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Christian Thorball Profile
Christian Thorball

@cthorball

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Following
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Translational Genomics @precision_chuv | Cyclist | Father of 3

Lausanne, Switzerland
Joined November 2014
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@CrabbBrendan
Prof Brendan Crabb
1 year
Ethical issues aside, this is a powerful addition to an already strong dataset on Covid-driven brain damage affecting cognition & memory. Given new (re)infections remain common, this work together with the Hampshire et al NEJM paper showing drop in IQ (summarized here
@EricTopol
Eric Topol
1 year
With mild infection in healthy participants who received a #SARSCoV2 challenge there was evidence of persistent cognitive and memory changes at least one year after Covid, compared with uninfected controls https://t.co/HpPLn0peuJ @ProfHampshire @eClinicalMed
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@cthorball
Christian Thorball
1 year
Looking forward to contributing to this area. Tomorrow at 14:55 in the Madrid auditorium, I'll be discussing our latest work on predicting endocrine toxicities following immunotherapy. #ESMO24
@hoperugo
Hope Rugo
1 year
#ESMO24 beautiful discussion by @lab_kok on KN522 OS presentation highlighting impact on young women, importance of QOL and urgent need for Biomarker research. @OncoAlert
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@tuuliel
Tuuli Lappalainen
1 year
Air purifiers in Finnish daycare reduced children's illnesses by 18% in a carefully controlled study. This implies huge potential for better public health and cost savings from sick leaves, with a simple intervention against airborne infections. https://t.co/7F3KfB9Whw
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yle.fi
Tulos haastaa pitkään vallalla olleen käsityksen siitä, että päiväkotien taudit leviäisivät lähinnä pisaroiden ja kosketuksen välityksellä.
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@medrxivpreprint
medRxiv
2 years
Longitudinal Analysis Over Decades Reveals the Development and Immune Implications of Type I Interferon Autoantibodies in an Aging Population https://t.co/skNvjo73k3 #medRxiv
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@esiborghe
Alessandro Borghesi
2 years
1/ Infections in human newborns: severe and frequent, due to age-specific vulnerability. Can this be reconciled with the immense interindividual variability of clinical outcome observed for any neonatal infection? Find out @ Cellular Immunology 👇 https://t.co/XKuBjrPfzV
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@JulienVaucher
Julien Vaucher
2 years
Using a genetic approach (Mendelian randomization) cannabis use is not causally associated with risk of coronary artery disease or ischeamic stroke ! well done @roxanedelaharpe @zkutalik
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@pnatarajanmd
Pradeep Natarajan
3 years
Our study led by @somijemmacho examines a wide range of factors for predicting recurrent CAD events among pts with CAD. To our surprise, the top predictor was a CAD polygenic risk score. https://t.co/VD03nWwFLq @ESC_Journals [1/12]
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@casanova_lab
Casanova Lab
3 years
1/ We are excited to share our report in @JExpMed showing that about 40% of cases of #WestNilevirus (#WNV) encephalitis are due to pre-existing auto-Abs neutralizing type I IFNs, making WNV encephalitis the best understood human infectious disease ( https://t.co/lqug2qZOMT).
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@cthorball
Christian Thorball
3 years
Autoantibodies neutralizing type I IFNs underlie West Nile virus encephalitis in ∼40% of patients https://t.co/8d0W9tmCet Important discovery by @esiborghe & @casanova_lab 👏
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rupress.org
Gervais et al. show that auto-Abs neutralizing type I IFNs and pre-existing infection underlie ∼40% of cases of West Nile virus (WNV) encephalitis. Blood a
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@coregenomics
James Hadfield
3 years
@RegeneronDNA new preprint on the sequencing and analysis of 1M WES coming to you soon via a variant allele frequency browser. This goes far beyond @1000genomes (2.5k WGS), @dgmacarthur EXAC (60k WES) or @gnomad_project (125k exomes + 15k WGS) https://t.co/JywzusGaEg
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@EliotJacobson
Prof. Eliot Jacobson
3 years
This is crazy. And just how far above the 1982-2023 sea surface temperature average for the North Atlantic is the year 2023? Data: https://t.co/RxO8s5Y85O
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@LancetLongevity
The Lancet Healthy Longevity
3 years
New: Epigenetic ageing accelerates before antiretroviral therapy and decelerates after viral suppression in people with HIV in Switzerland: a longitudinal study over 17 years by Isabella Schoepf @unibern@UniBasel_en and colleagues https://t.co/z4bNTHTdHF #OpenAccess
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@raphg
Raphael Gottardo 📊🧪🖥️
3 years
The @bdsc_UNILCHUV has an open tenure-track faculty position in AI/ML for biomedicine. This is an amazing opportunity to work in a truly interdisciplinary environment, interacting with scientists and clinicians at the @CHUVLausanne and @unil. Please RT. https://t.co/7I88hk7QZs
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@JulienVaucher
Julien Vaucher
3 years
Great work by Roxane & Christian on an important issue in clinical practice! @DptMedecineCHUV @CHUVLausanne Combining European and U.S. risk prediction models with polygenic risk scores to refine cardiovascular prevention: the CoLaus|PsyCoLaus Study
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academic.oup.com
AbstractAims. A polygenic risk score (PRS) has the potential to improve individual atherosclerotic cardiovascular disease (ASCVD) risk assessment. To deter
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@ElePorcu
Eleonora Porcu
4 years
📢📢new pre-print out!!! With @jacquesfellay @precision_chuv we developed a #PRS combining multiple cardiac risk factors to predict the risk of sudden cardiac arrest in patients affected by coronary artery disease
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medrxiv.org
Cardiovascular disease (CVD) is a leading health problem and the main cause of death globally. Even when underlying causative factors are known, it is unclear why a cardiovascular condition causes...
@medrxivpreprint
medRxiv
4 years
A polygenic risk score to predict sudden cardiac arrest in patients with coronary artery disease https://t.co/B3fLJuKzLE #medRxiv
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@GoffinetLab
Christine GOFFINET 🇮🇱
4 years
Finally online at the Journal of Immunology: A Baseline Cellular Antiviral State Is Maintained by cGAS and Its Most Frequent Naturally Occurring Variant rs610913 by @JuliaKaz3 et al. https://t.co/Pc7Ev7GxlQ 1/4
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@pnatarajanmd
Pradeep Natarajan
4 years
Excited to share our @American_Heart Scientific Statement on Polygenic Risk Scores for Cardiovascular Disease! https://t.co/tS840STLmb @CircAHA @DrJackOSullivan @sridharan_r_ C. Marquez-Luna @JasmineLuzum @damrauer @euanashley @chrisodmd
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@CDC_Genomics
CDC Genomics & Precision Health
4 years
What's the role of host genomics in #COVID19 occurrence and outcomes? Public health implications. Register TODAY to attend our October 6 webinar with @casanova_lab and @jacquesfellay. https://t.co/myNJHmyOvm
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@jacquesfellay
Jacques Fellay
4 years
We've learned a lot over the past two years about the genetic architecture of the human response to SARS-CoV-2. Read our review in @ejhg_journal - with @cthorball @ClaireRedin https://t.co/dbMERTPRt9
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nature.com
European Journal of Human Genetics - Host genomics of SARS-CoV-2 infection
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