Gardner Lab
@gardnerlabUCSF
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News from Dr. James Gardner's lab @UCSF, @UCSFtransplant, & @Atucsf, focusing on advances in basic immunology and immune tolerance.
UCSF Parnassus
Joined November 2021
Congrats to my former @UCSF next door neighbor Sonja Schrepfer and colleagues on taking a key step towards restoring beta cell function in people with T1D without immunosuppression. This moves us towards a cure! @Sana_Biotech @NEJM @AtUcsf
Brief Report: Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression https://t.co/rBaLoR8ivH
@ttsorg | #WTC2025
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🌟Exciting ‼️@UCSF Transplant Surgeon Dr. Shareef Syed has been selected as an Associate Member of the @AmCollSurgeons Academy of Master Surgeon Educators. This Fall, he'll be officially inducted into the academy in Chicago. Congratulations, Dr. Syed🏅
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Achieving and maintaining harmony between the liver and the host immune system is critical for liver graft health. Dr. @SandyFeng8, Vice-Chair of Research has earned a $7.2M @NIAIDNews grant to decode the tipping point between calm and crisis in children with liver transplants‼️
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Just released our pre-print on bioRxiv for UNCOVERseq, an improved off-target discovery platform for Cas9 and base editors! Great collaboration with the awesome team at IDT @idtdna
https://t.co/o39DHgvuUi
biorxiv.org
The rapid development of CRISPR-Cas gene editing technologies has revolutionized genetic medicine, offering unprecedented precision and potential for treating a wide array of genetic disorders....
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‼️We’re happy to share that @UCSF Fellow Dr. Hillary Braun is staying in San Francisco and will be joining the Division of Transplant Surgery @UCSFTransplant as Assistant Professor of Clinical Surgery after completing her Abdominal #Transplant Surgery Fellowship👏👏
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CHOIR is officially published @NatureGenet. No more arbitrary decisions in clustering. Add this to your single-cell toolbox - it will save you so much heart ache. And now it can scale to millions of cells. Compliments of the very talented @cathrine_sant.
CHOIR is now online @NatureGenet! CHOIR is a new clustering method for single-cell data that evaluates whether clusters represent statistically distinct cell populations. CHOIR scales to millions of cells and works with single-/multi-omic data of any type! https://t.co/EKg20yMygH
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check out this amazing free software for flow analysis. say goodbye to flowjo.
A new version of https://t.co/Z6U6eEKVhQ is out! This version adds the ability to export FlowJo workspaces and ACS files. It adds features to make pipelines and gates more intuitive. Also, our FCS file editor can now remove and reorder parameters. Try it out now! #flowcytometry
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From “preprint” to “in press”! Congrats @MValdearcos @RachelLippert and the rest of our outstanding team. @AtUcsf @UCSF #microglia #hypothalamus Microglia mediate the early-life programming of adult glucose control: Cell Reports
cell.com
Valdearcos et al. show that microglia shape the hypothalamic perineuronal network during early postnatal life, ensuring that hypothalamic neurons projecting to the pancreatic β cell compartment...
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Proud of our fantastic @UCSFMedicine medical student Han Yin @hansyin96 who presented our combined supra-&infra-mesenteric robotic technique for mid D3 tumors #SAGES2025. A complex topic, masterfully delivered.👏🎉 @HPB_Surgeon @UCSFSurgery @UCSFGSResidency
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Spend some time reading the March Literature Watch "A trip down (obesogenic) memory lane" by Sarah Alshammery and Natasha M. Rogers: https://t.co/GHm1spaq48
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🚨Excited to share our latest work, now out in @NatureBiotech ! We introduce SEED-Selection, a powerful method that enables high-efficiency enrichment of T cells edited at multiple loci in a single step 🧵👇 🔗
nature.com
Nature Biotechnology - Primary T cells with multiple genetic modifications are rapidly isolated by negative selection.
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‼️Dr. Holger Willenbring, @UCSFLiverCenter Director and @UCSFTransplant Surgeon Dr. Garrett Roll explore AAV capsid prioritization in normal and steatotic human livers maintained by machine perfusion in their latest paper published in @NatureBiotech 👉 https://t.co/MbON3hHRT2
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Our final section, Cell Engineering🧫🧬 @HuiCharlotte of @j_eyquem/@yimmieg labs will start things off, followed by Lauren Tabor of the Bruno lab and Marta Borowska of the Garcia lab! We are stoked for our keynote Dr. Jennifer Doudna @doudna_lab 🤩 can’t wait to see you there!
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RT @BrisaPalikuqi: Please RT: 📢 Exciting Opportunity! 📢 The Brisa Palikuqi Lab at Yale Med is hiring a Postgrad Research Associate in Ste…
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Happy to share our new work describing DESynR genes! The evolution of new human protein-coding genes relies on repurposing protein domains from ancestral genes, rather than de novo sequence creation. New genes evolved from old parts, and while we have methods that enable
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Our latest paper with @Molofsky_lab is out! tweetorial to follow. Group 2 innate lymphoid cells promote inhibitory synapse development and social behavior | Science https://t.co/u2fQ2j2OeN
@jerika_barron @ Nick Mroz
science.org
The innate immune system shapes brain development and is implicated in neurodevelopmental diseases. It is critical to define the relevant immune cells and signals and their impact on brain circuits....
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In @JExpMed Tam, Cyster et al @UCSF report that a lymphoma-associated gain-of-function GPR34 variant promotes immune cell accumulation in the peritoneal cavity & demonstrate that this accumulation requires the lysophosphatidylserine-generating enzyme PLA1A https://t.co/Avd8zPO2YI
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Wanted to share our work - 3400 HCC patients with improving survival over time highlighting importance of surveillance & early detection. @UCSFSurgery @UCSFGSResidency @UCSFTransplant @UCSFLiverCenter @KPDOR @NCSP_UCSF
https://t.co/AiYbr5zesb
jamanetwork.com
This cohort study evaluates survival and the factors that shape clinical outcomes among patients with hepatocellular carcinoma in one of the largest integrated health care systems in the US.
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Keep up to date with the latest AJT Literature Watch: "Impact of short-term vegan versus ketogenic diets on human immunity and microbiome" by Horner et al. https://t.co/s9ZCwLSPe5
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Dr. Ascher is a pioneer in transplant surgery, who led ASTS as our President in 2000-2001! Please join us in saying congratulations to Dr. Ascher on her transition into retirement, and saying thank you for her incredible contributions to the field. https://t.co/Un3ygZKONd
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