Christian Thorball
@cthorball
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Translational Genomics @precision_chuv | Cyclist | Father of 3
Lausanne, Switzerland
Joined November 2014
Ethical issues aside, this is a powerful addition to an already strong dataset on Covid-driven brain damage affecting cognition & memory. Given new (re)infections remain common, this work together with the Hampshire et al NEJM paper showing drop in IQ (summarized here
With mild infection in healthy participants who received a #SARSCoV2 challenge there was evidence of persistent cognitive and memory changes at least one year after Covid, compared with uninfected controls https://t.co/HpPLn0peuJ
@ProfHampshire @eClinicalMed
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Looking forward to contributing to this area. Tomorrow at 14:55 in the Madrid auditorium, I'll be discussing our latest work on predicting endocrine toxicities following immunotherapy. #ESMO24
#ESMO24 beautiful discussion by @lab_kok on KN522 OS presentation highlighting impact on young women, importance of QOL and urgent need for Biomarker research. @OncoAlert
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Air purifiers in Finnish daycare reduced children's illnesses by 18% in a carefully controlled study. This implies huge potential for better public health and cost savings from sick leaves, with a simple intervention against airborne infections. https://t.co/7F3KfB9Whw
yle.fi
Tulos haastaa pitkään vallalla olleen käsityksen siitä, että päiväkotien taudit leviäisivät lähinnä pisaroiden ja kosketuksen välityksellä.
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Longitudinal Analysis Over Decades Reveals the Development and Immune Implications of Type I Interferon Autoantibodies in an Aging Population https://t.co/skNvjo73k3
#medRxiv
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1/ Infections in human newborns: severe and frequent, due to age-specific vulnerability. Can this be reconciled with the immense interindividual variability of clinical outcome observed for any neonatal infection? Find out @ Cellular Immunology 👇 https://t.co/XKuBjrPfzV
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Using a genetic approach (Mendelian randomization) cannabis use is not causally associated with risk of coronary artery disease or ischeamic stroke ! well done @roxanedelaharpe @zkutalik
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Our study led by @somijemmacho examines a wide range of factors for predicting recurrent CAD events among pts with CAD. To our surprise, the top predictor was a CAD polygenic risk score. https://t.co/VD03nWwFLq
@ESC_Journals [1/12]
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1/ We are excited to share our report in @JExpMed showing that about 40% of cases of #WestNilevirus (#WNV) encephalitis are due to pre-existing auto-Abs neutralizing type I IFNs, making WNV encephalitis the best understood human infectious disease ( https://t.co/lqug2qZOMT).
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Autoantibodies neutralizing type I IFNs underlie West Nile virus encephalitis in ∼40% of patients https://t.co/8d0W9tmCet Important discovery by @esiborghe & @casanova_lab 👏
rupress.org
Gervais et al. show that auto-Abs neutralizing type I IFNs and pre-existing infection underlie ∼40% of cases of West Nile virus (WNV) encephalitis. Blood a
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@RegeneronDNA new preprint on the sequencing and analysis of 1M WES coming to you soon via a variant allele frequency browser. This goes far beyond @1000genomes (2.5k WGS), @dgmacarthur EXAC (60k WES) or @gnomad_project (125k exomes + 15k WGS) https://t.co/JywzusGaEg
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This is crazy. And just how far above the 1982-2023 sea surface temperature average for the North Atlantic is the year 2023? Data: https://t.co/RxO8s5Y85O
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New: Epigenetic ageing accelerates before antiretroviral therapy and decelerates after viral suppression in people with HIV in Switzerland: a longitudinal study over 17 years by Isabella Schoepf @unibern@UniBasel_en and colleagues https://t.co/z4bNTHTdHF
#OpenAccess
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The @bdsc_UNILCHUV has an open tenure-track faculty position in AI/ML for biomedicine. This is an amazing opportunity to work in a truly interdisciplinary environment, interacting with scientists and clinicians at the @CHUVLausanne and @unil. Please RT. https://t.co/7I88hk7QZs
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Our latest research on the combined impact of genetics and infection on the risk of cardiovascular disease https://t.co/7UVrMRtR5d
@epflSV @CHUVLausanne
actu.epfl.ch
Researchers at EPFL have found that infection with a common bacterium that is linked to periodontal disease, oral cancers, and bad breath may cause a small increase in the risk of cardiovascular...
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Great work by Roxane & Christian on an important issue in clinical practice! @DptMedecineCHUV @CHUVLausanne Combining European and U.S. risk prediction models with polygenic risk scores to refine cardiovascular prevention: the CoLaus|PsyCoLaus Study
academic.oup.com
AbstractAims. A polygenic risk score (PRS) has the potential to improve individual atherosclerotic cardiovascular disease (ASCVD) risk assessment. To deter
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📢📢new pre-print out!!! With @jacquesfellay @precision_chuv we developed a #PRS combining multiple cardiac risk factors to predict the risk of sudden cardiac arrest in patients affected by coronary artery disease
medrxiv.org
Cardiovascular disease (CVD) is a leading health problem and the main cause of death globally. Even when underlying causative factors are known, it is unclear why a cardiovascular condition causes...
A polygenic risk score to predict sudden cardiac arrest in patients with coronary artery disease https://t.co/B3fLJuKzLE
#medRxiv
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Finally online at the Journal of Immunology: A Baseline Cellular Antiviral State Is Maintained by cGAS and Its Most Frequent Naturally Occurring Variant rs610913 by @JuliaKaz3 et al. https://t.co/Pc7Ev7GxlQ 1/4
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Excited to share our @American_Heart Scientific Statement on Polygenic Risk Scores for Cardiovascular Disease! https://t.co/tS840STLmb
@CircAHA
@DrJackOSullivan @sridharan_r_ C. Marquez-Luna @JasmineLuzum @damrauer @euanashley @chrisodmd
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What's the role of host genomics in #COVID19 occurrence and outcomes? Public health implications. Register TODAY to attend our October 6 webinar with @casanova_lab and @jacquesfellay. https://t.co/myNJHmyOvm
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We've learned a lot over the past two years about the genetic architecture of the human response to SARS-CoV-2. Read our review in @ejhg_journal - with @cthorball @ClaireRedin
https://t.co/dbMERTPRt9
nature.com
European Journal of Human Genetics - Host genomics of SARS-CoV-2 infection
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