/4jYErQHXPQ
jobs.nottingham.ac.uk
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Only 10 days to the registration and abstract deadline - don't delay - sign up today ๐๐๐๐๐ 5th Incretin Study Group Meeting 4-6 April 2024, Cambridge https://t.co/eOqL1N4Ytm
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Nausea and vomiting in pregnancy linked to hormone from fetus https://t.co/TI7psoCsAr Thanks to Alice and Rachel for this very nice News and Views !
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BSN ANNUAL MEETING - Save the date! 1-3 July 2024 Get ready to join us at #Aberdeen2024 โ our annual meeting will highlight the latest neuroendocrinology research with a strong focus on our early-career researchers. More info: https://t.co/qOuzJf6tcy
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1/ So, @UniofNottingham are recruiting this years intake of 'Nottingham Fellows'. You get the chance to start your own independent group, with 3y research time on 'Tenure Track' leading to a permanent R&T post as Asst Prof. PLEASE RT https://t.co/6vdN2aiEuj
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Weโre thrilled to share our preprint (collab with @marionilab) in which we use human POMC neurons to identify potential anti-obesity drugs, one of which seems to increase the efficacy of Semaglutide (Ozempic). Details on BioRxiv: https://t.co/lkdYYhFDq7. Thread below ๐งต(1/16)
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