Daniel Baker
@daniel_baker_j
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Getting my PhD @Penn | Taking CAR Ts beyond cancer w/ @carlhjune & @AranyLab
Joined February 2023
We, the Weizmann Institute of Science community, deeply mourn the passing of Prof. Zelig Eshhar of the Department of Immunology and Regenerative Biology. Prof. Eshhar was a trailblazing scientist in the field of cancer immunotherapy, a recipient of the Israel Prize in Life
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LIVE NOW: FDA's Cell and Gene Therapy Roundtable Captions available here: https://t.co/QyRYlaur9t
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Excited to share my PhD thesis work with @CarlHJune now out as a preprint on bioRxiv! We show that engineering IL-9 signaling enhances CAR T cell antitumor efficacy by steering them toward potent memory and effector states. https://t.co/DY32T5dAiT
biorxiv.org
The success of chimeric antigen receptor T cell therapies targeting solid tumors is limited by the immunosuppressive tumor microenvironment. We demonstrate that endowing CAR T cells with ectopic...
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Grateful to be named a 2024 RISE Scholar by @parkerici, alongside this incredible group of researchers driving advancements in cancer immunotherapy. Honored to be part of this effort toward a future where all cancers are curable!
We are thrilled to share the 2024 class of Representation in SciencE (RISE) Scholars, a group of seven exceptional researchers selected through our Diversity, Equity, Inclusion and Belonging (DEIB) Program. Read our latest blog:
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Published today @NatureBiotech: @CarlHJune and I reveal how CAR T cells are finally tackling solid tumors! @PennPPA @PennMDForum
https://t.co/wJkfMfVxgC
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Congratulations to the 6 @Penn @PennMedicine honorees elected to the National Academy of Medicine! Election to @theNAMedicine is considered one of the highest honors in the field of health & medicine. Check back this week as we profile each new member https://t.co/QtzEtsuw1d
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It's exciting that we are now seeing multiple different groundbreaking interventions towards curing autoimmune diseases. Here's one path https://t.co/4GfoTnYsKR
@Nature
nature.com
Nature - The treatment’s success in three people raises hopes for mass production of cutting-edge CAR-T therapies.
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In the latest issue! Off-the-shelf CAR-T cells could prove paradigm shifting for autoimmune diseases
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The remarkable mechanisms of SGLT2 inhibitors #heartdisease A robust specific off-target activation of PANK1 by SGLT2i promoting CoA synthesis and efficient fuel use in human hearts, a likely explanation for the clinical benefits of SGLT2i. https://t.co/6MsPEpPqFD
@AranyLab
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Published today @PNASNews: We’ve combined CAR T cells with proton radiation! Great collaboration between @Costas_Koumenis and @CarlHJune labs. @YVerginadis @PennPPA @PennMDForum
https://t.co/pLByQNxXBh
pnas.org
Pancreatic ductal adenocarcinoma (PDAC) represents a challenge in oncology, with limited treatment options for advanced-stage patients. Chimeric an...
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Check out our latest paper, published @NatureComms. We show that STING activation induces IL18 secretion and thereby enhances CAR T function. Great collaboration between @CarlHJune lab and James Chen @UTSWMedCenter. @PennMedicine @PennMDForum @PennPPA
https://t.co/zkWtZxdoRw
nature.com
Nature Communications - It has been previously suggested that STING agonists can improve response to CAR-T therapy. Here the authors report the characterization of the STING agonist IMSA101,...
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New study in @PNASNews from @CarlHJune, MD, Center Director for PICI Center @PennMedicine, and team reveals TP53 isoform Δ133p53α bolsters T cell fitness & reinvigorated CAR T cells from #CLL patients who previously didn't respond. https://t.co/nFu1E3eRDR
#immunotherapy #leukemia
pnas.org
Chimeric antigen receptor (CAR) T cell dysfunction is a major barrier to achieving lasting remission in hematologic cancers, especially in chronic ...
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It was great to speak with @bradloncar @BiotechTVHQ about my thesis work in @carlhjune’s lab and about the initiative @KristenHege started to support early career women here at the Center for Cellular Immunotherapies
UPenn: How @Penn PhD student @FinckAmanda is working in a world-class cellular immunotherapy lab. Link: https://t.co/yKN6i0eZxE
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🩺 @PennMedicine spotlight: last night we recognized Dr. Carl June, the Director of the Center for Cellular Immunotherapies at the Perelman School of Medicine, and Director of the Parker Institute for Cancer Immunotherapy at the University of Pennsylvania. Dr. June is joined
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Judy Campisi was an extraordinary person and though her loss cannot be overcome, here is a piece on her that will lift your day. https://t.co/Tcq5q1UCZf
science.org
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Autoimmune disease is the next frontier for CAR T cell therapy. News feature by @edbites
https://t.co/iH4nbccgd2
nature.com
Nature Medicine - CAR T cell therapy has transformed the treatment of B cell cancers and is now being pursued by biotech companies for conditions as varied as systemic lupus erythematosus, diabetes...
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Our latest review on peripartum cardiomyopathy #PPCM in @NEJM this week -- review of mechanism, genetics, clinical management, epi and prognosis -- lots of unknowns, huge racial disparities. Hope you enjoy it!
nejm.org
The author discusses the epidemiology and clinical presentation of peripartum cardiomyopathy, as well as the mechanistic basis for potential therapeutics.
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Meet @jonepstein1, the new interim dean at Penn’s Perelman School of Medicine https://t.co/NbojNFzT6U via @phillyinquirer
inquirer.com
Epstein, 62, trained at Harvard and has been at Penn since 1996.
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Want a comprehensive picture of fuel use (all of them) and #flux during cold exposure, in whole organism, using in vivo 13C tracing? check out our new paper in @Cell_Metabolism: https://t.co/SEFJqX6Kgh. MD-PhD star Marc Bornstein led the charge; great collab w Rabinowitz lab.
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Excited to share my Ph.D. work in @carlhjune lab showing uninhibited CD28 co-stimulation via CTLA4 disruption invigorates dysfunctional CART cells https://t.co/vTZJzH3IST
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