Pankaj kapahi
@kapahi_pankaj
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Professor at Buck Institute & UCSF | senior editor E-life | dietary restriction, TOR, glycation, aging, senescence. founder https://t.co/IxnVyV6yRE
California, USA
Joined August 2018
We show a novel role for glycogen in neurons in protection against dementia. Glycogen accumulation is seen in fly, iPSC and human post mortem samples of Alzheimer’s disease. Breaking down glycogen rescues tauopathy by reducing ROS by enhancing PPP.
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RT @prof_horvath: Some people misunderstand this tweet. The study suggests that vigorous exercise has a transient effect on the DNA methylo….
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RT @prof_horvath: The geroscience community has been buzzing, and we finally have informative data on semaglutide (a GLP-1 RA) and epigenet….
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A glimmer of hope for science! With boost to NIH budget, Senate panel rejects Trump’s plan to slash agency | Science | AAAS
science.org
Republicans on spending committee push back against proposed reorganization and overhead cuts
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RT @maxdkozlov: The NIH budget would INCREASE by $400m — not slashed by 40%, as Trump proposed — in a proposal by Senate appropriators, say….
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RT @RudyTanzi: Happy to co-author another new paper today in Science Translational Medicine with our close friend and colleague, Tae-Wan Ki….
science.org
An analysis of cell-cell communication in Alzheimer’s disease reveals insights into disease biology and potential therapeutic targets.
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RT @OdedRechavi: 🥂This was the highlight of my year. The "instigators", led by local master of the ceremony.@SvobodaLab .will never forget….
nature.com
Nature - Woodstock Bio2 + Night Science aimed to encourage collaborations through creativity. The walk-on music for presentations was fun, too.
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RT @ItaiYanai: 🚀Today we're launching the 'Night Science Institute', a non-profit to lead a cultural shift in science! You may say we're dr….
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RT @jpsenescence: New preprint with our list of 100 open problems in ageing science. Our curated list captures both long-standing fundamen….
arxiv.org
The field of ageing science has gone through remarkable progress in recent decades, yet many fundamental questions remain unanswered or unexplored. Here we present a curated list of 100 open...
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RT @agingdoc1: Open problems in ageing science: A roadmap for biogerontology. @jpsenescence . .
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RT @LammingLab: Congrats to @PekkaKatajisto for this cool paper "Old mitochondria regulate niche renewal via α-ketoglutarate metabolism in….
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Rethinking Brain Sugar — How Glycogen Shapes Tauopathy and Neuroprotection #.Here is a blog article we wrote on our recent study showing how tauopathy drives glycogen accumulation to set up a positive feedback loop driving neurodegeneration.
communities.springernature.com
Alzheimer’s disease is characterized by the buildup of toxic proteins, and lifestyle factors such as diet may influence the risk of developing the condition.
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RT @LapierreLab: Use of SRS to see vitellogenin accumulation during aging. However, our lab identified transcriptional reduction of vitello….
biorxiv.org
The molecular mechanisms of aging are not fully understood. Here, we used label-free Stimulated Raman scattering (SRS) microscopy to investigate changes in proteins and lipids throughout the lifespan...
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RT @americanaging: AGE Fellow Spotlight: Dr. Andrzej Bartke.A pioneer in aging biology, Dr. Bartke was first to show that a single gene mut….
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RT @AdrianoAguzzi: We implemented a no-screens policy during the weekly lab meeting. Phones+laptops are banned. It's early days but (1) the….
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RT @AgingJrnl: 📢#CallforPapers: Aging (Aging-US) invites #submissions on cellular #senescence - its mechanisms, functions & clinical applic….
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RT @AdrianoAguzzi: Some students can be ridiculously hypersecretive about their research (like concealing gene lists that are anyway in the….
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RT @DKThomp: Yes. Writing is not a second thing that happens after thinking. The act of writing is an act of thinking. Writing *is* think….
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RT @eLife: Neuroscientist @magdalenasolyga shares how eLife helped her avoid reviewer overreach, accelerate publication, and reach the righ….
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