Avtar Singh
@avtar00_singh
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principal scientist @genentech | genomics | microscopy | biophysics
South San Francisco, CA
Joined March 2016
Excited to share our manuscript describing #OpticalPooledScreens - a new technology that enables large-scale image-based screens in mammalian cells! @CellCellPress @broadinstitute #CRISPR #microscopy.
In a study published today in @CellCellPress, scientists at the Broad and @MIT present a new image-based genetic screening method that helps researchers identify key regulators of inflammation.
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Exciting internship opportunity with Bo Li to develop deep learning methods for OPS data - please apply/share!.
Are you interested in applying deep learning skills to cutting-edge high-content perturbation screening? Apply for this internship position from my team!.
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RT @beccajcarlson: Our image-based genome-wide screen identifying new regulators of STING localization is now online at @CellSystemsCP! .ht….
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Super cool tech from @MohamadNajia @jacobborrajo Anna Le and the @BlaineyLab for cellular self-reporting! Congrats to the team!.
Excited to share how @jacobborrajo Anna Le and I are enabling the future of profiling dynamic cellular processes! We built a synthetic RNA export pathway for cells to "self-report" their transcriptional states in real-time. Big thanks to the entire team!.
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RT @BlaineyLab: We're hiring! We are seeking an exceptional postdoc associate to help us work on solving the antibiotic resistance crisis,….
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RT @JuliaBauman2: Been on a videos hiatus lately, in part bc we've been working hard to finish up our paper: . We present a method called S….
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RT @DigbijayMahat: I am excited to share a part of my postdoctoral work that came out today in @Nature. We developed a single-cell nascent….
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RT @labohaley: Published (and open access)! Super excited to share the final version of our manuscript describing an enhanced mutagenic bas….
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And awesome thread about tissue OPS from Eric:.
PerturbView enables in vivo CRISPR screens with single cell spatial resolution (. CRISPR sgRNA are uniquely identified over 6 rounds of in situ sequencing. Attached is an animation of in situ sequencing of sgRNAs in a tumor xenograft (1/4)
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Also check out this great summary from Taka:.
Our preprint on the development of PerturbView, an Optical Pooled Screening (OPS) technology, is out! Massive thanks to @eric_lubeck for driving the project with me, along with our fantastic mentors, Orit Rozenblatt-Rosen, @LeviAGarraway and Aviv Regev.1/.
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Large signal amplification also addresses challenges with in situ sequencing background and speeds up barcode readout. Super excited about this!.
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ICYMI over the holidays, amazing new PerturbView tech from @TakaKud0, @eric_lubeck, and others at @genentech. Enables OPS in diverse cell types and tissue, combined with iterative and multimodal phenotyping. Check out our preprint for more!
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Rich phenotypic profiling of genome-scale libraries by combining optical pooled screens with Cell Painting! Check out this wonderful Tweetorial by @JamesTneal and our linked preprint!.
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RT @beccajcarlson: Wow, STING is a proton channel! 🤩. This was the working title of our paper for quite awhile (emoji definitely included),….
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RT @markmccarthyoxf: A chance to postdoc in human genetics at Genentech. Our passion: using HG to help us make safe & effective drugs. Your….
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Incredible opportunity to develop and apply cutting-edge tools for spatial profiling and lineage analysis at Genentech with the ultra-talented and creative Eric Lubeck! Don't hesitate to reach out if you have any questions. And please share!.
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RT @andrewng_synbio: Exciting news - I've joined Genentech to lead the Advanced Cell Engineering Hub, and we are growing our team! We are s….
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RT @cemre_celen: Summer internship opportunity at Genentech! Come join me in identifying cellular circuits in aging & improving technologie….
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Exciting summer internship for PhD students @genentech! Develop new strategies for image based screening with an outstanding mentor - reach out to @anqiz91 for more info!.
I am hiring a 2023 summer intern at Genentech on microscopy-based image processing and statistical analysis. If you happen to be or know anyone who is interested and has relevant experience, please reach out or spread the word!.
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RT @dagarfield: Dear students and post-docs. There is a land where we will pay you for your time and you can do cool science that helps peo….
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RT @JakeFreimer: I’m hiring a computational scientist 3 at Genentech to analyze cutting-edge single-cell genomics and high-throughput scree….
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