Boettcher Lab
@TheBoettcherLab
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Assistant Professor @UZH_en & @Unispital_USZ studying the molecular pathogenesis of cancer with a particular focus on TP53-mutant myeloid (pre-)malignancies
Zurich, Switzerland
Joined May 2019
Thanks to all colleagues, friends, mentors - especially Ben Ebert @DanaFarber, @broadinstitute, @BrighamWomens – for their contribution to this study! https://t.co/dOt9Hlxq5R
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REGISTER NOW! 🚨🚨 Spots are filling up for the first EMBO workshop on Single cell Lineage Tracing 2025!! Sept 18-21 in Girona, Spain. Tons of opportunities for talks (short and full length) still available!!! https://t.co/5zyDYe4ZaU
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https://t.co/2qEO2bM9Rk Amazing landmark work from @Goodell_Lab and @jyoti_nangalia Very intriguing results and lots to discuss!
nature.com
Nature - Isolating and studying haematopoietic stem cells in young and aged mice demonstrates evolutionary processes related to blood production and provides a framework for interpreting future...
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The 9th Zurich Immuno-Oncology Symposium is happening this Friday in Zurich. We will have outstanding speakers and a lot of cellular and molecular #immunotherapy, #CellTherapy, #CARTCell, and #geneediting. Register here for on-site/online participation:
usz.ch
The USZ regularly organizes regional, national or international events. Both professional and public events. Professional events & public events
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Online First: Increased clonal hematopoiesis in long-term survivors of pediatric hematopoietic cell transplantation https://t.co/Irif3oAUTw
#CHIPsm #clonalhematopoiesis
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In science, we often see weird blips in the data. The question: is it artefact (usually!), or something new & exciting? We don’t always have time to dig deep. Our paper in @nature today came from just such a blip. So don’t ignore the weird stuff. Pull on that thread...
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A necessary reminder!
Hugues de The and I want to remind you that nothing has cured more cancer patients than conventional chemotherapy!!! Think you understand how it selectively kills cancer cells so well? Take a look inside. @DanaFarber @DanaFarberNews
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@TheBoettcherLab had a great time @ASH_hematology #ASH24 Now it’s time to say goodbye and gone home to @Unispital_USZ @UZH_en @CCCZ_USZ. CU next year
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privilege to present our in vivo CRISPR screen identifying ferritinophagy as a dependency in tet2 ko CHIP! Thanks to Ben and colleague Peter Kim and all the lab for helping drive the study ! funders @CRUKresearch @AACR
@unibirmingham @unibirm_CMH
https://t.co/7IPqOSLJji
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Congratulations to @RomanSchimmer from my lab @Unispital_USZ @UZH_en @CCCZ_USZ presenting his data on somatic #TP53 mutations in #ERCC6L2-mutant IBMFS 👏🍾🎉
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HSPC defect caused by E6L2mutations is completely rescued upon acquisition of additional TP53 mutations-lead to increased potential for malignant transformation. #ASH24
#BMFCases at #ASH24 Roman R. Schimmer, MD, examines how somatic #TP53 mutations rescue stem cell defects in #ERCC6L2-associated bone marrow failure, raising #myeloidmalignancy risk. Saturday, Dec 7, 2024 | 2:00 PM @ASH_hematology #HemeTwitter #MedTwitter
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Congratulations to #Jonas Fullin from my lab @Unispital_USZ @UZH_en @CCCZ_USZ presenting his data on #TP53 allelic states in #AML #ASH24 @ASH_hematology 👏🎉
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First look at #ASH24, the the premier event in classical and malignant #hematology! We can't wait to see everyone.
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#BMFCases at #ASH24 Roman R. Schimmer, MD, examines how somatic #TP53 mutations rescue stem cell defects in #ERCC6L2-associated bone marrow failure, raising #myeloidmalignancy risk. Saturday, Dec 7, 2024 | 2:00 PM @ASH_hematology #HemeTwitter #MedTwitter
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🎉 #ESHBMFS2024 Many thanks to @CarmemBonfim1, @brummendorf, A. Risitano & @SharonSavageMD, to the faculty & to all the participants for this great 3-day conference in Paris 🇫🇷 Our last event of the year! See you in 2025 for the next #ESHCONFERENCES ➡ https://t.co/ciJQdWyN8v
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Proud PI moment: Dr.@RomanSchimmer @Unispital_USZ @UZH_en @CCCZ_USZ presenting his data on #ERCC6L2-mutant IBMFS and secondary #AML #ESHBMFS2024 Congratulations!🙌 @ESHaematology
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Very Last Check before #ESHBMFS2024 is up an runing in half an hour. Very much looking forward to three days of great scientific exchange and meeting colleagues and friends in the City of light #Paris
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📰 Read ‘Clonal dynamics after allogeneic haematopoietic cell transplantation using genome-wide somatic mutations’ with @sangerinstitute @UZH_en @AnthonyNolan @CR_UK and others in @Nature ⤵️ https://t.co/BtutMFZvoG
nature.com
Nature - Uprooting stem cells from their native environment and transplanting them to other individuals exaggerates selective pressures, distorting and accelerating the loss of clonal diversity in...
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Blood stem cell transplantion or 'haematopoietic cell transplantion' (HCT) is unusual amongst transplants as the donor blood/immune cells get into every tissue, even semen - which can cause issues for forensic investigations! https://t.co/vFLhfHeo0w
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