Jacob Borrajo
@jacobborrajo
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CEO at Amber Bio. PhD @MIT. Synthetic biologist taking apart the biological world and putting it back together in new ways, for the sake of expanding health
Joined January 2018
Thrilled to share a preview of some of the exciting work happening at Amber Bio! Today we introduce a new CRISPR editing modality, Splice Editing, which enables multi-kilobase RNA edits in human cells. (1/n).
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RT @JuliaBauman2: A potentially high-efficiency alternative to making large genome edits: making large RNA edits via splicing!. Very cool pโฆ.
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RT @pablolubroth: Amber Bio pre-print alert ๐จ @jacobborrajo @themicrobeguy et al. show us how to introduce multi-Kb inserts into endogenousโฆ.
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RT @zakdoric: Hot on the heels of their Seed announcement, Amber Bio is unveiling Splice Editing โ a novel gene editing method leveraging eโฆ.
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RT @CrisprMedicine: ๐๐ฉ๐ฅ๐ข๐๐ ๐๐๐ข๐ญ๐ข๐ง๐ ๐๐ฅ๐ฅ๐จ๐ฐ๐ฌ ๐ฆ๐ฎ๐ฅ๐ญ๐ข-๐ค๐ข๐ฅ๐จ๐๐๐ฌ๐ ๐๐๐ ๐๐๐ข๐ญ๐ข๐ง๐ . Scientists from @MIT and Amber Bio share details of their new Spliceโฆ.
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RT @themicrobeguy: ๐จ Today, weโre thrilled to share our study expanding the gene editing toolbox to enable virtually any kind of edit in geโฆ.
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If you share our ethos, please visit our website (, follow us on LinkedIn, and reach out! We are currently hiring for a few roles and expanding opportunities to additional roles. Stay tuned! (7/n).
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A special thank you to our visionary investors for making this work possible @Playground_VC, @a16z, @HummingbirdVC, @pillar_vc, @EliLillyandCo, @RD_Fund, and @svangel. (6/n).
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It has been an honor to work with @themicrobeguy, @Kamyab_J, Paul Blainey, and the rest of Amber Bioโs talented team to bring this new modality to life. (5/n).
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This is the future weโre building towards at Amber Bio, and that is the imagination that led us to Splice Editing. (4/n).
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Imagine a modality that can correct thousands of bases at once in a safe, tunable, and reversible way. Imagine a future where a single formulation can overcome disease in a patient population with diverse mutations. (3/n).
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A single gene can be broken by over a thousand unique mutations in a patient population, creating challenges for current approaches which edit mutations on a guide-by-guide basis. (2/n).
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Are there any VCs/funds dedicated to AI safety? Seems wise to invest similar order of magnitude into AI safety as AI itselfโฆ I wonder what the budget gap looks like today ๐.
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RT @kulesatony: The biotech startup ecosystem is dominated by a culture that requires every executive team to have done it before. Many comโฆ.
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Amplification is to NGS, as re-reading is to single molecule proteomics ๐คฏ congrats to @cees_dekker and colleagues โ single molecule proteomics will power a new biotech revolution
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RT @schmidburgk: LAMP-Seq with 1-enzyme protocol out today grateful to colleagues @ Bonn&Boston! @k_u_ludwig @RSchโฆ.
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RT @youyanggu: Lots of people on Twitter & on the news are trying to make vaccine hesitancy political. But in fact, it's not really that pโฆ.
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RT @SGRodriques: My lab combines biotechnology and entrepreneurship to build technologies and deploy them for maximum impact. We have a posโฆ.
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RT @AhmedHBadran: Excited to share our new report in Nature Communications! We develop general engineering guidelines for building microbe-โฆ.
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