Lyssiotis Lab
@LyssiotisLab
Followers
7K
Following
15K
Media
1K
Statuses
14K
Cancer and Immune Metabolism Research Laboratory @UMRogelCancer, @UMPhysiology, @UMICHpancreas
University of Michigan
Joined November 2015
🔥Smoking hot new paper and tweetorial from @DJCalebC (collab with @ArulChinnaiyan)! 🔥 We are over the moon about this new work and its therapeutic implications for pancreatic cancer. Please have a read and share your thoughts/feedback! 🙏🏼
Beyond grateful to share that my main PhD thesis project, Targeting PIKfyve-driven lipid metabolism in pancreatic cancer (@LyssiotisLab @ArulChinnaiyan), has just been published in @Nature! @UMRogelCancer @UMICHpancreas @UMichMedSchool @UMichPath @UMichResearch @UMichCMB
13
27
126
so pleased to share our work on citrin deficiency (CD) in which we discovered G3P as the ChREBP activator, created a framework to explain FGF21, account for the beneficial effect of MCTs in CD, why urea cycle dysfunction is so severe & more @russpgoodman @MarkHermanMD @citrinfdn
5
8
31
In a recent paper, U-M researchers from @LyssiotisLab have discovered that simultaneously targeting PIKfyve and KRAS-MAPK can eliminate tumors in preclinical human and mouse models. Learn more: https://t.co/OfmZBcDac7
1
5
6
@LyssiotisLab @BarteltLab @UMich @VAInstitute @UMPhysiology @UMRogelCancer @CaymanChemical @SoleimanpourLab I was honored to present my work and be a part of such a fantastic event, @LyssiotisLab @BarteltLab @SoleimanpourLab. The organization was excellent, and the discussions were truly insightful. Hope to be involved again in the future! #MidwestMetabolism-#TRiMAD
1
1
4
There is a recent major shift in cardiology to detect high risk plaque, rather than just blockages, in order to prevent heart attacks, see @TheLancet Commission https://t.co/LmGdaXlGU7 Multiple companies @Cleerlyhealth @ElucidBio @Heartflow @CaristoHeart have different A.I.
8
89
391
The potency of the GLP-1 drugs for weight loss keeps increasing. Retatrutide is a triple receptor agonist with no clearcut plateau. There are already quadruple receptors in the pipeline. https://t.co/Y4ptCCbeFn
31
161
859
400 metabolism-minded scientists from >40 Universities converged on @UMich for our action-packed #MidwestMetabolism-#TRiMAD symposium 🧑🔬👨🔬 Thanks to co-host @VAInstitute and sponsors @UMPhysiology, @UMRogelCancer, Caswell Diabetes Ctr, Taubman Med Res Ctr, @CaymanChemical 🙏🏼
3
15
47
Today we celebrated Ahmed Elhossiny who defended his thesis, Leveraging single-cell and spatial transcriptomics data to decode pancreatic cancer progression. So proud! Congratulations Dr. Elhossiny! @Pasca_Lab @LyssiotisLab @timofran1
0
3
10
The right way to remember Jim Watson is to remember him honestly. He was a central figure in one the 20th century's most impactful scientific discoveries, in the creation of modern molecular biology, in the beginning of the genomics era, and (less notably) to shaping the
32
83
542
Congratulations to Dr. Donnele Daley of the University of Michigan Medical Center @UMichSurgery — recipient of the Karen and Josef E. Fischer International Traveling Fellowship! See Past Recipients: https://t.co/4WZo4VET46
#SSATAwards #GlobalSurgery #SurgicalExcellence
0
7
10
Revolution Medicines' Daraxonrasib (RMC-6236) - which is the only oncology therapeutic to be included in the @US_FDA National Priority Voucher program (based on #PancreaticCancer data) - is featured in @washingtonpost
https://t.co/yTBmOoTC0X cc: @break_cancer @lustgartenfdn
washingtonpost.com
Preliminary results have fueled hope for a new cancer drug from Revolution Medicines while posing a test for the Trump administration’s efforts to accelerate drug approvals.
0
8
29
New review article from @KalluriLab👇 A discussion on the status of CAFs as therapeutic targets for cancer control. Enjoy!
Online now: Insights into the relevance of targeting fibroblasts to control cancer
0
5
11
Kudos to Texans for voting in this bold new initiative - $3B in brain research — a win for patients, science, and Texas
michaeljfox.org
On November 4, 2025, Texas voters approved Proposition 14, a ballot measure that enables a historic $3 billion state investment in brain disease research over the next decade.
1
9
53
Two new Nature papers show that inhibiting FSP1 is sufficient to restrict tumor growth in vivo, a major step forward for ferroptosis-targeted cancer therapy. Huge congrats to all authors! https://t.co/ezDfPzSqvK
https://t.co/uaYWXKoi87
#Ferroptosis #FSP1 #CancerResearch
nature.com
Nature - The ferroptosis suppressor protein FSP1 has a critical role in ferroptosis protection of tumours across multiple in vivo models and is linked to worse prognosis in human lung...
2
46
174
two days until the 6th annual connecting the dots symposium on diabetes/cancer interfaces https://t.co/zSMhkN9Exr phenomenal talks in store Zobeida Cruz-Monserrate, @MuzumdarLab @LyssiotisLab Rushika Perera, Sharanya Sivanand, Paul Cohen, Rose Li & me it's free, pls register
eventbrite.com
City of Hope’s annual Diabetes & Cancer Interface Symposium explores the research and treatment links between obesity, diabetes, and cancer.
0
2
5
Our lab is expanding, we're looking for a talented postdoc-we study #glioma using in vitro and in vivo modeling, spatial transcriptomics of clinical brain tumors, and translational studies to explore DIPG and GBM resistance. #GoBlue #DefeatDIPG
4
32
90
It was such a pleasure to participate and meet the outstanding graduate students and program @unmc! Thank you so much for the visit and welcome reception 😊 Love this video, btw 🤩
Our T32 Cancer Biology Training Program recently hosted their annual Mini Symposium! Thanks to the student organizers, invited speakers @KanarekNaama @LyssiotisLab, and all attendees for an incredible event! #CancerResearch
@harvardmed @UMichMedSchool
0
0
7
After officially opening our space, Rich and Susan Rogel toured some of the labs, hearing from our amazing trainees how we're trying to hit multiple targets and use novel techniques to understand pancreatic cancer. @Pasca_Lab @timofran1 @LyssiotisLab
0
5
21