Blainey Lab
@BlaineyLab
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Official Twitter account of the Blainey Lab @broadinstitute
Cambridge, MA
Joined December 2020
RT @broadinstitute: Using an image-based screening method, Broad and Boston University researchers found potential new drug targets for red….
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Out now in @NatureMicrobiol @beccajcarlson and our lab collab w/ Rob Davey's lab @neidl on high-content image-based perturbational screening for regulators of Ebola virus infection @broadinstitute
nature.com
Nature Microbiology - A single-cell resolution image-based genome-wide CRISPR screen, analysed with deep learning and random forest models, identified host factors regulating Ebola virus infection...
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The most fun image & video creation tool in the world is here. Try it for free in the Grok App.
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RT @russelltwalton: We’re @BlaineyLab sharing a major update to CROPseq-multi, our versatile system for CRISPR screens that is compatible w….
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Out now in @CellReports our collab w/ @BiedererLab on image-based pooled genetic screening to identify regulators of synapse formation
cell.com
Le et al. performed image-based pooled CRISPR screens to elucidate mechanisms driving synapse formation. This work established a scalable approach to map functional interactions guiding the activity...
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RT @ScienceinBoston: Researchers at the @broadinstitute have created a pipeline for discovering unique combinations of molecules that incre….
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RT @jc_JulieChen: Excited to share my primary PhD work! Vibrio isolates can produce peptide deformylase inhibitors that induce prophages in….
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Recently published in @PNASNews our high-throughput screen of 1.3M+ antibiotic combos identified P2-56 as a rifampin potentiator against A. baumannii & K. pneumoniae.
pnas.org
Antibiotic resistance, especially in multidrug-resistant ESKAPE pathogens, remains a worldwide problem. Combination antimicrobial therapies may be ...
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RT @MohamadNajia: Excited to share the 1st of several stories dissecting TEs + chromatin in normal/malignant hematopoiesis. We identified h….
biorxiv.org
Genes involved in the regulation of chromatin structure are frequently disrupted in cancer, contributing to an aberrant transcriptome and phenotypic plasticity. Yet, therapeutics targeting mutant...
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Excited to see the work from @mgentili_ @beccajcarlson and others from our collab with the Hacohen lab @broadinstitute out now!.
Our image-based genome-wide screen identifying new regulators of STING localization is now online at @CellSystemsCP! .
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RT @weallen1: In collaboration with Reuben Saunders, @JswLab, and Xiaowei Zhuang, we are very excited to release Perturb-Multi: a platform….
biorxiv.org
Organ function requires coordinated activities of thousands of genes in distinct, spatially organized cell types. Understanding the basis of emergent tissue function requires approaches to dissect...
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Available now via @biorxivpreprint is our preprint on live-cell transcriptomics with engineered virus-like particles @broadinstitute
biorxiv.org
The transcriptional state of a cell provides a multi-parameter representation of gene expression programs that reflect its identity and phenotype. However, current transcriptomic profiling technolo...
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Out now in @cellcellpress - our story about metabolic differences in the vaginal microbiome led by @mzhu_ology @broadinstitute in collaboration with the @kwonlab at @ragoninstitute and others:
cell.com
Vaginal microbiota dominance by Lactobacillus iners is associated with recurrence of bacterial vaginosis (BV), a widely prevalent syndrome, whereas microbiota dominance by other Lactobacillus species...
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We're hiring for a postdoc to work with us on the technical development and deployment of optical pooled screening (OPS) technology! Details and apply here:
broadinstitute.avature.net
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We're hiring! We are seeking an exceptional postdoc associate to help us work on solving the antibiotic resistance crisis, details and apply here:
broadinstitute.avature.net
External Careers
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Now out on @biorxivpreprint! Thank you to our alum @beccajcarlson for this great Tweetorial! @broadinstitute.
I’m excited to share a new manuscript from my PhD! We performed a genome-wide optical pooled screen (OPS) and identified hundreds of novel Ebola virus regulators.
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New @biorxivpreprint! w/ our high-throughput screening approach, screened 1.3M+ antibiotic combos against high priority, drug-resistant bacterial pathogens, identified small molecule P2-56 as a potentiator of rifampin against A. baumannii and K. pneumoniae
biorxiv.org
Antibiotic resistance, especially in multidrug-resistant ESKAPE pathogens, remains a worldwide problem. Combination antimicrobial therapies may be an important strategy to overcome resistance and...
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We are excited to share our new @biorxivpreprint about CROPseq-multi with the community, many thanks to our @russelltwalton for this Tweetorial about his work with @Yue_Qin_SysBio! @broadinstitute @MITdeptofBE @Schmidt_Center.
Our new preprint describes “CROPseq-multi”: a versatile solution for multiplexed perturbation and decoding in pooled CRISPR screens Reagents on Addgene:
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RT @mzhu_ology: Excited to share our preprint on metabolic differences in the vaginal #microbiome. We find key differences in fatty acid m….
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And check out the fantastic MIT News piece by Anne Trafton about our STING paper
news.mit.edu
The immune regulatory protein STING has a previously unknown function: acting as an ion channel that allows protons to leak into cells. This discovery makes it the first human immune sensor that can...
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