This is insane. New AI model from Samsung, 10,000x smaller than DeepSeek and Gemini 2.5 Pro just beat them on ARC-AGI 1 and 2 Samsung’s Tiny Recursive Model (TRM) is about 10,000x smaller than typical LLMs yet smarter because it thinks recursively instead of just predicting

I am thrilled to release ProteinDJ: a high-performance and modular protein design pipeline. Our open-source workflow incorporates #RFdiffusion, #ProteinMPNN, #FAMPNN, #AlphaFold2 and #Boltz-2. It is a fast, free, and fun way to design proteins (1/5) https://t.co/IOlC0JKvOL

Excited to share Caliby 🐈, our new model for structure-conditioned sequence design! Caliby is a Potts model-based sequence design method that can condition on structural ensembles. We use this to average out non-structural signal (e.g. evolutionary bias) learned by models 🧵1/N

AlphaFoldDB updated, now includes the MSAs 🥳

Viral AlphaFold Database dropped! NCBI RefSeq → 647,000 viral protein seqs MMseqs2 → ~117,000 clusters AlphaFold2 → 26,962 monomers AlphaFold-Multimer → 26,754 homodimers Foldseek → 12,894 structural clusters Enjoy.

Zincore, an atypical coregulator, binds zinc finger transcription factors to control gene expression @ScienceMagazine @NijmanSebastian @ThijnBrummel #Perrakis @Daaninthelab https://t.co/0sb9BkupzI https://t.co/uguvFwVLvU

👏 Amazing work! I think there is still much to learn about SRBD1, not only in mitosis but in other possible functions it may have👀 Full article:

👏 Amazing work! I think there is still much to learn about SRBD1, not only in mitosis but in other possible functions it may have👀 Full article:

🚨 New strategy against colorectal cancer! Dual GSK-3 & BCL-XL inhibition kills APC-mutant cells in organoid models, tipping the balance towards healthy cells—a promising way to halt early tumor growth 💪 ➡️Read more:

👀 Just updated my Google Scholar and... can’t believe one of my papers reached 100 citations! 🚀 💪🏼 It might not seem like much, but as a PhD, it feels like a big achievement. ❤️ To all fellow PhDs, keep going and celebrate every milestone!🔁 Read it: https://t.co/V6sS6kiqln

🚀 My first Cryo-EM structures are OUT on the PDB! 🎉Super excited about this milestone as PhD, it’s been a long journey, and I’m grateful to finally have these as my first Cryo-EM structures! 🙌 🔁Thank you for sharing! ❤️ Read @Daaninthelab et. al.: https://t.co/rHrHTDki4S

Really glad to contribute to this work from the @TassosPerrakis group at @NKI_nl, in which we try to understand how the Autotaxin "tunnel" is crucial for ATX/LPA signaling and dictates specific cellular response, published in @CellChemBiol. Check it out 👇 https://t.co/d0tJVBn3FY

📢 Ready for this? A new way to think about Gene Regulation! 🚨 A new coregulator complex, Zincore, acts as a "MOLECULAR GRIP", stabilizing TFs at DNA binding sites across the genome!🧬 💪 Proud to be part of this work led by @Daaninthelab Read more: https://t.co/RbdMv4W0VG

📢 Make your work FASTER and EASIER! Use AlphaBridge to analyze your AlphaFold results and receive a clear, easy-to-understand output—even for non-experts. ➡️ Let AlphaBridge help you accelerate your work! 🌐Try it: https://t.co/w4fqySX3Zx 👀Read more: https://t.co/wfEK74sSpo

AlphaFold can predict protein, DNA, or RNA complexes.. BUT is it easy to determine the reliable interactions?🤔 ➡️ AlphaBridge will identify the most confident interactions, making your analysis easier! 🌐Try it here: https://t.co/VoUvfdDruD 👀Read more: https://t.co/wfEK74sSpo

🚀 Excited about our pre-print: AlphaBridge: A User-Friendly Tool for Interpreting Protein Predictions Whether you're an expert or just new to the field of Protein Prediction, AlphaBridge is the way to go! 🔁Try it and share your thoughts! 📜 Article: https://t.co/cH0BL8OxpX

🚨New Article Out!! 📢 In our latest work, we propose a Three-Point Lock binding mode for ATX inhibitors 🔒 🚀 This approach may represent the final piece in the puzzle of known binding mode types — and could have therapeutic relevance Read more here: https://t.co/afJQUJWTEt

📢 Excited to announce that our Opinion paper on GPI-anchored proteins is now Published! 🎉 👀 If you're working in this field, be sure to check out our paper — we've highlighted some truly outstanding questions on the topic! ⚠️ https://t.co/tPGN98QYZr

📢 Make your work FASTER and EASIER! Use AlphaBridge to analyze your AlphaFold results and receive a clear, easy-to-understand output—even for non-experts. ➡️ Let AlphaBridge help you accelerate your work! 🌐Try it: https://t.co/w4fqySX3Zx 👀Read more: https://t.co/wfEK74sSpo

Working on a figure for my seminar today made me realize just how many design styles you can create with ChimeraX! 🤔Is everyone familiar with the full range of styles in ChimeraX? ‼️ By the way, the toughest choice (and always will be) is picking the right colors!