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In @JGenPhysiol, Martínez-Lázaro et al. @ULL show that two GRIN2B variants disrupt nanoscale coupling betwn NMDA receptors & BK channels, revealing nanodomain dysfunction as a potential mechanism contributing to GRIN2B-associated pathophysiology

In @JExpMed, Lei Yuan, Chen Dong et al. reveal that ciliated cells play an immunoregulatory role in allergic #asthma by constitutively expressing IL-17D, which limits #monocyte recruitment to inflamed lungs. #MucosalImmunology #Inflammation #Cilia

New in @JExpMed: @vinitiwari1 & Mikael Simons review the relationship between lipid #metabolism & CNS #inflammation & how disruptions in this interplay contribute to neurological disorders #Neuroinflammation

New in @JGenPhysiol: Martin Heiss, Bernhard Flucher et al. unravel molecular mechanisms in a voltage-sensing domain that governs the kinetics and voltage dependence of calcium channel activation. #IonChannels

.@JExpMed August cover ( depicts the staining of proximal draining lymph nodes using multiparameter quantitative confocal imaging: OT-I T cells (pink), CD11c-expressing DCs (purple), & CD64-expressing monocytes (blue). Conlon et al

.@JCellBiol's August issue is here! The cover shows confocal #microscopy image of a #Xenopus laevis zygote in metaphase of the first embryonic #mitosis stained by immunofluorescence to visualize spindle. From Cantwell et al.

In @JExpMed, Metzemaekers et al. review how memory T cells fight infections & #cancer by retaining epigenetic “memories” that enable the rapid reactivation of inflammatory genes, and how such epigenetic mechanisms may fuel T cell dysfunction in disease

New in @JExpMed: Fu et al. identify biallelic germline ASXL1 variants as the cause of a novel #InbornErrorOfImmunity, linking ASXL1 deficiency to epigenetic dysregulation, combined immune deficiency, chronic viral infections, & malignancy.

Tony Harris spotlights @JCellBiol study from Kim et al. (, which identifies an inhibitory pathway that controls the formation of epithelial tubes during #Drosophila salivary gland #development:

New in @JExpMed: Shi et al. identify the type I BMP receptors ALK2 & ALK3 as critical mediators of T cell activation and activation-induced #CellDeath. The roles of ALK2/3 in these processes are interdependent & independent of their BMP ligands

STAT1-GOF is characterized by infections & #autoimmunity. In @jhumimmunity, Buddingh, Schuetz et al. report overall survival after allogeneic #HSCT in an international cohort of 36 patients is 72.2%, markedly improved from an earlier report.

In @JExpMed, Gern et al. show that the early interplay between #neutrophils & CD4 T cells is pivotal in determining #TB pathology, and that depleting neutrophils can improve outcomes even at late timepoints, which has therapeutic relevance

In @JCellBiol, @BenjaminPadman et al @LazarouLab outline a segmentation strategy for 3D FIB-SEM data from cells, termed AIVE, & identify a new type of mitochondrial contact called the mitochondrial intrusion

Scientist-philosopher & former @JExpMed editor René Dubos is the focus of a new e-book from @RockefellerUniv. The annotated bibliography by Carol Moberg covers his ideas on health, society, ecology, and humanity, all strikingly relevant today. More here:

📢 Now accepting applications for @JExpMed Early Career Travel Award, for grad students & early-career postdocs to participate in a scientific conference. This year, the award will support the attendance of #Cytokines2025 @cytokinesociety! Apply here 👉

📣 #CallForPapers 📣 @JGenPhysiol is inviting submissions on the topic of the EpIC meeting, “Emerging Research on #IonChannels in Health & Disease” – w/ Guest Editors Jelena Baranovic, Osama Harraz, Conor McClenaghan, & Lejla Zubcevic 👉

RT @LSAjournal: Novel open-source diagnostic tool offers affordable, reliable pathogen detection for resource-limited settings. Read the ar….

.@JExpMed's latest #CME activity @MSKCME is now available! ✍️💻.New content 📄: “Epitope and HLA specificity of human TCRs against Plasmodium falciparum circumsporozoite protein” by van Dijk et al. (. Begin the CME here 👉

.@JGenPhysiol's July issue is here! The cover image highlights the voltage-gated sodium channel NaV1.8 and its targeted drug Journavx, illustrating their role in pain perception and therapeutic intervention. From Wood et al.