Driti Ashok
@driti_ashok
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Adventure Seeker Doctoral candidate @ the University Medical Center Freiburg LMU München | MSc. Molecular & Cellular Biology👩🏻🔬 Opinions are personal
Freiburg im Breisgau
Joined March 2020
Review Alert🔔: Check out our article that discusses the indispensability of adhesion-dependent & metabolic cues in shaping the bone marrow microenvironment. 😃🥳!! @FrontCellDevBio @OpenAcademics @UniFreiburg
https://t.co/5J6BlOormg
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Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy @Nature
https://t.co/d93POyu7oG
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New paper from my lab! Elevated mitochondrial membrane potential is a therapeutic vulnerability in Dnmt3a-mutant clonal hematopoiesis: https://t.co/7oRvnKFhF2 Complementary to new work from Steven Chan & George Vassiliou as described by @Goodell_Lab:
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I am honored to have been selected by my colleagues to serve a 4-year term as vice president & president of the International Society of Experimental Hematology. Now, as ever, uniting, empowering and inspiring our collective scientific community to press on is essential.
The results are in 🗳️ Congratulations to our incoming 2025-2026 Board of Directors who will start their terms at the conclusion of #ISEH2025🏯 in September! 👏
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When did the taste of the scientific community changed from liking simple elegant experiments to preferring complicated and expensive experiments?
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Day 1 at ASH going strong 👍🏻! Do check out my PhD work today at poster # 1298 titled “SPARC Stabilizes Integrin α4-VCAM-1 Interactions and Is Regulated By Intracellular Rac in NPM1-Mutated AML”. Happy to network with fellow researchers and professionals in the field. #ASH24
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Thrilled to be on my way to ASH for the very first time :) Can’t wait to learn, connect and share!! See you soon! #ASH2024 #hematology #HemeSky
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This paper changes everything in the AML field. This is the best model of the most frequent and aggressive acute myeloid leukemia. When we beat this disease, we will look back at this paper as marking the beginning of the end. @bowman_rl @rosslevinemd
https://t.co/JNYN8Dvt4r
cell.com
Bowman et al. develop orthogonal DNA recombinase tools to sequentially and reversibly control somatic mutations in leukemic evolution. These approaches identify how mutation timing and order influe...
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I’m excited to share an R package that we’ve created for mapping scRNA-seq data across normal and malignant hematopoiesis! We've used this to identify hematopoietic stem cells from healthy tissues and map leukemia cells from hundreds of patients. 1/6 https://t.co/NW4aMMFUsx
github.com
A single cell RNA-seq reference map of human hematopoietic development in the bone marrow, with balanced representation of hematopoietic stem and progenitor cells and differentiated populations - a...
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Our study uncovering a new mode of how growth factors exert their effect on cell state via modulation of nuclear mechanophenotype is live - check it out! #mechanobiology #nucleus
How do #stemcells integrate information to make fate decisions? Check out our latest preprint where we find that growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to determine whether to retain or exit #pluripotency🧵👇 https://t.co/CB1vIDUFbX
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Breakthrough in Acute Leukemia Treatment 🩸 🔬Prof. Irmela Jeremias & team (@Jeremias_lab) at #HelmholtzMunich discovered a potential game-changer for acute #leukemia #therapy: the ADAM10 surface molecule. 👉More info: https://t.co/vXKyc38Zjz 💡Targeting #ADAM10 could help
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#SCC2023HD was an absolutely fantastic meeting - a supercharged science about trends and future perspectives in stem cell biology! Congratulations to Andreas, Carsten and all the organizers at @hi_stem_lab and @DKFZ @uniklinik_hd @LabTidow....Science Rocks!
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🔬 Dr. Irmela Jeremias (@Jeremias_lab) and team at @HelmholtzMunich identify ADAM10 as an attractive therapeutic target for the future treatment of acute #leukemias. They used combined proteomics and #CRISPR‒Cas9 screens in patient-derived xenografts. 🔗 https://t.co/mV7ztG1AJN
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Join us tomorrow, Tue 28th for some exciting science on #integrins and the #extracellularmatrix
Join our next @DGZ_info focus workshop on "Cell Adhesion and Extracellular Matrix", organized by Carsten Grashoff @WWU_Muenster and @WickstromLab with presentations by @IvaskaLab, @RaphaelReuten, Federica Pennarola @CavalcantiAda and Luis Henrique Correa from the Sorokin lab.
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Preprint and song: Minimal mathematical model cuts through the complexity of fibrosis to reveal a therapeutic target that reduces scarring in mice after heart attack. @Tzahore @MiyaraShoval @MiriAdler @RMedzhitov
https://t.co/DvT9OPPGbR
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💫ONLINE NOW @NatureCancer “Potent high-avidity neutralizing antibodies and T cell responses after COVID-19 vaccination in individuals with B cell lymphoma and multiple myeloma” by #OliverTKeppler & Co. Read it here 👇 https://t.co/sg7NrXZM8h
https://t.co/7YEzvEWXqF
nature.com
Nature Cancer - Keppler and colleagues show that individuals with hematological cancers rapidly develop potent infection-neutralizing antibodies and a robust T cell response against several...
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Delighted to share our new paper published today in @JCO_ASCO, demonstrating the value of #ctDNA as a biomarker for noninvasive disease identification, risk-stratification, and monitoring in patients with CNS lymphoma.
ascopubs.org
PURPOSEClinical outcomes of patients with CNS lymphomas (CNSLs) are remarkably heterogeneous, yet identification of patients at high risk for treatment failure is challenging. Furthermore, CNSL...
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Thank you @Ludwig_Cancer for including me as you shine a light on #LudwigWomenLeaders!
Ludwig @MIT’s @snbhatia speaks about childlike curiosity as fuel for a scientific career, her advocacy for women as scientists and entrepreneurs and her emphasis on making science fit her life—not the other way around. https://t.co/JgFykrAWs7
#LudwigWomenLeaders
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Does a cell's size matter? In our review we attempt to connect the dots between different cell types and Aging-related pathologies @FrontCellDevBio
#cellsize #aging
😃 First review of our lab: Cellular enlargement - A new hallmark of aging? We highlight the “hidden” connection between #cellsize and aging-related pathologies in many cell types. @FrontCellDevBio 👉Link: https://t.co/MFnj5jlgFc Please RT. See more: https://t.co/8p9GcQvfoQ
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I'm SO EXCITED to share our new pre-print! 🥳 You finally got your RNA-seq data. You open RStudio, stare at the screen for 5 mins...And realize you don't even remember how to import a table. How will you analyze your data?!😱We're here to help! A 🧵👇(1/9)
biorxiv.org
Background Amongst the major challenges in next-generation sequencing experiments are exploratory data analysis, interpreting trends, identifying potential targets/candidates, and visualizing the...
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Have you ever wondered whether your single cell transcriptome represents really only one tiny cell? Here, we get genotype based estimates of background RNA allowing us to estimate its effect on analysis and to benchmark background removal methods. https://t.co/qtMutknY68
#SCOG
biorxiv.org
BACKGROUND In droplet-based single-cell and single-nucleus RNA-seq experiments, not all reads associated with one cell barcode originate from the encapsulated cell. Such background noise is attribu...
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