Centre for Targeted Protein Degradation
@UoDCeTPD
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The Centre for Targeted Protein Degradation is an academic research centre focussing on #TPD. Part of the School of @UoDLifeSciences @DundeeUni
Dundee, UK
Joined February 2023
#OpenAccess Identification of a Highly Cooperative PROTAC Degrader Targeting GTP-Loaded KRAS(On) Alleles https://t.co/ZcINixPpmF
@UoDCeTPD @alessiociulli
pubs.acs.org
Kirsten rat sarcoma viral oncogene homologue (KRAS) is a frequently mutated oncogene in multiple types of cancer and is a high priority target for oncology drug development. There are many different...
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Identification of a Highly Cooperative PROTAC Degrader Targeting GTP-Loaded KRAS(On) Alleles | Journal of the American Chemical Society @alessiociulli
@Dundeeuni @UoDCeTPD. @AmphistaThera
pubs.acs.org
Kirsten rat sarcoma viral oncogene homologue (KRAS) is a frequently mutated oncogene in multiple types of cancer and is a high priority target for oncology drug development. There are many different...
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The Aug-Sept Journal Club is ready!! Thanks to our amazing editors: @DeLaCuadraBaste, @_nicolamurdoch, Qinghzi, and Michael. If you are interested in the latest TPD literature, have a look! https://t.co/aKKgSvEA9d
#openaccess #TPD #journalclub @UoDLifeSciences
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I am delighted to see our D2B approach for CNS-active degrader discovery is online . KH1 is identified as a rapid, potent and highly selective in vivo active chemical probe. For details: https://t.co/KFvnaxypL1
@FarnabyLab @dundeeuni @UoDCeTPD
nature.com
Nature Communications - The authors in this work identify an in vivo CNS active bifunctional degrader of GSK3. This was discovered via development of orthogonally reactive linker chemistry and a...
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Check out this lay summary style video from John Buell @Nurix_Tx explaining our work within @CancerGrand funded KOODAC team @UoDCeTPD
How do targeted protein degraders help fight childhood cancers? John Buell explains KOODAC’s work to develop safer, more effective therapies for neuroblastoma, medulloblastoma & more. Through #CancerGrandChallenges, we’re building a brighter future ➡️ https://t.co/FCwAr09iNI
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Fantastic experience attending the LITE Annual Meeting 2025 in San Francisco, as part of the @MichaelJFoxOrg initiative to accelerate therapeutic discovery in Parkinson’s disease An exciting few days of science with academic and industry partners from across the consortium!
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After an incredible 3.5 years, I recently finished my time at @UoDCeTPD, working as part of the CeTPD-Boehringer Ingelheim PROTAC collaboration team. A huge thank you to Kirsten, @farnaby84 & @alessiociulli for the opportunity to join the Team and all your guidance throughout,
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@UoDLifeSciences With this issue, we welcome Giulia as a new editor in chief joining @DeLaCuadraBaste and @Ales_Salerno in the Journal Club Team. We thank @Holmqvist89 for his contributions in the past two years. Read the issue to discover more about them!
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📖 The June-July Journal Club edition is out! Thanks to Aileen, Hiro, Ilaria and Mokhitli, great job editors! Don’t miss out on the latest news in TPD, have a look at the new edition of the Journal Club! https://t.co/0R2sI6kdzu
#openaccess #TPD #journalclub @UoDLifeSciences
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Pleased to share Dr Nur Kocaturk has been awarded a Cross-Sector Experience Award from @acmedsci This funding will allow them to collaborate with Promega Corp to co-develop a new cellular ligand finding platform for intractable disease related proteins.
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Happy to contribute to this new preprint 📖 https://t.co/KL4i37KkDn led by our 3x= contribution authors: Valentina Spiteri, Dmitri Segal, @ACorreasa as a collaboration @UoDLifeSciences and Georg E. Winter. Got to do some #cryoEM❄️🔬 @eBIC_Diamond #TPD, #DCAF16, @b45her71 🧪
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Excited to share with you our latest preprint on SMARCA2/4 degraders! at the @UoDCeTPD in collaboration with #GeorgWinter´s lab. Here, we show how a Molecular Glue Degrader can covalently and redundantly recruit DCAF16 and FBXO22 to degrade SMARCA2/4 https://t.co/DmM53sXYie
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Recruiting for a scientist with structural biology/biophysics expertise to join our KOODAC team for 12 months. Apply via https://t.co/uQ8Heh7Nm4 to join our team that use protein degradation strategies to target previously undruggable drivers of children's cancers.
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Concluded my 3-year (fixed term) contract at @UoDCeTPD (CeTPD)/@UoDLifeSciences / @dundeeuni from spring 2022 to spring 2025. I could not really describe my job the last three years, but I got to do a lot. Providing #StructuralBiology expertise, recombinant proteins, and
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The April–May CeTPD Journal Club is out! Catch up on cool new #TPD papers. Thanks Alejandro, Giulia, Mhairi & Ryan! @UoDLifeSciences
https://t.co/Siu31A7KGs
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Nice to have some visitors here in London @BirkbeckUoL Valentina and Liam from @UoDCeTPD 🏴, and UCL #NMR 🧲 facility manger @KevinHaubrich1. Had a quick peak at our ❄️🔬 #cryoEM abilities @ismb_london between users.
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Protein degraders - Alessio Ciulli (@alessiociulli) Prof @Dundeeuni @UoDCeTPD shares new insights and twists of molecular mechanism and drug design at #TETSymp. View the full program and register at https://t.co/uAGSDaXppZ
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Congratulations to all the newly elected Fellows of the @royalsociety 👏Yasmine Belkaid, @institutpasteur 👏Zhijian (James) Chen, @UTSWMedCenter @HHMINEWS 👏@alessiociulli, @dundeeuni @UoDCeTPD Read the full list: 🔗 https://t.co/Af9CCgnzms
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Tune in this Thursday for two great #TPD talks: 1) Maria Rodriguez-Rios & Conner Craigon @dundeeuni @UoDCeTPD will discuss BromoCatch 2) Mark Mabanglo & Mahmoud Noureldin @OICR_news will present DCAF1-PROTAC-WDR5 structures 👉Join us on May 29th at 12 PM EST/ 6 pm CET
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We are honoured to announce that our Director Professor @alessiociulli has been elected a Fellow of the @royalsociety (FRS), one of the highest honours for any scientist. Full story: https://t.co/rtXZ7oGYxJ
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