I made the mistake of uttering the words “let’s adjust the resolution to maybe 6, 7 and see what the data look like” in lab meeting today. Took me several minutes to work out why the room dissolved into giggles.

Microbiota-derived butyrate promotes a FOXO1-induced stemness program and preserves CD8+ T cell immunity against melanoma @ImmunityCP https://t.co/pWCC16KQV6 @TheDohertyInst @unimelb 🇦🇺

Congrats to PICI researcher Dr. @j_eyquem on the launch of Azalea Therapeutics! His PICI-supported work laid the foundation for Azalea’s approach to engineer therapeutic cells inside the patient: transforming cell and gene therapy. https://t.co/aHHnlAvhxT #PICI

Computational people, what is the usual timeframe from getting a brand new dataset to having publication worthy figures? (Assuming you have analysed the cell type before).

IL-15-induced bystander activation of human memory CD8+ T cells is suppressed by concurrent TCR signaling through NFATc1-AP-1 interactions @ImmunityCP https://t.co/NXmhRa8cCA 🇰🇷

But for real, I see academics pulling insane hours. I know what it takes to succeed here. I worked those hours as a grad student and postdoc. But I have a kid now, who I made on purpose and enjoy spending time with. How on earth can one be successful and be a present parent?!?

https://t.co/BoxPzNWNLT

Come join Nevada's first BMT/cell therapy! We are already super successful. We need another doc. I can only last so long doing Q2week call! We are helping patients in great need. I have never asked for a retweet, but colleagues please retweet. https://t.co/H9Xu1MdwSa

Happy Halloween from the Minnie Lab!

Cool! We have to get something out of it for ourselves after growing and sustaining an entire human with our bodies. Reduced risk of cancer? I’ll take it!

We posted this preprint to @biorxiv_immuno that focuses on the idea that CD8 T cells can naturally survey and eliminate stem-cells in the colon epithelium that have neoantigens that are created by somatic mutation. This work was spearheaded by Jess Buck in the lab!

Integrated epigenetic and genetic programming of primary human T cells https://t.co/ZlAhnB2IzI

Okay, but what if CD4 T cell help can give you effector function IN your exhausted T cells? Does that make the “exhausted” T cell just an effector? Is “exhausted” a phenotype or a functional state? Asking for a friend.

This weekend, I did zero work (reading a few papers doesn’t count). No writing. No emails. No data analysis. Just got (lightly) sunburnt and spent time with my family. I highly recommend recharge time!!

Optimizing post-transplantation cell therapies to enhance graft-versus... https://t.co/ToLUTG11YQ Was a joy to contribute to this review on immune-based approaches to improve GVL after allogeneic BMT.

This paper. Yes!! Proof of MM-specific T cells with beautiful functional assays + idiotype-specific responses. We were/are developing our own ag-specific gene signature for MM, but with less elegant techniques. I respect this scooping, can't even be mad. https://t.co/cTUIA1Uv0s

"Interruption of the intratumor CD8+ T cell:Treg crosstalk improves the efficacy of PD-1 immunotherapy":

Our immune system is an evolutionary masterpiece. Every day it protects us from the thousands of different viruses, bacteria and other microbes that attempt to invade our bodies. Without a functioning immune system, we would not survive. One of the immune system’s marvels is its

Half the internet hating Taylor's new album, while the other half listened to one song over 30 million times in one day, really tells you to just do you. Not everyone will like what you do, and that's okay....

Eomes controls the acquisition of regulatory and cytotoxic function in CD4+ T cells that are critical for limiting immune toxicity, while maintaining persistence and tumor control after immunotherapy @ImmunityCP https://t.co/Z8N7DZWyW2 @fredhutch @Geoff_Hill_Lab 🇺🇸