Matthew Hirscheyđź’ˇ
@matthewhirschey
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academic scientist. also building @heurekalabs . like the chocolate.
Durham
Joined July 2008
Pathway coessentiality mapping reveals complex II is required for de novo purine biosynthesis in acute myeloid leukaemia
nature.com
Nature Metabolism - A machine-learning-based computational approach to probe pathway coessentiality reveals that complex II of the electron transport chain regulates de novo purine synthesis, and...
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So excited to have worked with my inspiring colleagues @matthewhirschey and @kcw00d on this study digging into the link between complex II and the purine synthesis pathway in AML!
Pathway coessentiality mapping reveals complex II is required for de novo purine biosynthesis in acute myeloid leukaemia
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The bottleneck in biology isn't literature synthesis. It's that most gene-gene functional relationships were never published. Today we're launching ARC Agent. It coordinates 17 specialized subagents with access to 40+ tools, 100M+ papers, and proprietary functional genomics
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Researchers + ARC + shared workspace = faster science. We just launched collaboration in Heureka. Teams can now work together in the same project space with ARC, sharing data, analyses, and discoveries in real time! https://t.co/f4DKv5n6ud
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2025 update shows the gene discovery situation has not gotten better...
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🤯 A Rubik’s Cube that solves itself! Inventor Takashi Kaburagi created a 3D-printed cube powered by intelligent servo motors hidden at its core—programmed to find the solution on their own. It’s fun, quirky, and brilliant. But it’s also a symbol of something much bigger. For
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[... the] process of staring hard enough with enough perseverance at the fog of muddle and confusion to eventually break through to improved clarity. https://t.co/3J7WdENW9c
andymatuschak.org
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*token usage doesn't appear to be tracking usage, because the same message was produced later in the conversation
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This is the way.
see? same pattern : - super duper expert know what the heck he’s doing - cut the project into micro functional sub tasks - feed to the llm and iterate on the context - brush up the output and ship it
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Classic @nntaleb : "The academy is dead. The real question is whether we bury it or let it stink."
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His core principle: "Stop protecting academia from volatility. The current system is fragile precisely because it's overprotected. Real intellectual life will emerge from the ruins - it already is on social media."
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5. Time-Tested + Lindy Effect - Return to medieval guild/apprentice model for crafts - Oral defenses and public disputations over peer review - Judge knowledge by longevity not novelty - "If it's not worth teaching without PowerPoint, it's not worth teaching"
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4. Via Negativa - Remove accreditation requirements - Strip out administration (return to 5-10% not 50%) - Eliminate government student loans (they enable the debt trap) - No patents from publicly-funded research
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3. Localism + Unbundling - Separate research institutes from teaching colleges from certification bodies - City-state model: small specialized schools (Venice/Singapore analogy) - Local apprenticeship for practical fields - Global online markets for pure theory
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2. Embrace Antifragility via Destruction - Let universities fail - no bailouts - Many small experimental schools instead of "too big to fail" institutions - High turnover of ideas/methods/people (remember: capitalism needs downward mobility) - Kill peer review monopoly - let
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1. Skin in the Game - Professors paid based on real-world impact, not citations - Tenure tied to producing practitioners who succeed, not papers - Academic departments that produce unemployable graduates should fail - "Would you fly in a plane designed by your engineering
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I dove into @nntaleb 's recent medium article about the shifting world and implications for understanding how we're living in it. I think asked an LLM what the antidote to this might be... Taleb's Likely Antidote to Academic Sclerosis:
not my usual topic, but it's worth taking 30+ minutes to read this. show yourself you still have the **focus and attention** and try to understand the world we're living in via @nntaleb
https://t.co/DRpl493om2
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In many cases, Academia exemplifies @nntaleb 's point about "museum-state perception" - desperately maintaining illusion of continuity while the actual learning/research ecosystem evolves elsewhere.
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