Quan Xu 许泉
@_xuquan
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Postdoc @IHB_Research, computational biology, TF, GRN, single cell omics.
Basel, Switzerland
Joined December 2015
PDAC is a terrible malady and needs new inroads. We integrate a cell atlas, develop 3D tumoroid models, and map phenotypic spaces at scale. Very cool data inside! @IHB
https://t.co/nxNkT69oKN,
https://t.co/I5txaxRhUv
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We are searching for computational PhDs and Postdocs to join our group in collaboration with @TreutleinLab . We have exciting single-cell technology projects that incorporate bioengineering, computation, biology, translation. Send CV to deco_ihb@roche.com
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Congrats @_xuquan @HalleLennard et al on your @NatureGenet paper of an endoderm organoid atlas harmonizing diverse data. Exciting applications to assess fidelity, characterize perturbed and diseased states, and streamline protocol development. #OpenAccess🔗 https://t.co/9KluiflflX
Integrated Organoid Atlas benchmarks new protocols, even more impressive as a Highly Variable Cohort for comparison against perturbation and disease models: https://t.co/HntzSYo9zF Lead by @_xuquan @HalleLennard Collaboration with @fabian_theis @TreutleinLab @IHB_Research
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Thrilled to share our Human Endoderm-derived Organoid Cell Atlas (HEOCA). We compare organoids with primary tissues, assess culture strategies, and explore disease models. In collaboration with @HalleLennard, supervised by @GrayCampLab, @fabian_theis & @TreutleinLab.@IHB_Research
Integrated Organoid Atlas benchmarks new protocols, even more impressive as a Highly Variable Cohort for comparison against perturbation and disease models: https://t.co/HntzSYo9zF Lead by @_xuquan @HalleLennard Collaboration with @fabian_theis @TreutleinLab @IHB_Research
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@_xuquan @HalleLennard @TreutleinLab @fabian_theis @ETH_BSSE @IHB_Research Great open-sharing community effort @TheLutolfLab @TheSpenceLab @priscaliberali @kim_bak_jensen @BeumerJoep! Here is the link to the ms:
biorxiv.org
Human stem cells can generate complex, multicellular epithelial tissues of endodermal origin in vitro that recapitulate aspects of developing and adult human physiology. These tissues, also called...
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Excited to share our latest preprint collaboration with @HalleLennard, under the supervision of @GrayCampLab, @fabian_theis, and @TreutleinLab. We construct the first comprehensive transcriptome cell atlas of diverse organoid systems, derived from human endoderm stem cells.
55 publications, 800K+ cells: First gen. Human Endoderm Organoid Cell Atlas (HEOCA)! Intestine, lung, pancreas, liver, stomach organoids from adult and pluripotent stem cells. Great work @_xuquan @HalleLennard! @TreutleinLab @fabian_theis @ETH_BSSE @IHB_Research #organiods
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@IHB_Research is official! https://t.co/FlJuxvJanI. Super excited to be part of this unique chance to explore human biology with engineers and translational researchers at the intersection! Great city, Super team, Fun technology, Fascinating questions, Curiosity, Application!
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Welcome to the #IHBResearch Twitter channel 👋 We’re excited to be sharing news of the latest research into #Organoids and connecting with all those interested in this scientific field 🧫 Find out more about our work here ➡️ https://t.co/J8Xircw7UY
#Science #HumanModelSystems
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High-efficiency base editing for Stargardt disease in mice, non-human primates, and human retina tissue
biorxiv.org
Stargardt disease is a currently untreatable, inherited neurodegenerative disease that leads to macular degeneration and blindness due to loss-of-function mutations in the ABCA4 gene. We have...
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Really excited to present new work by @ritagonmar: we visualized the entire PubMed library, 21 million biomedical and life science papers, and learned a lot about -- THE LANDSCAPE OF BIOMEDICAL RESEARCH https://t.co/OhEx7iSjlU Joint work with @CellTypist and @benmschmidt. 1/n
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Our @Nature paper is now online: Paper: https://t.co/5BuxYHByXV Code: https://t.co/kF0TDfoe4D Data: https://t.co/sR5Tm1RnpO App: https://t.co/gWHfihK2Ta My most sincere thanks to Prof. Aviv Regev, @CarldeBoerPhD, @MIT, @broadinstitute and our collaborators
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I am delighted to announce that a draft of my latest book, “Probabilistic Machine Learning: Advanced Topics”, is now available online at https://t.co/dSlKkwYpLr. It covers #DeepGenerativeModels, #BayesianInference, #Causality, #ReinforcementLearning, #DistributionShift, etc.
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Longitudinal single-cell transcriptomics reveals distinct patterns of recurrence in acute myeloid leukemia https://t.co/AeRs65NyaL
#bioRxiv
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Last year we presented #AlphaFold v2 which predicts 3D structures of proteins down to atomic accuracy. Today we’re proud to share the methods in @Nature w/open source code. Excited to see the research this enables. More very soon! https://t.co/6uiV51Xly5
https://t.co/CLo7EKubBT
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Proud to be part of the team. Special thanks to @svheeringen @_xuquan. Great work! Congratulations to all authors @GJCVeenstra @svheeringen @_xuquan
academic.oup.com
Abstract. Proper cell fate determination is largely orchestrated by complex gene regulatory networks centered around transcription factors. However, experi
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Very excited to share my first computational paper just out in @NAR_Open. Thanks @svheeringen @JoHZhou_Lab @GJCVeenstra Georgios Siebren and @MaartenvdSande
https://t.co/FihxTe8hce
academic.oup.com
Abstract. Proper cell fate determination is largely orchestrated by complex gene regulatory networks centered around transcription factors. However, experi
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Now in @NatureMedicine: Clinical study with #optogenetic #therapy shows partial vision restoration in a blind human https://t.co/bcKSyVyY61 Collaboration to #endBlindness @IOB_ch @InstVisionParis
@Quinze_Vingts @PittTweet @StreetlabVision @GenSightBio Photo (c) V. Juvin
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Sincere thanks to our Reviewers and the editors @CellCellPress and for their time and constructive advice, and for all of the support from @ERC_Research @cziscience @IOB_ch @ETH_BSSE. There is a lot more inside, have a look! https://t.co/NI55O2jynN
https://t.co/HTbPQPi4o5
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