Matthew Hirschey💡
@matthewhirschey
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academic scientist. also building @heurekalabs . like the chocolate.
Durham
Joined July 2008
I asked @ChatGPTapp to make a western blot. For every few likes, I'll ask it to make it more realistic.
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Who else is in the 99% club???.
Something that is prob not known to PIs outside the US: we have to cover our salaries from grants. At med schools, usually 50-99% of it. Even teaching positions only cover 9 months salary. So you need to find ~$100-200k/year JUST for your own salary. Thus needing multiple grants.
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~coffee break.
Walker S2 replacing it's own battery. 24/7 blue-collar-worker within reach
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most of you know i'm an AI maximalist, but this is not the way 👇🏼
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Here's the full link to the paper. Fork the repo and start integrating!.
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N.B. This mosaic artwork depicts various cellular components as distinctly colored and textured pieces within a circular frame, with a dividing cell at the center surrounded by organelles and molecular structures. The image represents how the GAUDI algorithm transforms disparate.
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It's like having a tool that can look at a person's medical records, lab tests, genetic data, and lifestyle information all together to find patterns that wouldn't be obvious when looking at each piece separately.
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The key innovation is that GAUDI can detect complex, non-linear relationships (where things don't change in simple, proportional ways) better than existing methods. This helps researchers discover new biological insights and identify potential biomarkers for diseases.
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What GAUDI does:. 1. Takes all these different measurements and finds hidden patterns that connect them. 2. Groups cells that are similar across all these different measurements.Shows which specific features (like which genes or proteins) make each group unique. 3. Creates visual.
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Think of it this way:.Cells are like complex machines with many different parts -.genes (the creators),.proteins (the workers),.metabolites (the fuel and waste products),.and more. Scientists measure each of these separately, but understanding how they all work together is.
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Multi-omic data integration is hard. GAUDI is a new tool that helps scientists analyze multiple types of biological data from cells all at once.
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RT @gtdad: People—teachers, students, parents—have been complaining for a century that memorization is pointless when ”you can just look it….
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coding used to be: tab, tab, tab, tab. now coding is 1, 2, 2, 1, 1, 2.
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The deadline is JUNE 7TH. Your comment could help save American science from becoming a political weapon. Don't let them silence science. Comment NOW and RT to spread the word. 🧵.
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🚨 Every comment on Schedule F creates a LEGAL RECORD the govt must address in court. If 10,000 scientists say "this destroys research integrity" & they give a weak response? That's grounds to overturn it. One comment = one more piece of evidence they can't ignore.
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🔥 Go to: Click the green "Submit a Comment" button.Explain how politicizing grants will destroy scientific integrity.Share this thread. Every comment matters.
federalregister.gov
On April 23, 2025, the Office of Personnel Management (OPM) published in the Federal Register a notice of proposed rulemaking to increase career employee accountability. The proposed rule invited the...
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TAKE ACTION: We can fight this. The comment period is open until JUNE 7TH. By law, the government MUST respond to public comments, creating a legal record that can be challenged in court. If thousands of scientists speak up, they can't ignore that signal.
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This isn't just bad policy - it's a threat to American science.
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What this means for NIH:. - ALL Institute & Center Directors become political appointees (not just NCI).- Most/all division directors too.- Massive turnover with each administration.- Long-term research planning? Dead.- Scientific integrity? Optional.
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The most chilling part? They're targeting grant-making positions specifically:. "Substantive participation and discretionary authority in agency grantmaking. employees with a substantive discretionary role in how federal funding gets allocated". Science by political decree.
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This isn't hyperbole. The new "Schedule F" regulation would reclassify tens of thousands of federal jobs as "policymaking positions" subject to presidential appointment and removal. Translation: Fire the experts, hire the loyalists. Full proposed rule here:.
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