Irma Querques
@irma_querques
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Structural bio(techno)logist | #NewPI at @MaxPerutzLabs | Mobile DNA lover & CRISPR newbie
Joined October 2017
📢 I have two open @ERC_Research fully funded #postdoc and #PhD positions in my lab at @MaxPerutzLabs on the @viennabiocenter campus. We are looking for structural bio(techno)logists with a passion for nucleic acid binding proteins and genome editing. Deadline for PhD: Oct 15th
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Wooow
New work from @stephentang23 et al. that describes a fascinating set of reverse transcriptases involved in antiviral immunity. They synthesize tandem-repeat cDNAs that resemble telomeres, revealing an unexpected bacterial evolutionary origin of telomerase. Check out the thread!
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EMBL’s 2025 Kendrew alumni award recipient may know how to make fairy tales come true. Irma Querques repurposed the ‘Sleeping Beauty’ transposon as a genetic tool for new therapeutics, particularly against cancer. https://t.co/cvkj2ExmjR
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Nature research paper: Protecting double Holliday junctions ensures crossing over during meiosis https://t.co/NBc7Z3hbLg
nature.com
Nature - Conditional ablation experiments show that key components of the synaptonemal complex protect double Holliday junction recombination intermediates to ensure their resolution into crossover...
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in her 1983 nobel lecture, barbara mcclintock presciently described the origins of new species as the aftermath of accidental hybridizations stay tuned for tomorrow, as we stand on her shoulders
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Excited to share my talk at the EMBL John Kendrew Award ceremony about what transposons taught me about science, life, and change along the way. Big thanks to my mentors, @embl, and my current scientific home @MaxPerutzLabs 💛 https://t.co/rm3LKQ5CLl
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Wrapping up my @ERC_Research-funded @frontiers_media Fellowship at ISTA. In 4.5 months, I gave talks on science journalism, visited Austrian newsrooms, and connected with researchers and journalists from around the world. Grateful for the opportunity and excited for what’s next!
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1/16 New pre-print from the Sternberg Lab! We uncover how temperate phages can use RNA-guided transcription factors to remodel the flagellar composition of their bacterial host and enhance their fitness. Find the preprint and full story here: https://t.co/rh4PoOWn9l
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Temperate phages enhance host fitness via RNA-guided flagellar remodeling https://t.co/s2wzfo1wo2
#biorxiv_micrbio
biorxiv.org
Bacterial flagella drive motility and chemotaxis while also playing critical roles in host-pathogen interactions, as their oligomeric subunit, flagellin, is specifically recognized by the mammalian...
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Hi there! We are lookig for a highly motivated and talented postdoctoral researcher to join our dynamic team starting in 2026. Please see the call for more details! Come on join us! It will be fun! :)
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Excited to share my last major PhD work from the @SternbergLab. We discovered a mechanism that initiates transcription at programmable sites, without requiring promoter sequences - a novel mode of transcription regulation in bacteria.
New pre-print(s) from the Sternberg Lab in collaboration with @LeifuChangLab! We uncover an unprecedented molecular mechanism of CRISPR-Cas12f-like proteins, which drive RNA-guided transcription independently of canonical promoter motifs. Full story here: https://t.co/4eCvIxzGD4
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Excited to see our work published in @ScienceAdvances! We present RBPseg, a method for structural prediction of #phage receptor-binding proteins. We applied it to diverse tail fibers and validated the predicted structures using #cryoEM. Read here:
science.org
RBPseg enables accurate modeling of tail fiber structure, providing the first comprehensive tail fiber structure atlas.
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Exited to share that our RBPseg paper has just come out in @ScienceAdvances. Huge cograts to first author @VKleinSousa and co-authors @AritzRoa, @CloudyKielkopf and @sofos112
#phage #cryoEM #ArtificialIntelligence @UCPH_CPR
science.org
RBPseg enables accurate modeling of tail fiber structure, providing the first comprehensive tail fiber structure atlas.
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What’s it like to be a postdoc at the Vienna BioCenter? Anna Osnato shares her experience from joining the Institute of Molecular Biotechnology. The VIP³ PostDoc Program call is open – apply now for this unique opportunity! https://t.co/qoFIRhg7nB
#VBCPostDoc
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Tomorrow I’m joining four amazing colleagues from around the globe to talk about science journalism — how it can offer clarity, hope, and accountability in uncertain times. Don’t miss it! More info at: https://t.co/N8N00RVwaU
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A drug approved to treat migraine headaches can also alleviate debilitating non-headache symptoms, such as fatigue, brain fog and blinding light sensitivity https://t.co/OjMcjJYAuw
nature.com
Nature - Results from a phase III clinical trial suggest that taking ubrogepant at the first sign of an oncoming migraine can prevent pre-headache fatigue and light sensitivity.
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Great article about the bridge RNA discovery from @evandeturk! Very grateful that he took an interest in it and reached out to interview me and @ntperry13.
berkeleysciencereview.com
Expanding the genome editing toolbox
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We are looking for a PhD student/Postdoc to develop methods of cryo-ET and/or study the structure and function of membrane proteins. Great team at the MDC in Berlin. It's a broad call, please apply and share! https://t.co/GpB09mKnQz
jobrxiv.org
Post a job in 3min, or find thousands of job offers like this one at jobRxiv!
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Happy to have @IanaCamilla16 in our team!
Iana Hammerschmid @IanaCamilla16 from the University of Vienna (@univienna) joined @irma_querques lab to study the molecular mechanisms and regulation of transposons, aiming to develop advanced genome editing tools.
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These are words being made "illegal" in government by NON-ELECTED people. How many describe you and your loved ones? Remember: the Nazis came first for the Jews..who's next here?
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🎉 Our @diana__pinheiro is featured in a Women in Science book! The book, part of Ciência Viva’s initiative, celebrates Portuguese women scientists. The latest volume launches tomorrow, #InternationalWomensDay, in Lisbon. 📖 Read more: https://t.co/Z6MQRB36xo
#IWD2025
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