Ben-Sahra Lab
@bensahralab
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#biochemistry, #metabolism, #signaling, #nucleotides, Northwestern University, @NUFeinbergMed, @LurieCancer
Chicago, IL
Joined January 2017
Excited to share our latest work revealing the requirements of pyrimidine nucleotides in the control of glucose oxidation and lipogenesis published in @ScienceMagazine. Huge congratulations to co-first authors Umakant Sahu and @VillaElodie!
science.org
Evidence for UTP as a phosphate donor for thiamine pyrophosphate formation is found.
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RT @rushika_perera: Launched today- the Weill Cancer Hub West -supporting transformative cancer research collaborations btw @UCSF & @Stanfo….
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RT @LyssiotisLab: If you are in the Midwest and ❤️ metabolism, take note!. This year’s Midwest Metabolism meeting will be held jointly with….
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RT @rushika_perera: Thank you @ZouYilong and Charles David for this thoughtful commentary on our recent study connecting PCSK9 status with….
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RT @PitarresiLab: Awesome new preprint from Christine Chio's group @Chiolaboratory on the role of Iron-regulating signaling in cancer cache….
biorxiv.org
The browning and atrophy of white adipose tissue (WAT) are early events in cachexia, a lethal metabolic disorder affecting nearly half of cancer patients, including those with pancreatic ductal...
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RT @Gritsman_lab: Check out our new preprint on an epigenetic resistance mechanism to PI3 kinase inhibition in AML and a new combination th….
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RT @lab_gomes: Super excited to share our newest piece out today @NatureRevCancer linking age-induced metabolic reprogramming to cancer dev….
nature.com
Nature Reviews Cancer - In this Perspective, Lazure and Gomes argue that metabolic changes that occur as a result of ageing may shape tumour initiation and progression and the development of...
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RT @MichaelPacold: Just published: . Coenzyme Q10 (CoQ10) is critical for mitochondrial function and for controlli….
nature.com
Nature - Decreased brain coenzyme Q10 levels cause encephalopathy and are associated with neurodegeneration; supplementation with 4-HMA or 4-HB restores coenzyme Q10 synthesis in mice and humans...
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RT @gsducker: 🚨Postdoctoral position available now! 🚨We have an immediate fully funded position available in cardiac metabolism. We are lo….
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RT @DMSabatini: With @katerinarohlena pleased to announce the 2026 Prague Metabolism and Signaling Meeting (June 24-27). Two Keynotes (Vous….
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RT @EileenWhitePhD: Great story:.Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor….
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RT @RyanLab_MBU: Iron deficiency causes aspartate-sensitive dysfunction in CD8+ T cells #immunometabolism.
nature.com
Nature Communications - Iron has been shown to be necessary for the activation and differentiation of CD8+ T cells. Here the authors investigate changes in CD8+ T cell metabolism in iron limiting...
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RT @Nature: China is on course to overtake the United States as the world’s largest contributor to research.
nature.com
Nature - As China continues its scientific ascent, the rest of the world should keep engaging.
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RT @HelgasonLab: PhD opportunity (open for UK-Students only): .Interested in PhD project where you investigate environmental factors drivi….
findaphd.com
PhD Project - CRUK Scotland Centre - Investigating Asbestos exposure and other environmental factors underpinning Lung cancer inequalities in the Scottish population at University of Glasgow, listed...
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RT @ElaineFuchsLab: New paper alert! We report in @Cell_Metabolism how serine regulates skin stem cell fate. Congratulations to everyone in….
cell.com
Novak et al. discover that dietary serine impacts whether hair follicle stem cells (HFSCs) prioritize hair growth or skin repair after injury. HFSCs gauge metabolic stress using the ISR and acceler...
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RT @JustinPerryPhD: Out today from @ThePerryLab, our work suggesting how exposure to high fructose in pregnant mice or developing neonates….
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RT @JaviGBermudez: My lab's first paper is out in @Nature. We show that lipoprotein uptake protects tumors from ferroptosis by delivering t….
nature.com
Nature - Lipoprotein uptake dependent on sulfated glycosaminoglycans linked to cell-surface proteoglycans is a key determinant of ferroptosis sensitivity in cancer.
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RT @Fusion_Conf: 📣Don't forget to register and submit your abstract for short talk consideration at #RedoxBio25.The chairs would love to ha….
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RT @OlzmannLab: Happy to see our highlight out in @CurrentBiology discussing new findings related to NADH and FSP1 compartmentalization in….
cell.com
A new study identifies the aldehyde dehydrogenase ALDH7A1 as a key regulator of ferroptosis. ALDH7A1 generates a pool of membrane-associated NADH, which is used by ferroptosis suppressor protein 1 to...
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RT @YannCPhD: Excited to share our latest study from the Manning Lab. We have developed and characterized a novel mouse model lacking the f….
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RT @GabriCorso: Excited to unveil Boltz-2, our new model capable not only of predicting structures but also binding affinities! Boltz-2 is….
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