King Lab
@KingLabIPD
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News from the King Lab @UW. Part of @UWproteindesign and @UWBiochemistry. Some assembly required.
Seattle, WA
Joined June 2018
🚨new paper alert🚨 Here, we show how recently developed ML tools can be leveraged to design self-assembling protein nanoparticle immunogens in the absence of experimentally determined structures of the oligomeric building blocks. Read more @PNASNews: https://t.co/ZTaO9m1X4x
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🚨 new paper in @ScienceTM 🚨 Here, we describe and evaluate a "best-of-both-worlds" vaccine technology platform that combines the benefits of mRNA vaccines and computationally designed protein nanoparticle immunogens: https://t.co/E7jl0fYInN.
science.org
Genetic delivery of designed protein nanoparticles displaying the SARS-CoV-2 RBD elicits potent neutralizing antibody and CD8 T cell responses.
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mRNA vaccines 🤝 designed nanoparticle immunogens
This week's issue of #ScienceTranslationalMedicine has arrived! New mRNA vaccines generate self-assembling nanoparticles to enhance immunity, dual-targeting "decoys" prevent metastasis and potentiate immunotherapy against melanoma in mice, and more. https://t.co/mfA8HqzCYv
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Couldn't have asked for a lovelier day to break ground in our new lab downtown!🌞
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Thanks to Aia, Syed, Dixie, and James for joining us this summer as Rosetta Commons Undergraduate Researchers! We loved working with you these past 10 weeks and wish you the best as you head back home!
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Another day, another @biorxivpreprint! Here, we show how new machine learning tools can be leveraged to design new self-assembling protein nanoparticle immunogens in the absence of experimentally determined structures of the building blocks.
biorxiv.org
Self-assembling protein nanoparticles are being increasingly utilized in the design of next-generation vaccines due to their ability to induce antibody responses of superior magnitude, breadth, and...
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🚨 New paper alert! 🚨 Here we show that stabilized influenza hemagglutinin HPAI H5 immunogens improve the quality of elicited antibody responses. Thank you to @open_phil for funding this work!
biorxiv.org
Transmission of highly pathogenic avian influenza from H5 clade 2.3.4.4b has expanded in recent years to infect large populations of birds and mammals, heightening the risk of a human pandemic....
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You can also learn more in the most recent @UWproteindesign blog post:
ipd.uw.edu
Protein design is expanding from building single molecules to generating entire systems from scratch with parts that work together in ways nature never explored.
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🚨 new paper alert 🚨 We present a method for designing protein nanoparticles with two unique faces that can bring together distinct biological targets at controlled distances! This project was led by Dr. Sanela Rankovic is out now in Nature Materials: https://t.co/Vkxk9N9wfT
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We’re looking for early stage investigators (Sr. Postdocs, Instructors, Asst Profs, etc) to join our ReVAMPP Center designing vaccines and antibodies against paramyxoviruses and bunyaviruses! Read more and apply here:
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The IPD is hiring a new Assistant to the Director! This role provides complex administrative support to IPD leadership and is crucial to keeping operations running. Apply today!
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Congrats on graduating Priya! After working in the lab for 3 years on vaccine adjuvants targeting the CD40 signaling pathway in germinal centers, she earned a Distinguished Researcher in Biochemistry award! Now she's off to work on flu vaccines at NIAID’s Vaccine Research Center.
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🚨 new paper alert 🚨 Here, we designed, characterized, and evaluated >100 #malaria vaccines built on our two-component nanoparticle platform! This collaborative project was led by Dr. Mark Langowski and is out now in npj Vaccines:
nature.com
npj Vaccines - Elicitation of liver-stage immunity by nanoparticle immunogens displaying P. falciparum CSP-derived antigens
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There's a new doctor in town, Cameron Criswell defended her PhD thesis last week! 🥳 Congratulations on all your hard work Dr. Criswell!
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Our very own Grace Hendricks gave an excellent talk about her work on mRNA-launched nanoparticles at the Keystone Symposium on Vaccinology in Washington, DC today!
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On Monday, the lab celebrated "Cinco de Cara" in honor of @chao_cara successfully defending her PhD thesis! 🥂 In addition to making MERS vaccines, Cara is a beloved member of the lab who often shares tasty baked goods and infectious laughter. Congratulations, Dr. Chao!
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The IPD is hiring a new Executive Director! This senior leadership role guides institutional strategy, builds research partnerships, drives fundraising, and directs operations at the world’s top center for computational protein design. Apply today!
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Thanks to Gavi, the Vaccine Alliance, more than 1 billion children have been immunized against the world’s deadliest diseases, like tuberculosis and malaria. Now the U.S. government is reportedly planning to end its support for Gavi—support that’s been critical to this progress
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