LLMs are ideal models for molecular biology. Here is my new essay reviewing some recent advances and looking to the future. @manoliskellis @lindaavey @anshulkundaje @BoWang87 @StevenSalzberg1 @illumina @chrmanning @slavov_n https://t.co/XXne1jVkWU

Introducing PrimateAI-3D, a significant step forward in our use of deep learning to identify genetic mutations most likely to cause disease. Learn more about the groundbreaking research behind the updated algorithm, published today in @ScienceMagazine. https://t.co/OlFfHqyNfs

Interesting study of UK Biobank exomes for common traits. In aggregate, rare variants still explain much less variance than common PRS (note scale is corr), but can already better identify phenotypic extremes (top 0.1%). https://t.co/4rRfRwp5c0

LEUKOCYTE: a complete musical overview of the human immune system hope @bts_bighit don't mind :)

Groundbreaking research by Mo Ameen and Laksshman Sundaram in @Cell highlighting AI to diagnose non-coding de novo mutations in congenital heart disorders, with Anshul Kundaje, Will Greenleaf, Thomas Quartermous, Kevin Wang, Ioannis Karakikes at @Stanford:

Our's and other bioinformatics data science groups at Illumina Singapore are rapidly expanding in the coming months. If the prospect of using *big* data to make fundamental and impactful discoveries in genome biology excites you, please reach out to me.

We will develop and use best-in-class AI methods (including deep learning) to better understand the biological and clinical impact of human genetic variation, with a particular focus on Asian genomes in Singapore.

A big-ish announcement: I've just started a new position @Illumina, and I'm currently spinning up the Singapore branch of the Illumina AI lab.

On this 5 year anniversary of the Berger lab, I’m so excited to share our latest work: https://t.co/7x8vt5TEjv Congratulations to authors @pcrparrish @jdthomaslab @a_gabel2 @skamlapurkar30 @bradleybio! Our goal was to identify synthetic lethal human paralog pairs. 1/

With the new academic year starting, and many people beginning fresh as graduate students, post-docs, or junior faculty, I have been thinking a lot about the core philosophies that govern my own perspectives on science. So I thought I would share. Welcome to The Tao of Cheese

I am SO thrilled to share the first pub led by my independent lab, online at Nature Communications: https://t.co/siWdhmzzyp - Huge congratulations to @athea_vichas, Amanda Riley, and @NNkinsi who led this work! Our goal was to identify new therapies for RIT1-mut lung cancer. 1/

Want to further your computational training in one of the most tech-friendly (and beautiful) cities in the world? Come join me @csi_singapore! Multiple open post-doc positions in cancer genomics and digital health https://t.co/ldtjVjnREx Please RT!

What will it be like to live with endemic COVID? Our future with the virus will depend on the strength of our immune memories. I wrote about what we know and what we still have to learn about COVID immunity for @NewYorker: https://t.co/9IV2dZWY76

What does the mysterious phenomena of 2-cell like cells, ZGA embryos, and the most common human muscular dystrophy (FSHD) have in common? They're all in this paper! Buckle up, kiddos, this one was a wild ride: https://t.co/Tp4cUeJGoL @NatureGenet /1

CSI Career Accelerator Postdoctoral Fellowship invites outstanding early-stage postdoctoral fellow applicants. An opportunity to develop independent research program, work with exceptional researchers and gain access to world-class facilities. Apply now! https://t.co/N07SE6nFAW

In a lab study, Fred Hutch's @bradleybio and collaborators @sloan_kettering showed that drugs that temporarily alter mRNA in tumor cells make them more susceptible checkpoint blockade #immunotherapies such as #pembrolizumab, or Keytruda.

Excited to share our collaboration w/ @bradleybio demonstrating that pharmacologic modulation of splicing induces immunogenic neoantigens and augments response to checkpoint blockade. Jointly led by @SXLuLab, @ejdeneef, @jdthomaslab. Out today in @Cell: https://t.co/kKWVNjnv9C

I'm excited to share our finding that RNA splicing modulatory drugs trigger anti-cancer immune activity and enhance the response to immune checkpoint blockade. Amazing collaboration with @AbdelWahablab, just out in @CellCellPress https://t.co/ZbOeUNzEyH.

CSI Career Accelerator Postdoctoral Fellowship invites outstanding early-stage postdoctoral fellow applicants. An opportunity to develop independent research program, work with exceptional researchers and gain access to world-class facilities. Apply now! https://t.co/N07SE6nFAW

FACULTY POSITIONS: In any area of cancer research, but particularly encourage applicants with interests in the #ComputationalBiology analysis of #CancerEvolution, #CancerImmunology & #immunotherapy, & #epithelial #cancerbiology https://t.co/l0ZqrBeZTK #tenuretrackjobs Please RT!