Membrane Enzymology
@MembraneEnzymo1
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Research Group ⚗️🧪🧫🧬🔬
Groningen, Nederland
Joined January 2019
If you are interested in a joined effort towards building a synthetic cell (including -of course- membrane transporters), have a look at this post:
nature.com
12 PhD/Post doc positions for the design and engineering of synthetic cells
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Next level reconstitution: Combining the malate decarboxylation pathway with transporters (GltP, LacY) in liposomes, Miyer and Zaid generated stable proton and electrical potential gradients and accumulation of glutamate and lactose over periods of hours.
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It took some time, but Anna’s @amborowska beautiful work on the exchange mechanism of ASCT2 is now out. Together with twitterless Gabriella and @CPaulino @alisa_garaeva @rheinbergerj @CG_Martini .
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Congratulations Jose! Not only for the paper (, but also for you successful defence of your thesis yesterday.
I am excited to announce the publication of the main project of my PhD and my first publication as a first author. You can find the abstract of the research here: . If you are interested in vitamin B12 research, DM me for the full article.
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Bacterial S-components have crossed the border between transporters and receptors Congratulations to Michele on finding this unexpected "transceptor" link
Very proud to get this work out on @CommsBio, from my postdoc in @MembraneEnzymo1 . A "Behind the paper" summing up the ins and outs of the bacterial "transceptor" is also available here
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RT @IvanMasl0v: Single-molecule optical tweezers reveal salt dependence of the interdomain interactions in a membrane transporter OpuA in n….
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Back from the GRC Ligand Recognition and Molecular Gating; sadly the chair Kaspar Locher could not be present but stand-ins Crina @CrinaNimigean and Edmund @Mitocarriers saved the conference, together with the GRS chairs Anna and Franziska @amborowska.@fmheydenreich. Thanks!
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Also have a look at the constructive (and flattering) reviewer comments. If only the peer reviews were always like this. .
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Mark's tour-de-force work shows that the ABC transporter BacA from Mycobacterium mediates unprecedented bi-directional transport of cobalamin. Great team effort with Solène and @chancie_t (Chancie)
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In very good tradition of celebrating beautiful data, the image has been stuck on my door for some time now!
🎅"Cryo-EM structure of Santa’s hat" by Chancievan Thangaratnarajah, @univgroningen . 🦠Belonging to the ECF transporter family, this hat mediates the uptake of essential micronutrients like vitamins and transition metals into the cell!. 🔬Talos Arctica @thermosciEMSpec
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Congratulations to Ivan!.
I am thrilled to be awarded a Marie Sklodowska-Curie Postdoctoral Fellowship #MSCA to study the dynamic organization of bacterial membranes at the @MembraneEnzymo1 @ResearchGbb @univgroningen! Great thanks to @MSCActions!.
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RT @LenOvosch: What are the limiting factors of protein diffusion in bacteria periplasm and what influences it? .We used single-protein dis….
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ECF transporters never fail to surprise. Michele found a new transceptor case: Happy holiday break!
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Anna will be chairing the 2024 #Ligand Recognition and Molecular Gating GRS in Ventura, CA. Join her there, it will be amazing!.
Interested in stories about structure, mechanism, and ligand modulation of #receptors, #ionchannels and #transporters? Join us at the 2024 #Ligand Recognition and Molecular Gating GRS in Ventura, CA🇺🇸. Apply before Dec 17 for the talk and spread the word!
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Solène is an artist, not only for cake decoration, but also in the lab!.
Also also, cake made by Solène Lefebvre @MembraneEnzymo1 for mine and @chancie_t farewell party 😋 here is SLC9C1 and the "weird and wonderful" ECF transporter! If you missed this story check it out now 👇.
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Congratulations to Valeria and the rest of the team! It still feels like a piece of work that we can all be proud of in Groningen, where you spend so many hours optimizing expression, purification and data processing. even though all of you have moved on - sadly (!).
I was often asked what I was working on in @CPaulino_ group. Well, here it is! 🥁🥳 What a fascinating combination of ion channel and secondary active transporter domains in one protein! Great teamwork with @MartinPeter91.@rheinbergerj.
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RT @chancie_t: Maps and models for our work have been released by @PDBeurope.16120/8BMP - ECF-FolT2 + ADP/ATP (MSP2N2).16121/8BMQ - ECF-Fol….
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Good things that come to an end… Eleonora did a fantastic job in defending her thesis “Recycling to grow”! Laura and Sebas are writing up their breakthrough work from their postdoctoral fellowships @oLifeFP, and sadly will be leaving us. We will miss you so much!
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Exciting unpublished work already got recognition: Miyer won the poster prize at Mark presented at the GRC on Mechanisms of membrane transport. Anna @amborowska will be chairing next year’s GRC on ligand recognition
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Something that looks "so last decade”: We studied a mutation that causes disease in the human glutamate transporter EAAT1. in a prokaryotic homologue. We did not have the funds to work on the human proteins themselves…
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