MarleenKokLab Profile
MarleenKokLab

@lab_kok

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medical oncologist, breast cancer immunotherapy investigator, mother, PI and associate prof at NKI, happy in Amsterdam

Amsterdam
Joined June 2020
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@lab_kok
MarleenKokLab
1 year
Excited to present 🎤 first data #SABCS24 from TONIC2. Follow-up from https://t.co/07YbYYMKQ7. Are immune induction with dox or cisplatin indeed benefiting pts? @VeerleGeurts at P1-7-30 and new data on acquired resist🔬 to aPD1 at PS17-09 @NKI_nl @OncoAlert @NatureMedicine
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nature.com
Nature Medicine - A pick-the-winner clinical trial design in patients with metastatic triple-negative breast cancer shows that immune induction with doxorubicin or cisplatin may improve clinical...
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@lab_kok
MarleenKokLab
1 year
Recent Nature paper on phase of menstrual cycle at start of breast cancer chemo suggests that this can affect chemo-sensitivity. More research needed on how this can result in cycle-driven-chemo-start. 💊💉Congrats ⁦@vanRheenen_Lab⁩ ⁦@NKI_nl
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nature.com
Nature - In three mouse models of breast cancer, we show reduced responses to neoadjuvant chemotherapy when treatment is initiated during the dioestrus stage, when compared with initiation during...
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@lab_kok
MarleenKokLab
1 year
This is well-deserved! Congrats @deVisserKarin 🥳🥳. She was one of the first scientists recognizing the importance of immune cells in breast tumors. Thanks to key leaders like Karin we now start doing trials specific for BC with high TILs #OPTImal study @NKI_nl @TILsWorkGroup
@NKI_nl
The Netherlands Cancer Institute
1 year
🎉 Congratulations to @deVisserKarin on receiving the prestigious 2025 Pezcoller-Marina Larcher Fogazzaro-EACR Women in Cancer Research Award! Karin’s groundbreaking work is internationally recognized ➡️ https://t.co/9JQvtSQtgR
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@lab_kok
MarleenKokLab
1 year
Fantastic PhD program at amazing institution @NKI_nl 👇
@NKI_nl
The Netherlands Cancer Institute
1 year
📢 Applications for the NKI PhD program open from Jan 1 - Feb 28. Join our international research community in Amsterdam, working in cancer biology, AI research & life sciences with leading scientists and top facilities #PhD #CancerResearch More info: https://t.co/Ln7xs1zphE
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@MarjoleinMoor
Marjolein Moorman
1 year
Mensen die naar ons land vluchten voor hun leven, voor de toorn van kwaadaardige regimes die we bestrijden bijvoorbeeld, wil de coalitie vanaf nu elke kans ontnemen nog iets van hun leven te maken…. Er is inderdaad een ernstige crisis gaande in ons land. Een morele crisis.
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@lab_kok
MarleenKokLab
1 year
Stellar line up of speakers and spot on discussions and clinical cases! In the beautiful town of Padua🇮🇹 #AIBCC24 with @MOliveira_MD @vitti10 @prat_aleix @hoperugo and many others!
@angela_toss
Angela Toss
1 year
One of the unmissable meeting of the year, over the past 20 years! #AIBCC24 Now on stage @lab_kok on Immune system and #BreastCancer @valeguarneri @prat_aleix @vitti10 @GaiaGriguolo @FedeMiglietta
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@lab_kok
MarleenKokLab
1 year
On my way to one of the best conferences on translational cancer research! #MAP24 🚆🚆💚💚
@myESMO
ESMO - Eur. Oncology
1 year
📣 Register now for MAP 2024, 16-18 Oct, London. Join us for sessions on immune cells in SCLC, anti-tumour immunogenicity, endocrine resistance in breast cancer, FAT1 and the Hippo pathway, and more. #MAP2024 🔗 https://t.co/wIE0jEGohK
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@lab_kok
MarleenKokLab
1 year
This will be amazing session #SABCS24 with stellar speakers and immune biomarkers inc TILs making their way to the clinic!
@SABCSSanAntonio
SABCS
1 year
State of the Art: The Winding Road of Immune Biomarkers in Early Breast Cancer— Roberto Salgado, Justin Balko, and Priyanka Sharma will address this topic in this special session at #SABCS24 (December 10-13). Learn more: https://t.co/UUzCz68ehg @BalkoLab @psharmalab
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@NKI_nl
The Netherlands Cancer Institute
1 year
