Vamsi Mootha
@VamsiMootha
Followers
6K
Following
2K
Media
19
Statuses
349
Professor @HarvardMed @MGH_RI @BroadInstitute @HHMINEWS interested in mitochondria, oxygen, bioenergetics. Tweets = my own.
Cambridge, MA
Joined July 2016
Wow, fatty acid oxidation in neurons! Time to update the textbooks?!.
A study in @NatMetabolism shows that under glucose-depleted conditions, neurons can use fatty acids as an alternative source of energy to support synaptic function.
4
6
52
RT @euanashley: Atul Butte died yesterday. The world lost a giant. A big bear of a man. With a huge smile. With love for everyone. With ene….
0
88
0
RT @TheAtlantic: Mitochondrial health is poised to become a pillar of the MAHA movement, @ahannahseo reports.
0
8
0
RT @rahulg603: Using population and statistical genetics across 750,000 people, we have identified a putative mechanism for an important ag….
0
1
0
RT @pnatarajanmd: Very cool work by @rahulg603 @LabNeale @VamsiMootha, and delighted to contribute. Super cool new connections between mtD….
0
6
0
As we all age, we accumulate mtDNA mutations, but what underlies this hockey stick pattern? See our new pre-print: we treat mtDNA SNV burden as a "trait" and use GWAS to uncover the mechanism in blood. Led by newly minted MD-PhD @rahulg603 w/ @LabNeale.
2
25
129
Wow very big news for biomedical research.
Last year, $9B of the $35B that the National Institutes of Health (NIH) granted for research was used for administrative overhead, what is known as “indirect costs.” Today, NIH lowered the maximum indirect cost rate research institutions can charge the government to 15%, above
3
6
25
RT @NIH: Last year, $9B of the $35B that the National Institutes of Health (NIH) granted for research was used for administrative overhead,….
0
7K
0
Let’s not forget metabolism!.
"Chance favors the prepared mind" Louis Pasteur. Yesterday I saw his house, his lab, his legacy: the germ theory of disease, vaccines, biomanufacturing, research x medicine, global public health, the French resistance, the discovery of mRNA & HIV, and on and on. So inspiring.
1
0
17
RT @MarkGerstein: Excited to share our new paper in @CellCellPress on Digital Phenotyping from Wearable Biosensors using AI to characterize….
0
24
0
Tabla legend #ZakirHussain just succumbed to idiopathic pulmonary fibrosis (IPF). RIP. I know so many Indian Americans, all in their 70s-80s, with IPF or related ILD. Has anyone else noticed this pattern? If so, what might be the mechanism? Genes? Pollution? Bird feathers?.
4
1
8
Hypoxia in a pill! . Chronic, continuous 11% FIO2 suppresses brain pathology in models of mitochondrial disease and aging, but we need practical alternatives. We combine a Hb "left-shifter" with a HIF2a inhibitor to achieve therapeutic hypoxia in mice.
1
24
115
RT @skinniderlab: Thrilled to share our approach for language model-guided discovery of unknown mammalian metabolites: DeepMet. We’ve now u….
0
28
0
RT @Denis_V_Titov: Excited to share our new paper led by @mattabolite in collaboration with Saharon Rosset showing that the Warburg Effect….
0
49
0
RT @jourdainlab: Our story on a novel pathway that controls #mitochondria from the 𝐜𝐲𝐭𝐨𝐬𝐨𝐥 and influences #immunity is now peer-reviewed an….
0
18
0
RT @LabSpiegelman: It is approaching 20 years since the passing of Stan Korsmeyer. Stan was one of the best scientists, best mentors and be….
0
4
0
Clearly, we’re now in the golden age of biology: physiology/medicine Nobel to tiny RNAs; physics Nobel to neural networks; chemistry Nobel to protein structure prediction.
3
86
481
Today's @NobelPrize for John Hopfield recognizes only one of his contributions - he's a true polymath. I strongly recommend his solo author PNAS papers (i) long-range e- tunneling in proteins (1974), (ii) kinetic proof-reading (1974), (iii) Hopfield nets (1982). Each is a gem!
1
26
185
RT @NobelPrize: BREAKING NEWS.The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the disc….
0
12K
0