Emma De Neef
@ejdeneef
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grad student @uwgenome @fredhutch, she/her
Joined May 2021
It was so great to work with and learn from all of you, and I'm really excited to see where this goes next!
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1/ Premise is to make antigenically ‘cold’ tumors ‘hot’ by pharmacologic RNA splicing modulation w drugs, e.g. RBM39 degraders https://t.co/m2D3yyRAPo & PRMT inhibitors https://t.co/ugf6q0NthW, w goal of generating novel mRNAs that are translated to antigenic proteins.
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From @AbdelWahablab:
Excited to share our collaboration w/ @bradleybio demonstrating that pharmacologic modulation of splicing induces immunogenic neoantigens and augments response to checkpoint blockade. Jointly led by @SXLuLab, @ejdeneef, @jdthomaslab. Out today in @Cell: https://t.co/kKWVNjnv9C
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It was amazing to get to work with so many talented people on this project, and I'm very excited to see the paper out today! Check out these great explainers, starting with @bradleybio:
I'm excited to share our finding that RNA splicing modulatory drugs trigger anti-cancer immune activity and enhance the response to immune checkpoint blockade. Amazing collaboration with @AbdelWahablab, just out in @CellCellPress
https://t.co/ZbOeUNzEyH.
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