Holly Lee
@hollyleeYJ
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Clinician investigator program @Ucalgary. Multiple myeloma. Enjoy all things cell biology/ cancer immunology/ books/ memes. π°π·π¨π¦
Joined January 2018
We just heard from @hollyleeYJ (@UCalgary) at #iwGPRC5D2025, who gave a fascinating presentation on clonal evolution and its impact on GPRC5D antigen expression. #MMsm #HemOnc
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sBCMA, surface antigen density, effector-to-target ratio, and TCE dose collectively mediate primary refractoriness to anti-BCMA TCE. https://t.co/Xk4figyydx
#immunobiologyandimmunotherapy #lymphoidneoplasia #multiplemyeloma
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DO NOT MISS at this #ASH24 meeting the VERITAS for the understanding of the acquired resistance mechanisms to anti-BCMA T cell engagers in myeloma #msmm presented by @hollyleeYJ and David Jung. NO MORE ASSUMPTIONS!
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Weβre at the 21st annual International Myeloma Society meeting @Myeloma_Society #IMS24 where Dr Nizar Bahlis @NBahlis presented on genomic and immune signatures in newly diagnosed myeloma. (1/2)
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Our star MD PhD student Dr Holly Lee β¦@hollyleeYJβ© presented at IMS2024 her work on GPRC5D TCE resistance in myeloma
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Very excited to share with the myeloma community our latest work on the role of sBCMA and non-T cell factors on the resistance to anti-BCMA TCE β¦@BloodJournalβ©, work led by β¦@hollyleeYJ with Paola Neri, @FrancescoMaura4, https://t.co/YAS4vozktw
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Original Article: A Novel Anti-CD38 Monoclonal Antibody for Treating Immune Thrombocytopenia https://t.co/lu7ChwNWNn
#Immunology
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Janus kinase (JAK) inhibitors improve antitumor responses @ScienceMagazine @MMarmarelis @andyjminn @EJohnWherry @MdVeronika @Teijaro_Lab
https://t.co/ax7ojgVbQq
https://t.co/bN10E0CjH0
https://t.co/bN10E0CjH0
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Kim touched so many lives with her resilience, strength and grace. It was an honour to know her and work with her. Her legacy will live on in all her advocacy. https://t.co/B3RdHvsghg
donate.owncancer.ca
The Alberta Cancer Foundation acts as a beacon of hope by empowering and uniting Albertans around a common purpose, investing in the future of cancer research and care, and ensuring no Albertan...
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A subset of CD8 T cells with a terminally exhausted epigenetic profile expressed IFN-Ξ³, granzymes, and perforin in bone marrow @SciImmunology Congrats @simone_minnie! @Geoff_Hill_Lab @ScottFurlan
https://t.co/cKqNUlHLsr
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The MMRF Research Fellow Award Program supports early career researchers in multiple myeloma with $150K over 2 years. Meet Dr. Holly Lee, a 2023 awardee who published a review on bispecific antibodies in myeloma. Read about her journey and research impact:
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My Favorite Reading Quotes 1. βThe reading of all good books is like a conversation with the finest minds of past centuries.β β Descartes 2. βIf you only read the books that everyone else is reading, you can only think what everyone else is thinking.β β Haruki Murakami
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Thousands at #ASH23 eagerly learning from @NBahlis @UCalgary, Dr Sham Mailankody, & @SurbhiSidanaMD. Dr Bahlis is Chair of the Session: How Do We Apply T-Cell Redirection Therapy for Myeloma? CAR T-Cells and Bispecific Antibodies #mmsm @hollyleeYJ @NoemieLeblay @gabe_cola
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Come join us this morning at #ASH23 educational session with the Dr Sham Mailankody and @SurbhiSidanaMD to hear on "How Do We Apply T-Cell Redirection Therapy for Multiple Myeloma? CAR T-Cells and Bispecific Antibodies" Grand Hyatt - Seaport Ballroom ABCD 10:30am - 11:45am
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Excited to see this seminal work published today @BCD_AACR led by the talented Paola Neri and @BioBenBarwick on Transcriptional Plasticity Mediating IMiD /CELMoD Resistance in Multiple Myeloma https://t.co/qyfK6kZHc4
#msmm @UCalgary @UCalgaryMed @Charb_Cancer
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Kedzierska and colleagues performed single-cell transcriptomic and paired TCRΞ±Ξ² analyses to map epitope-specific CD8+ T cell immunity across the human lifespan ex vivo in newborns, children, adults and older adults. Read it here: https://t.co/RvT31zDvBO
https://t.co/zpGgDqxuwG
nature.com
Nature Immunology - Here the authors use single cell profiling of T cells across the human lifespan to show that a suboptimal TCR shift in T cells as we enter older age results in a molecular...
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Excited to share our work, which shows that T cells targeting a shared neoantigen eliminate acute myeloid leukemia, including cancer stem cells, in vivo in a disease-relevant model @forskningsradet @ERC_Research @OsloCancer @UiO_LifeSci @Oslounivsykehus
nature.com
Nature Cancer - Olweus and colleagues identify a T cell receptor reactive against the recurrent D835Y driver mutation in FLT3 in acute myeloid leukemia and show that engineered T cells against this...
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Out in today @NatureMedicine, https://t.co/TuvTDSldU6 FIH phase 1 trial with Elranatamab in R/R multiple myeloma defining the RP2D. High (ORR 64%) including in patients with high risk cytogenetics and prior anti-BCMA exposure. Responses were durable (DOR 17.1 mod, PFS 11.8 mod).
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