Lactate elevations are a hallmark of human disease, but the mechanisms regulating lactate levels remain poorly understood. Today in @Cell_Metabolism, we uncover key mechanisms of lactate homeostasis. https://t.co/DjeZQ3bZS7

Hepatocyte mitochondrial NAD+ content is limiting for liver regeneration

Excited to share my postdoc work on systemic metabolic homeostasis! We show that nutrient consumption fluxes compete, and this competitive catabolism helps explain why obesity drives diabetes. Explore our interactive web app: https://t.co/WLcglNT8xz https://t.co/7KWcrmIx56

Spatial metabolic gradients in the liver and small intestine Congratulations to Laith, Josh, and the entire team! Delighted to have been involved and contributed to this exciting study. https://t.co/13NCB0M28U

Thrilled to see this beautiful work from Haijiao Liu and Dan Huh @pennbioeng published! Congratulations to all authors - excited for what’s ahead in our collaboration.

Insights, laughter, and lactate shuttles all day. Wrapped it up with a wonderful dinner with George & Rosemary Brooks. :)

The Won Lee Lab is officially launched! Big news: yesterday we successfully set up our Exploris 480 and ran our very first metabolomics sample — a huge milestone for the lab.

Thrilled to share that my main postdoctoral project in Josh Rabinowitz’s lab is out today at @CellCellPress! We found an unexpected, diet- and microbiota-dependent mechanism that affects the anticancer activity of PI3K inhibitors. Thread below👇

Of >105,000 participants with 30-year follow-up, only 9.3% achieved healthy aging (age 70, w/o any chronic diseases). Their diet was significantly associated with this outcome🧵 @NatureMedicine

First time doing a X-tweetorial on our manuscript, be kind ! Our latest work in Nature Metabolism uncovers a striking role for glycogen accumulation in lung adenocarcinoma (LUAD) using spatial metabolomics & MALDI imaging. A thread 🧵 (1/)

Happy to share the final version of this work where we incorporated isotope labeled CO2 data into mass spec-based flux analysis framework to build a whole-body flux model of energy metabolism. Full article access here: https://t.co/aJJF3MqqNs @yuanbogeneral

Things I wish more people knew about doing science in the US (thread):

New! Online now: Lactate homeostasis is maintained through regulation of glycolysis and lipolysis https://t.co/Mlrdb2djFO

More to come as we continue to study lactate metabolism in health and disease. Stay tuned!

Shoutout to my co-mentor @PaulTitchenell and the incredible team at the Penn RMPC, led by @BaurLab.

Huge thanks to my mentor Josh and my amazing co-first author @realDRWeilandt! Grateful to all past and present Rabinowitz lab members who made this work possible—especially @tarateslaa, @Caroline_Bartma, and @cholsoon_jang, now leading their own labs.

This work builds upon the foundational contributions of many, particularly Carl and Gerty Cori (Cori Cycle) and @GeorgeABrooks3 (Lactate Shuttle), in advancing our understanding of lactate metabolism.

Key Takeaways: •Lactate & fatty acids compete for TCA oxidation •Insulin & HCAR1 promote lactate consumption by suppressing adipose lipolysis •Lactate inhibits its own production by impairing muscle insulin signaling •Kinetic model captures circuit for lactate homeostasis

Big news: Rare back-to-back studies @Nature provide evidence a bile acid called LCA mediates the health & age slowing benefits of low-calorie diets, and may be the elusive endogenous SIRT1 activator that resveratrol mimics. Details below 🧵 https://t.co/lsiepgMgkM

Nature research paper: Lithocholic acid phenocopies anti-ageing effects of calorie restriction https://t.co/6yTvEQIDtP