Sven Eyckerman
@VIBEyckermanS
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Expert Scientist @VIB, Associate Professor @UGent, Biochemistry, Signal Transduction, Protein Complexes, Proteomics, Cancer Pathways, Molecular Tinkering
Belgium
Joined April 2010
🤔How do you design a promoter for stable titration of expression? 💡Try programmable promoter editing with DIAL! 📰Now published at @NatureBiotech 🧵 [1/n] 🔗 below
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🚀🚀David Baker preprint is here!! What if we could test hundreds of designed proteins per day instead of waiting weeks for just a few dozen?@UW @biorxivpreprint "Accelerating protein design by scaling experimental characterization"(v2) • Recent advances in computational
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Super cool preprint by @Zhu_Lab @CRI_UTSW Somatic TYK2 activating mutations in tumor-infiltrating T cells promote anti-cancer immunity https://t.co/qKY8JL0VTJ Are there naturally occurring somatic mutations in lymphocytes that augment anti-tumor T cell function?
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Super excited re: first Shendure/Baker Lab collaboration & preprint on a multiplex sequencing-based strategy for screening de novo proteome editors in mammalian cells. Kudos to brilliant Chase Suiter & @Green_Ahn @UWproteindesign on the work! Preprint: https://t.co/7gh8ZtcKUO
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Fluorescent protein-based ticker tapes (FPTT) record transcriptional histories of multiple promoters on single cellular fibers. Quantitative readout is available at any time point. Cells become biological archives of their own gene expression https://t.co/vka4nksZxI
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HerTACs Enable Tumor‐Selective Lysosomal Degradation of Membrane and Extracellular Proteins via HER2 Trafficking - nice one 👏 Angewandte Chemie International Edition
onlinelibrary.wiley.com
AI-guided design of HER2-targeted lysosome-tethering chimeras (HerTACs) enables selective degradation of membrane and extracellular proteins in HER2+ tumors. These stapled peptide-based degraders...
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@SLienkamp @XenoThomasnaert @UZH_ch @MCB_Harvard @ETH_en @zkc_uzh AI meets CRISPR for precise gene editing #NBTintheNews via @UZH_en
https://t.co/AOpnwJ6TRt
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Hear Superti-Furga lab member @FabianFrommelt on our recent SLC-interactome preprint ( https://t.co/WfP74Hjj7Y) at #HUPO2024 in Dresden on Oct 21. And discuss with him his previously published DIP-MS method ( https://t.co/Vz8GkzEQg0) at poster session III (poster: 0880, Oct 23).
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📢 #JustPublished: Recent work from @SabaSays, @Seppe3sen, @KarenLeirs and @Svennetti describing how the combination of nucleic acid engineering and CRISPR can be used for innovative #biosensing concepts.🧬 👉Read: https://t.co/IQSlzjmVSu
@FWOVlaanderen @MSCActions @KU_Leuven
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Two papers from OncoRNALab out in special issue on "Bioinformatics methods to study circular RNAs" https://t.co/9s2OSf3ZHG and https://t.co/XobsP5jgIz Congrats @MariekeVromman and @AnnelienMorlion
frontiersin.org
Distinguishing circular RNA reads from reads derived from the linear host transcript is a challenging task because of sequence overlap. We developed a comput...
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Excited to have this published today:
Really excited about this new preprint from the lab on enabling ADAR mediated in vivo RNA editing using circular guide RNAs (with no co-delivery of exogenous proteins). Led by the amazing Dhruva Katrekar!
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I am delighted that, after years of collaborative and interdisciplinary efforts, our work is finally out
nature.com
Nature Communications - Full traceability and transparency are important to establish trust in engineered cell lines. Here the authors argue that version control for cell engineering marks a...
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Yesterday we had a great 'Science on the Road' edition. 50 enthusiastic children discovering microscopy. #LifeSciences, your future is secured! @Svennetti @VIBLifeSciences
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Molecular electronics sensors on a scalable semiconductor chip: A platform for single-molecule measurement of binding kinetics and enzyme activity
pnas.org
For nearly 50 years, the vision of using single molecules in circuits has been seen as providing the ultimate miniaturization of electronic chips. ...
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Efficient combinatorial targeting of RNA transcripts in single cells with Cas13 RNA Perturb-seq https://t.co/zojbOym7VQ
#bioRxiv
biorxiv.org
Pooled CRISPR screens coupled with single-cell RNA-sequencing have enabled systematic interrogation of gene function and regulatory networks. Here, we introduce Cas13 RNA Perturb-seq (CaRPool-seq)...
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Check out our report on orthogonal proteomics for binders of the lncRNA HOTAIR! Great work by @ldlhaye and his colleagues now published in @SciReports. With excellent contributions from @compomics and @pieter_mestdagh. @VIB_CMB @FWOVlaanderen
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Er is een industriebrand in de haven Port Arthurlaan. De brandweer is ter plaatste en vraagt ramen en deuren te sluiten. Als je hinder ondervindt van de rook schakel de ventilatie uit in huis of in je auto als je in de buurt bent.
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Structure of Hsp90–p23–GR reveals the Hsp90 client-remodelling mechanism:
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