👀 We're looking for a junior group leader! Join our innovative, curiosity-driven institute in a collaborative, international environment. Full freedom to pursue your research, competitive salary & relocation support. 📅 Apply by Dec 1 Info & application: https://t.co/my1GSyAsQy
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@lab_kok
MarleenKokLab
1 year
Thanks @ACIR_org for putting our work on neoadjuvant immunotherapy for TNBC in the spotlight @riannerolfes @Manon_deGraaf @LambrechtsDlab @NatureMedicine
@ACIR_org
ACIR
1 year
In an adaptive, window-of-opportunity phase II neoadjuvant trial in early breast cancer, Nederlof and Isaeva et al. report that 4 weeks of anti-PD-1 or anti-PD-1 + anti-CTLA-4 showed immune activation in 53% and 60% of [...] https://t.co/fVB3xdciH9  @NKI_nl  @lab_kok
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@CCR_AACR
Clinical Cancer Research
1 year
Clinical Cancer Research is seeking a new Editor-in-Chief! Apply by September 30, 2024. Find out more: https://t.co/osxa1jTKgs
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@JuliaFoldiMD
Julia Foldi, MD PhD
1 year
Had a fantastic meeting at the #ILCsymposium in beautiful Leuven, Belgium organized by @ChristineDesme2 and her team! Lots to think about, and lot more progress that needs to be made! @oesterreichs @Adrianvlee
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@lab_kok
MarleenKokLab
1 year
Best break-out session ever on TME in lobular BC! Important especially since pts with ILC are often excluded from immunotherapy trials. Thanks for terrific organisation and location @ChristineDesme2 @elbcc #ilcsymposium @oesterreichs
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@lab_kok
MarleenKokLab
1 year
A very impactful #ESMO24. Thanks @RebeccaDSing and great ESMO staff @myESMO @KKronig! Minor note: @NatureMedicine had even more concomitant papers of which 2 from @NKI_nl
@myESMO
ESMO - Eur. Oncology
1 year
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@lab_kok
MarleenKokLab
1 year
#ceasefire now! ❤️‍🩹
@LeilaAkkari1
Leila Akkari
1 year
A rare, non scientific post on my side…I usually don’t use this platform for it, but I am motivated by others to. I am half Lebanese, all my father’s family is there, some in the south. My heart breaks for my country and for Gaza, as a Lebanese and a mother. #Ceasefire.
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@lab_kok
MarleenKokLab
1 year
Very excited that we see a 33% pCR rate with only 6 weeks of immunotherapy without chemo in TIL high TNBC. A lay version of our story👇. @NKI_nl @TILsWorkGroup @NatureMedicine
@NKI_nl
The Netherlands Cancer Institute
1 year
Immunotherapy as a treatment for triple-negative breast cancer appears to be effective even without chemotherapy, according to NKI research. This could prevent overtreatment and side effects associated with chemotherapy ➡️ https://t.co/Zx6NradVYx
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@lab_kok
MarleenKokLab
1 year
👇Wij zoeken een ervaren, enthousiaste, pro-actieve en flexibele Project Manager voor een groot, internationaal onderzoek om biomarker (TILs) naar de kliniek te brengen.
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@dr_yakupergun
Yakup Ergün
1 year
#ESMO24 Neoadjuvant nivolumab/relatlimab or nivolumab/ipilimumab in TNBC with high TILs: BELLINI trial 🔍stage I-II, node negative, TILs ≥50%, 30 pts pCR Nivo+IPI➡️33% Nivo+RELA➡️47% 💥Remarkable efficacy of chemotherapy-free immunotherapy for immunogenic TNBC
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@PTarantinoMD
Paolo Tarantino
1 year
Promising results with neoadjuvant nivo/relatlimab (LAG3 mAb) for mostly cT1c TNBC with high TILs: 47% pCR rate, 73% MPR. Immune toxicities remain an issue, with a case of diabetes mellitus. Terrific work from the team of @lab_kok — concomitant @NatureMedicine publication
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@lab_kok
MarleenKokLab
1 year
A simultaneous publication of our BELLINI data @NKI_nl presented today as oral abstract on exploring nivo/ipi in TNBC without chemo. Thanks #ESMO24 and @NatureMedicine!
@NatureMedicine
Nature Medicine
1 year
Out now for #ESMO24! In #BELLINI, pts with early-stage #TNBC received neoadjuvant #Nivolumab w/ or w/o #Ipilimumab, leading to ctDNA clearance & promising clinical response rates, esp. in preselected pts w/ high TIL levels @lab_kok @NKI_nl https://t.co/na6yMnITOY
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