New data suggests that individuals whose mothers conceived during cold seasons exhibit higher BAT activity, adaptive thermogenesis, increased daily total energy expenditure and lower body mass index and visceral fat accumulation @naturemetabolism

Fascinating. Why it may be good to be conceived in the cold winter season. More brown fat (which is really good) as an adult. https://t.co/dbx5Z0QbVH https://t.co/O877iXOv8i

Using #spatialtranscriptomics and functional experiments, researchers demonstrate synergy between #neurons and #astrocytes in long-term #memoryformation. These findings elucidate the network of a memory engram. @Wenfei_Sun @StephenQuake @StanfordMed https://t.co/OZI0I4Kq7D

Excited to share a new study in @nature led by @Wenfei_Sun and in collaboration with Thomas Sudhof’s lab that maps a memory engram. It shows the interplay of neurons and astrocytes in long-term memory formation. Congrats to the team for this work.

Nature research paper: Spatial transcriptomics reveal neuron–astrocyte synergy in long-term memory

An anti-obesity GLP-1 drug restores associative learning (under dopaminergic midbrain control), as shown in a randomized trial with a single dose https://t.co/1Qqa76zHF9 @NatMetabolism

Awesome thread from @Adam_Rams (with a little help from Mariah) on our new paper looking at hippocampal memory across development. https://t.co/iOobXUgL4Q

🚨 Südhof & Quake Labs at @czbiohub created a spatial map of a long-term memory engram with #MERSCOPE! With #MERFISH they found persistent memory-associated transcriptional signatures in neurons & astrocytes in mice. Read the preprint: https://t.co/zlEK1qDPTq 🐭🧠 #NeuroTwitter

Interesting, in my hand, the dynamic range of 2NBDG was not great for cultured adipocytes.

Can cellular response to the perturbation of multiple genes be predicted? What if those genes were never perturbed experimentally? Yes! We present GEARS, a geometric deep learning model that predicts novel multi-gene perturbation outcomes 1/7🧵 Preprint: https://t.co/KjGMuEuI3U

Analysis of Single-Cell/Nucleus Transcriptome Data in Adipose Tissue.

Specialized fat cells—thermogenic adipocytes—burn excess calories to generate heat. A new #SciencePerspective reviews the process, known as adipose thermogenesis, and how it may hold the key to battling cardiometabolic diseases like type 2 diabetes. https://t.co/rRuXwhASVW

We are very excited to invite you to our symposium next month! You can find more information on our website: https://t.co/zAUKf2lHOs

Will BAT-based thermogenic medicines make it to the clinic #obesity https://t.co/Ub2E2nYKKF

Become an Admirer of Adipose! A Fan of Fat! New review in the NEJM #NEJM #NIDDK #BAT #WAT

Review | C Wolfrum, W Sun et al. (@ETH_en) discuss the heterogeneity of thermogenic adipocytes & their precursors, highlighting #singlecell technologies that help to characterize adipose tissues in depth. Great weekend read! 🤓 https://t.co/3M6kARLOlX 👉

RESEARCH | @HuaDong_, @Wenfei_Sun & the @WolfrumLab (@ETH_en) identify a regulatory pathway that inhibits #adipogenesis through RSPO2, & impairs #adipose tissue #homeostasis in mice. https://t.co/K2BLkAN98m 👉 https://t.co/RoiJlVFsTl

Online now! Cellular and molecular brakes on adipogenesis https://t.co/Z9h5m59uNC

Our paper is online❤️! R-spondin2 a member in Wnt signaling pathway inhibits new adipocyte formation and may contribute to the development of insulin resistance in obesity. Many thanks to my mentor @WolfrumLab, all the collaborators, colleagues @Wenfei_Sun and reviewers.