Vamsi Mootha
@VamsiMootha
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physician-scientist studying mitochondria, oxygen, bioenergetics Tweets = my own
Cambridge, MA
Joined July 2016
Kudos to Texans for voting in this bold new initiative - $3B in brain research — a win for patients, science, and Texas
michaeljfox.org
On November 4, 2025, Texas voters approved Proposition 14, a ballot measure that enables a historic $3 billion state investment in brain disease research over the next decade.
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HUGE NEWS! The FDA has approved UCB’s Kygevvi (doxecitine and doxribtimine) to treat the mitochondrial disease thymidine kinase 2 deficiency (TK2d). You can find the full prescribing details and announcement here: https://t.co/4XXSZxmD4Q
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How do dividing cells maintain mtDNA euploidy? Sharing new work by Sneha Rath that shows how the proton motive force (PMF) acts as a "puppeteer" to balance cell proliferation & mtDNA replication to maintain a stable mtDNA copy number.
biorxiv.org
Human mitochondrial DNA (mtDNA) encodes 13 essential components of the electron transport chain (ETC)[1][1]. A typical cell contains ∼1000s of copies of mtDNA, but how this copy number is stably...
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Eager to see who wins tomorrow's @NobelPrize in Biochemistry :)
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Redox-dependent liver gluconeogenesis impacts different intensity exercise in mice
nature.com
Nature Metabolism - This study shows that the preferential use of gluconeogenic pathways in the liver depends on exercise load.
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Congratulations to this year’s #LaskerAward winners! Basic: Dirk Görlich & Steven L. McKnight Clinical: Michael J. Welsh, Jesús (Tito) González, & Paul A. Negulescu Special Achievement: Lucy Shapiro https://t.co/JASQbYI0vK
#Lasker2025 #LaskerLaureate
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Could a 'little less oxygen' protect the Parkinson’s brain? A new fascinating paper just appeared in Nature Neuroscience by Marutani and colleagues. Their work challenges us to 'think deeper.' Folks, this experiment was a mouse model, so please no one put a bag over your head as
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New findings from @VamsiMootha and @fumitoichinose show low-oxygen air reverses Parkinson’s symptoms in mouse model, suggesting possible new way to treat this neurodegenerative disorder: a pill that mimics low oxygen. https://t.co/9c03dnxvku
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Hypoxia as a therapy for Parkinson's disease! New study w/ @FumitoIchinose shows PD mice have brain hyperoxia. Chronic 11% FIO2 delays neurodegeneration and *reverses* motor symptoms. Might explain why PD can improve w/altitude (thin air) or smoking (CO). https://t.co/zYrX3NHc9h
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Wow, fatty acid oxidation in neurons! Time to update the textbooks?!
A study in @NatMetabolism shows that under glucose-depleted conditions, neurons can use fatty acids as an alternative source of energy to support synaptic function. https://t.co/Z41DPxh2Fu
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Atul Butte died yesterday. The world lost a giant. A big bear of a man. With a huge smile. With love for everyone. With energy that could power a room. I loved everything about Atul. I loved how he was always happy. I loved how excited he was about science and helping people.
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Mitochondrial health is poised to become a pillar of the MAHA movement, @ahannahseo reports.
theatlantic.com
Protecting the powerhouse of the cell is a central mission of MAHA.
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Traveling can be boring, especially when you can’t reach your paid subscriptions and watch your favorite show. Just get NordVPN and unbore your journey!
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Using population and statistical genetics across 750,000 people, we have identified a putative mechanism for an important aging biomarker: the apparent age-related mtDNA mutation accrual in blood. Very excited this is up!
As we all age, we accumulate mtDNA mutations, but what underlies this hockey stick pattern? See our new pre-print: we treat mtDNA SNV burden as a "trait" and use GWAS to uncover the mechanism in blood. Led by newly minted MD-PhD @rahulg603 w/ @LabNeale. https://t.co/9OuzJKzQ8v
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Very cool work by @rahulg603 @LabNeale @VamsiMootha, and delighted to contribute. Super cool new connections between mtDNA mutational burden in blood & clonal hematopoiesis 👇
As we all age, we accumulate mtDNA mutations, but what underlies this hockey stick pattern? See our new pre-print: we treat mtDNA SNV burden as a "trait" and use GWAS to uncover the mechanism in blood. Led by newly minted MD-PhD @rahulg603 w/ @LabNeale. https://t.co/9OuzJKzQ8v
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As we all age, we accumulate mtDNA mutations, but what underlies this hockey stick pattern? See our new pre-print: we treat mtDNA SNV burden as a "trait" and use GWAS to uncover the mechanism in blood. Led by newly minted MD-PhD @rahulg603 w/ @LabNeale. https://t.co/9OuzJKzQ8v
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Wow very big news for biomedical research
Last year, $9B of the $35B that the National Institutes of Health (NIH) granted for research was used for administrative overhead, what is known as “indirect costs.” Today, NIH lowered the maximum indirect cost rate research institutions can charge the government to 15%, above
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Last year, $9B of the $35B that the National Institutes of Health (NIH) granted for research was used for administrative overhead, what is known as “indirect costs.” Today, NIH lowered the maximum indirect cost rate research institutions can charge the government to 15%, above
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Let’s not forget metabolism!
"Chance favors the prepared mind" Louis Pasteur. Yesterday I saw his house, his lab, his legacy: the germ theory of disease, vaccines, biomanufacturing, research x medicine, global public health, the French resistance, the discovery of mRNA & HIV, and on and on. So inspiring.
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Excited to share our new paper in @CellCellPress on Digital Phenotyping from Wearable Biosensors using AI to characterize Psychiatric Disorders & identify Genetic Associations (led by @JasonJLiu & @beaborsari) https://t.co/8noL0y9wqp
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@karenvaites Honestly, my takeaway from this isn't that tracking is bad, it's that teachers can't be trusted to do it right. Which, functionally, might be the same thing.
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