Choi Lab
@EunheeChoi12
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Cell biologist, Studying the role of cell division regulators in insulin signaling
New York, NY
Joined October 2019
Happy to share our recent work with @Xinru71 #BakerLab @XiaochenBai #insulin.- Computational design yielded super agonists, partial agonists, and antagonists of insulin receptor. - Designed agonists tune IR signaling by modulating conformational dynamics of activated IR.
Now online: We created de novo insulin receptor agonists using computational protein design! @EunheeChoi12 @XiaochenB @PreethamVi @UWproteindesign #BakerLab
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RT @FitzpatrickLab: Over 20 years ago, Zuker et al. discovered the mammalian sweet taste receptors. Now, an exciting collaboration between….
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RT @davidrliu: Last night I was honored to receive the 2025 #BreakthroughPrize in the Life Sciences, reflecting the efforts of many student….
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RT @NobelPrize: ”There are a lot of cases where the really important, critical suggestions come because one person on one project suggests….
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Excited to announce our latest review on #insulin -IGF receptor signaling! @NatRevMCB .
nature.com
Nature Reviews Molecular Cell Biology - Insulin and insulin-like growth factor (IGF) signalling regulates metabolism, cell growth and proliferation and diverse cell-specific processes. This Review...
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RT @NobelPrize: Some words of wisdom from this year's chemistry laureate David Baker, whose work has made it possible to design new protein….
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RT @Nature: Nature research paper: Adipose tissue retains an epigenetic memory of obesity after weight loss
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Nature - Stable epigenetic changes indicate the existence of an obesogenic memory in mouse adipocytes that primes cells for pathological responses in an obesogenic environment and potentially...
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RT @NobelPrize: "Insulin is not a cure for diabetes; it is a treatment.". - Frederick Banting in his 1923 Nobel Prize lecture. Read his ful….
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RT @NobelPrize: In May 1921, Fredrick Banting met his research assistant Charles Best in John Macleod's lab to begin their experiments with….
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RT @Nature: Researchers have created the most detailed 3D cellular map yet of a mouse embryo, visualizing close to eight million cells.http….
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RT @MolecularCell: Online Now: Structures and pH-dependent dimerization of the sevenless receptor tyrosine kinase h….
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Register now! 2025 IGF GRC registration 👉 *Participation is limited to 150!!.
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I’m excited to speak at the 2025 IGF Gordon Research Conference on March 16-21, 2025, alongside amazing experts in the IGF/insulin field. Looking forward to sharing insights and learning from others. Stay tuned for updates! #IGF #Insulin #GRC #Networking
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RT @Nature: Scientists have engineered a modified insulin that reduces its activity at low glucose levels
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Nature - Engineered insulin could overcome major problem with diabetes treatment.
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RT @arpaialab: New paper in collab w/ @tdanino lab out today in @Nature! @andrewredenti, @JongwonIm8158 and team engineer probiotic E. coli….
nature.com
Nature - Probiotic Escherichia coli Nissle 1917 is engineered as an antitumour vaccination platform optimized for enhanced production and cytosolic delivery of neoepitope-containing peptide arrays...
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- De novo agonists induce a distinct insulin receptor active conformation. - Designed agonists are more potent than insulin, reducing glucose levels longer and activating disease-causing insulin receptor mutants.
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RT @Xinru71: Now online: We created de novo insulin receptor agonists using computational protein design! @EunheeChoi12 @XiaochenB @Preetha….
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RT @NobelPrize: “I love all the proteins so I don’t want to pick favourites.". New chemistry laureate, David Baker, spoke about the technol….
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RT @NobelPrize: It's not easy to get hold of a newly awarded Nobel Prize laureate! . We are happy that chemistry laureate David Baker took….
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