
Mike Spencer Chapman
@doctor_msc
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Haematology doctor & researcher, UK. Interested in blood ageing, transplant, cancer and development. Lapsed musician.
N 51°27' 0'' / W 0°6' 0''
Joined October 2011
Thank you HaemStar! It was a great day, lots of exciting & motivating talks - really recommend future events to all haem trainees/ those interested in choosing haem training.
Fair to say we were all blown away by the incredible work of @doctor_msc. Taking us back to science basics with his work on phylogenies and clonal dynamics. A truly dynamic and captivating talk! Thank you so much for joining us at #haemSTAR25
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RT @S_J_Aitken: @doctor_msc @mst_paralogue Congratulations on your elegant paper! It's great to see #LesionSegregation being identified in….
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RT @TimePieChina: In a paradigm shift in how we view mutations, researchers uncover forms of DNA damage in healthy cells that can persist u….
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RT @sangerinstitute: DNA damage can go unrepaired for years, which can create multiple chances to generate harmful mutations that could lea….
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A huge thank you to Peter Campbell, my supervisor whose insights were vital to getting this study started. When I showed him the 1st unexpected mutation he said (typically) ‘I wondered if this might happen. ’ Also, thanks to @imartincorena & @TimCoorens for valuable input.
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Also, the whole idea of these persistent lesions builds on the concept of 'lesion segregation' observed (again, unexpectedly) and developed by @S_J_Aitken @mst_paralogue and team.
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This discovery science is only possible thanks to the large-scale somatic phylogeny datasets re-analysed here, generated by @Emily_LMitchell @StanleyWKNg @WilkMatthias @TheBoettcherLab @ken1_yossy @jyoti_nangalia & others, funded by @CR_UK @sangerinstitute @wellcometrust +others.
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In science, we often see weird blips in the data. The question: is it artefact (usually!), or something new & exciting? We don’t always have time to dig deep. Our paper in @nature today came from just such a blip. So don’t ignore the weird stuff. Pull on that thread.
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RT @S_J_Aitken: Building on our discovery of #LesionSegregation, @doctor_msc and colleagues from @sangerinstitute find that some DNA lesion….
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Fascinating stuff! Lots to learn about these structures. Congratulations Chris! 🎉.
Hot off the press!! 🔥 Check out our work on the origins and impact of ecDNA. This was a team effort involving multiple collaborators as one of a three part series on ecDNA in @Nature.
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