Eleonora Porcu
@ElePorcu
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Genetic Specialist - Nestlé Institute of Health Science
Losanna, Svizzera
Joined November 2011
Excited to share our work @NatureComms👇#TWMR and #revTWMR quantify bi-directional causal effects between gene expression and complex traits and allow to estimate the large contribution of confounders to the observed trait-expression correlations https://t.co/KDFmTCQ0om
@zkutalik
nature.com
Nature Communications - Identification of gene expression changes between healthy and diseased individuals can reveal mechanistic insights and biomarkers. Here, the authors propose a bi-directional...
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🔔🔔Excited to share my first last-author paper🤩we integrated eQTL, mQTL and GWAS data in MR framework to study how metabolome mediates the effect of transcriptome on complex traits. Importantly, we show how having large molQTL data makes the difference
elifesciences.org
Integrating multi-omics quantitative trait loci and genome-wide association study data into a multivariable Mendelian randomization framework allows to identify metabolite-mediated transcript-to-ph...
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I strongly recommend all early career bioinformaticians to apply for this amazing opportunity!!
~27h left to submit your application. Apply, no matter how likely you think you will get it! It was hard to convince @ElePorcu to do so in 2019, but she doesn't regret it now... ;)
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Excited to share that our paper about DNAm mediation through transcript levels is now published @NatureComms! https://t.co/RNjLcjGGsl Very grateful to all co-authors @CAuwerx @kaidolepik @ElePorcu @zkutalik for their precious contribution! #omics #GWAS #MendelianRandomization
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I will be always grateful for the opportunity I had to do my postdoc in @zkutalik lab! Amazing supervisor, great colleagues, exciting science…you cannot ask more🤩 Strongly recommended!!
Post-doc position open in my group. Are you a curious, motivated scientist with good stats background? Would you like to develop creative causal inference methods next to Lake Geneva and surrounded by these mountains? Apply by 30 September! More details: https://t.co/jRNoiEklSd
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A great team effort with @AnniqueC Antoine Weihs @kaidolepik BIOS Consortium @iTomRichardson Uwe Völker @FredSantoni @AlexanderTeumer @LudeFranke Alexandre Reymond @zkutalik
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🔔Finally published @GenomeMedicine!! Read out how we showed that the sex-specific heritability is not detectably mediated by sex-specific gene expression regulation in whole blood https://t.co/055b7B0yi0
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A polygenic risk score to predict sudden cardiac arrest in patients with coronary artery disease https://t.co/wJXFLoluMu
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📢📢new pre-print out!!! With @jacquesfellay @precision_chuv we developed a #PRS combining multiple cardiac risk factors to predict the risk of sudden cardiac arrest in patients affected by coronary artery disease
medrxiv.org
Cardiovascular disease (CVD) is a leading health problem and the main cause of death globally. Even when underlying causative factors are known, it is unclear why a cardiovascular condition causes...
A polygenic risk score to predict sudden cardiac arrest in patients with coronary artery disease https://t.co/B3fLJuKzLE
#medRxiv
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Waiting forward to discussing with you about PRS in cardiovascular diseases! With @jacquesfellay we propose a metaPRS to predict the risk of sudden cardiac arrest in CAD patients! Come to discuss with me today at 1pm - poster P25.001.A #eshg2022
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Super happy to join the #ESHG2022 in Vienna!! We are back with in person conferences and it’s really exciting!! @eshgsociety
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🔔New pre-print out!!! With @CAuwerx @smarie_smarie Alexandre Reymond and @zkutalik we combined eQTL, mQTL and GWAS data in a multi-omics Mendelian Randomization approach to identify metabolites mediating transcript-trait associations. https://t.co/1L5f7INDuS
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Come work with us on translational genomics: bioinformatician & data scientist positions at @CHUVLausanne precision medicine unit @precision_chuv. Enthusiasm, skills, and some French required... https://t.co/IMDJbbmuuc
https://t.co/sYKcrSXSwT
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🤩🤩Amazing work done by @jenny_sjaarda and @zkutalik using MR to investigate couple phenotypic similarity and distinguish causal and confounding effects 👇🏻
We're happy to share our work on applying Mendelian randomisation to dissect causes and confounders of assortative mating in the UK Biobank. https://t.co/3gSENeTF7H
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New! @CAuwerx et al. explore the impact of CNVs on complex human traits @unil
https://t.co/HarNjHfBmj
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Excited to have my 1st first author paper out in @AJHGNews! 🤩 We explored the role of individual #CNVs and their burden in complex traits using @uk_biobank and @ESTbiobank data. Summary of findings 👉🏻 https://t.co/gCwzpCSmGn. Full text in #OpenAccess 👉🏻 https://t.co/EVuW9gYz8k.
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Our new study on parent-of-origin (PofO) effects in the UK Biobank is now on @biorxivpreprint ! Come and read how we inferred the PofO for more than 26k individuals and how this allowed us to discover 101 PofO effects. https://t.co/H2VQlp9MD9
biorxiv.org
Identical genetic variations can have different phenotypic effects depending on their parent of origin (PofO). Yet, studies focussing on PofO effects have been largely limited in terms of sample size...
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I could not recommend it more strongly! Just left the group and I'd apply again 1,000 times to join @zkutalik group! Amazing supervisor, amazing group, amazing environment. You have all the ingredients to do great science! Don't miss this opportunity!
Do not forget to apply by 15 October! In case you are interested to learn how complex trait genetics can be combined with molecular QTLs to infer causal disease networks, our group (and the Swiss mountains) may be a good place for you...😉
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We followed the classical cascade of methylation -> Gene expression -> protein levels -> complex traits and found several surprises... Detective work spearheaded by @smarie_smarie & crucial support from @CAuwerx @ElePorcu
https://t.co/DMof3OJvyw
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