Excited to share @Nature: How does naloxone (Narcan) stop an opioid overdose? We determined the first GDP-bound μ-opioid receptor–G protein (wt) structures and found naloxone traps a novel "latent” state, preventing GDP release and G protein activation. 🧵 https://t.co/E2fZXw2Pom

Happy to share our new review of kainate receptor structure and gating. @shantigangwar @MariaKarela3 @LauraYen42 https://t.co/Lo9CKLmxS4

How magnesium balance goes wrong Magnesium is a key electrolyte for nerve signaling, muscle contraction, and heart rhythm. Because it regulates over 300 enzymatic reactions, both low and high magnesium levels can disrupt nearly every system in the body. This diagram shows how

DRILS-ARUMDA/TIFR joint #postdoctoral position Exciting opportunity to contribute to biomedical research aligned with national missions Complex phenotypes, malnutrition, NCDs, aging Please RT #academic #DataScience #multiomics #metabolomics @IndiaBioscience @biopatrika

Genome maintenance by telomerase is a fundamental process in nearly all eukaryotes. But where does it come from? Today, we report the discovery of telomerase homologs in a family of antiviral RTs, revealing an unexpected evolutionary origin in bacteria. https://t.co/OlU6HOLQfK

As ever, beautiful #cryoEM work from the lab of Hong Zhou with field-defining insights using #cryoET: “Kiss-shrink-run” unifies mechanisms for synaptic vesicle exocytosis and hyperfast recycling | Science https://t.co/7mQdMIRHgU

Our immune system is an evolutionary masterpiece. Every day it protects us from the thousands of different viruses, bacteria and other microbes that attempt to invade our bodies. Without a functioning immune system, we would not survive. One of the immune system’s marvels is its

Today, we report Germinal, a method for efficient de novo antibody design, with @santimillef and @SynBioGaoLab. Germinal achieves success rates of 4-22% across diverse epitopes. We make the work fully open, without doing lame things like posting a preprint without methods. 🧵

New preprint - basically we noticed that by applying ab initio (SDG) at high res in CS, using a very small step size, we could crack some small proteins we hadn't been able to solve before. Read the preprint or head over to bluesky for a longer thread! https://t.co/aTe4bNxmuf

Cryo-EM structure of endogenous Plasmodium falciparum Pfs230 and Pfs48/45 fertilization complex | Science

Structures of kainate receptor channel GluK2 in the apo closed and open conducting states, both with 2-fold symmetrical LBD layer. To open the channel, we used agonist kainate and positive allosteric modulator BPAM but no Concanavalin A! @shantigangwar https://t.co/r4RWqXAxCn

SLC45A4 is a pain gene encoding a neuronal polyamine transporter | Nature

CryoEM structure of the human uromodulin filaments (PDB code: 9NU3) #scivis #molecularart @dzine_ai @proteinimaging https://t.co/s0uiKVNCm9

Disulfide-based dimerization of modified nanobody scaffolds enables higher-order assembly for high-resolution cryo-EM structure determination that is widely applicable to small protein targets https://t.co/33oNxiTARB

Our #CryoET story on how a top antimalarial drug candidate perturbs the native malarial translation machinery is out @NatureSMB🥳 https://t.co/5SaPnwQ4zf Massive team effort led by @leonie_anton @mehsehret @Wenjing_Cheng_ in collaboration with @DziekanJerzy @CowmanAlan #teamtomo

Wow! A pancreas–hippocampus feedback mechanism regulates circadian changes in depression-related behaviors https://t.co/zqegMvJCqw

High throughput cryo-EM provides structural understanding for modulators of the lysosomal ion channel TRPML1

Secondary chelation through shared water provides ion selectivity in bacterial sodium channels

Mechanism of substrate recognition and release of human SGLT2 | Nature Communications

Martínez-Lázaro, Bartolomé-Martín, Giraldez et al @UL show that two GRIN2B variants disrupt nanoscale coupling btwn NMDA receptors and BK channels, revealing nanodomain dysfunction as a potential mechanism contributing to GRIN2B-associated pathophysiology https://t.co/XogPNcTmcy