Changhao He
@changhaohe42
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We don't know what we don't know. HHMI Postdoc researcher @UCSF @LSRFdtn | PhD @WeillCornell
San Francisco, CA
Joined May 2013
RT @PossuHuangLab: 1/ In two back-to-back papers, we present our de novo TRACeR platform for targeting MHC-I and MHC-II antigens. TRACeR f….
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RT @aliceyting: Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigen….
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RT @rborza_: AlphaFold can predict protein, DNA, or RNA complexes. BUT is it easy to determine the reliable interactions?🤔. ➡️ AlphaBridge….
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RT @SaligramaLab: #Fresh off the #press Talk about #TCR #crossreactivity being #important Neoself-antigens are the primary target for autor….
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RT @Xinru71: Now online: We created de novo insulin receptor agonists using computational protein design! @EunheeChoi12 @XiaochenB @Preetha….
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RT @NobelPrize: This year’s medicine laureates Victor Ambros and Gary Ruvkun studied a relatively unassuming 1 mm long roundworm, C. elegan….
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RT @ScienceMagazine: The central dogma of molecular biology states that genetic information flows from DNA and RNA to protein, with reverse….
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RT @ColumbiaMed: Columbia welcomes CAR-T pioneer Michel Sadelain, MD, PhD, as the inaugural director of the new Columbia Initiative for Cel….
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"transceptor" comprising both a transporter domain and a GPCR domain - I am confused and amazed at the same time.
Excited to share our preprint on the structure of human lysosomal transceptor GPR155, revealing its ability to transport auxin. Fantastic collaboration with Shikha Singh @ShikhaS4858 and a great achievement by a Ph.D. student Mansi Sharma @Mansi_Sharma9.
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RT @jsoriamd: Bispecific antibodies (bsAbs) allow therapeutic applications that cannot be achieved using conventional antibodies. There are….
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RT @alessiociulli: Thrilled to share that, together with my colleagues @UoDCeTPD and collaborators @Boehringer, we report @ScienceMagazine….
science.org
Mutations in the Kirsten rat sarcoma viral oncogene homolog (KRAS) protein are highly prevalent in cancer. However, small-molecule concepts that address oncogenic KRAS alleles remain elusive beyond...
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RT @LaskerFDN: Congratulations to Zhijian “James” Chen, 2024 #LaskerAward winner! – “for the discovery of the cGAS enzyme that senses forei….
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RT @MitoPsychoBio: There are many mitochondrial functions and many ways to be "dysfunctional". What we call "dysfunction" often is an overl….
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RT @StevenMBanik: Excited our final version of @tineisadora's work on targeted protein relocalization is out today @nature! Molecular contr….
nature.com
Nature - Targeted protein relocalization using shuttle proteins with potent ligands amenable to incorporation into targeted relocalization activating molecules could be used to regulate cellular...
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this is something I wish I could work on.
Next level reconstitution: Combining the malate decarboxylation pathway with transporters (GltP, LacY) in liposomes, Miyer and Zaid generated stable proton and electrical potential gradients and accumulation of glutamate and lactose over periods of hours.
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RT @DdelAlamo: I take back what I said, the latest Baker lab paper achieves picomolar affinity with two rounds of design, 96 sequences expr….
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RT @LabWaggoner: "stay curious and excited about science, especially about what’s happening outside your field. You never know where your n….
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RT @LabWaggoner: Reactivation of EBV is a possible factor that causes MHC class II molecules to present neoself-antigens by decreasing the….
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