Martin Taylor
@mst_paralogue
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Genome biology and evolution | computational genomics | mutations are important
Edinburgh, Scotland
Joined May 2011
New preprint on @biorxivpreprint Symmetry of translesion synthesis on leading and lagging strands (small adducts) Disentangle damage from repair Mutagenic NER + more https://t.co/MWUrmKHNFA thanks to @S_J_Aitken @odom_lab @craigandersn Lana and LCE
biorxiv.org
DNA base damage is a major source of oncogenic mutations[1][1]. Such damage can produce strand-phased mutation patterns and multiallelic variation through the process of lesion segregation[2][2]....
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Now out @Nature, our paper on HiDEF-seq: single-molecule DNA sequencing that resolves single-strand changes (mismatches and damage)!
nature.com
Nature - A DNA sequencing method with single-molecule fidelity detects mismatches and damage present in only one of the two DNA strands with patterns that are both similar and distinct compared to...
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🎉New paper🎉Introducing #StrandInteractions, the sequel to #LesionSegregation, published today @Nature Strand-resolved mutagenicity of DNA damage and repair https://t.co/VTP3h139Q4 Here’s what we discovered about (a)symmetry in replication, transcription & #mutagenicNER [1/13]
nature.com
Nature - How strand-asymmetric processes such as replication and transcription interact with DNA damage to drive mechanisms of repair and mutagenesis is explored.
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Today is the last day of abstract submission for Mutations in Time and Space. https://t.co/HTcadDuQmt Join us in stunning Edinburgh, 23-25 April 2024, to present your latest research.
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I'll be at the GRS and GRC on Mammalian DNA Repair 2023 with a poster on lesion segregation and muliallelism. Come and find me for a chat!
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Tomorrow, John Connelly will be sharing his exciting new #pathomics findings: "Using #MachineLearning and #ComputationalPathology to explain unexpected genomic variation" Still time to register for this hybrid event @RCPath: https://t.co/OuMSvtxOJy
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Apply by January 9 2023 for our #PhD programme in Human Genetics, Genomics and Disease. Join us in Edinburgh to develop your research career and tackle key problems in understanding how our DNA affects health and disease @EdinUni_IGC
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🧬Are you interested in DNA, mutations, and keeping patients safe? 🧑🏿🔬We're looking for a curious, smart, ambitious, team player to join us in October 2023 💊@AstraZeneca-Funded PhD Studentship with industrial placement 🗓️Closes: 05 Dec 2022 https://t.co/v1KkBjb0CS Please RT!
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A great opportunity...
Computational postdoc: Investigating the biological basis of indel cancer signatures Further details: https://t.co/FLBeEwy2xg Research group: https://t.co/Ue3rVmTAIu Informal enquiries to: andrew.jackson@ed.ac.uk Closing date: Wednesday 9th November
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Now that I've had a chance to see peoples' questions about @eLife's new publishing model, time for a thread for a thread with some details and answers. https://t.co/tD1BovOzLd
elifesciences.org
eLife is changing its editorial process to emphasize public reviews and assessments of preprints by eliminating accept/reject decisions after peer review.
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..and check out the Alumni from the Edinburgh Scientific Academic Track, who now have open-ended faculty positions.
We are recruiting 30 - yes, that's right, 30! - Chancellor's Fellows to prestigious, tenure-track, research-intensive early/mid-career roles at the University of Edinburgh. Please spread the word!
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We are recruiting 30 - yes, that's right, 30! - Chancellor's Fellows to prestigious, tenure-track, research-intensive early/mid-career roles at the University of Edinburgh. Please spread the word!
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⏰One week left to apply for the postdoc position @aitken_lab @MRC_TU @Cambridge_Uni
https://t.co/iXEdU4rIMA
🧑🏾🔬We're looking for an ambitious, curious, smart, team-playing #postdoc to join @aitken_lab @MRC_TU @Cambridge_Uni 🧬DNA damage, mutagenesis, genome biology, (spatial) genomics 🌍New labs in central Cambridge 🗓Deadline: 24 Oct 2022 📩Apply: https://t.co/ni6wW1Qkys Please RT
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It took a few years, with a global pandemic and transatlantic relocation in the middle of it. But finally, our manuscript on how UV irradiation remodels the specificity landscape of transcription factors is on BioRxiv https://t.co/tbWxA9w2hX. Huge thanks to...
biorxiv.org
Somatic mutations are highly enriched at transcription factor (TF) binding sites, with the strongest trend being observed for ultraviolet light (UV)-induced mutations in melanomas. One of the main...
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🧑🏾🔬We're looking for an ambitious, curious, smart, team-playing #postdoc to join @aitken_lab @MRC_TU @Cambridge_Uni 🧬DNA damage, mutagenesis, genome biology, (spatial) genomics 🌍New labs in central Cambridge 🗓Deadline: 24 Oct 2022 📩Apply: https://t.co/ni6wW1Qkys Please RT
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Earlier this week, John Connelly and Jose Coelho-Lima both gave talks at #ECP2022Basel Here is John's brilliant talk on "Predicting genetic variation from quantitative tissue phenotypes using explainable machine learning" #MachineLearning #DigialPathology #GenomicPathology
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Our preprint about the role of POLD1 deficiency in soma and germline mutations is out. https://t.co/wXq3PDrQyM Two main findings: surprisingly, POLD1 deficiency has a recessive effect on mutation rate; POLD1 alters mutational spectra to the same degree in soma and sperm
biorxiv.org
Mutational processes in germline and in somatic cells are vastly different, and it remains unclear how the same genetic background affects somatic and transmissible mutations. Here, we estimate the...
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Converging view that nucleotide excision repair is often the source of mutations. Found in bacteria https://t.co/LwZKXL6ayq, cancer https://t.co/lkHyaRhGk1 and building on insights from yeast https://t.co/jQmiHQXwZg.
@merrikh_houra @biorxiv adds bacterial and evo. perspective
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