Amgen's new GLP-1R agonist/GIPR antagonist, AMG 133, is making waves in the anti-obesity field. Curious? . Our latest short piece highlights the first clinical success of AMG 133, its background, and the GIPR-centric questions that arise from its success.

RT @Josh_Ward: You can’t beat The Sandlot’s 4th of July scene. Happy 4th, everyone! 🇺🇸

RT @barstoolsports: THE GREATEST TO EVER DO IT. 17 NATHAN’S HOT DOG TITLES FOR JOEY CHESTNUT

RT @barstoolsports: Joey Chestnut’s walk out. Goosebumps.

RT @Cell_Metabolism: Semaglutide effects on energy balance are mediated by Adcyap1+ neurons in the dorsal vagal complex .

The champ is back!!! 👑.

RT @DanielJDrucker: Studies in mice reveal that LEAP2 analogs have the potential to enhance the efficacy of glucagon-like peptide 1 recepto….

RT @DanielJDrucker: Innovation in the #weightloss space continues with an emerging Triple G oral peptide #obesity to enter into clinical de….

RT @NatMetabolism: Triglycerides are an important fuel reserve for synapse function in the brain

RT @NeuroscienceNew: Clearing Brain Sugar Stores Could Protect Against Dementia. New research has revealed that glycogen metabolism in neur….

RT @doctorveera: A new preprint dives into the ever-fascinating noncoding universe, offering fresh insights that reshape our understanding….

RT @CarlssonLab: Biased adrenergic agonists – a novel treatment for diabetes! Amazing paper in Cell from a project led by @ProfBengtsson (S….

RT @DanielJDrucker: More preclinical data extending the anti-aversive actions of GIP through studies of Tirzepatide .

RT @DanielJDrucker: @Diabetes_ADA @AmDiabetesAssn Finally Jon Campbell @DukeMedSchool synthesizes gain and loss of GIPR science, reconcilin….

RT @zenbrainest: Synergistic behavioral and neuroplastic effects of psilocybin-NMDAR modulator administration.#psychedelics .

RT @FierceBiotech: The FDA is introducing a new priority voucher program designed to shorten the drug review process from 10 to 12 months d….

RT @eLife: One protein, two opposing roles: This ‘compelling’ study shows how the same signalling molecule can drive either protrusion or r….

A wild observation - Indiana is on a generational run. Eli Lilly. Pacers. IU football.

Excited to share our commentary on how Tirzepatide modulates metabolic adaptation and shapes the energetic states behind GLP-1/GIP-induced weight loss. If you’ve wondered why losing weight with GLP-1s looks a bit different from when you've tried dieting alone. take a look!.

RT @DanielJDrucker: Can one meaningfully predict satiation responses and treatment outcomes with GLP-1 medicines such as liraglutide? .http….

RT @arshukla: Molecular Design of Unimolecular Tetra-Receptor Agonists | Journal of the American Chemical Society