Trayambak Pathak
@Trayambak_P
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Assistant Professor @LSUHealthNO and LCRC. NHLBI K99/R00 fellow. Interested in Ca2+ signaling, Metabolism, Obesity and Cancer.
NCBS/PennState/Pitt/LSU
Joined February 2015
Activity-dependent localization and dynamics of STIM1 and STIM2 at ER-PM contacts in hippocampal neurons: Cell Reports
cell.com
Chhikara et al. show that neuronal STIM proteins are highly dynamic in the ER-plasma membrane but avoid synapses. While STIM2 clusters are modulated by basal NMDAR activity, stimulation of NMDAR...
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🚨 New Cryo-EM structure of NCLX! Reveals NCLX functions as an H+/Ca2+ exchanger, not the long-assumed Na+/Ca2+ exchanger. Fascinating work! https://t.co/ljnupVQwal
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Loss of the calcium sensor #STIM2, but not of STIM1, worsens #ColorectalCancer growth and metastasis by boosting calcium ion content in the endoplasmic reticulum, remodeling mitochondria, and rewiring transcriptional activity. @TrebakM @Trayambak_P
https://t.co/DF0DZu5Jza
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Thrilled to share our latest study showing a non-canonical, SOCE-independent role of STIM2 in colorectal cancer. Explore how loss of STIM2 fuels CRC via metabolic reprogramming and ER stress activation. Huge thanks to our team @TrebakM & collaborators! https://t.co/yZ4SDNlVtM
science.org
The ER-resident Ca2+ sensor STIM2 may suppress colorectal cancer tumor progression and metastasis.
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Our first attempt to understand the dorsal endopiriform nucleus (EPd)- connectivity and functions- now published in Cell Reports. A huge thanks to Dr. Yongsoo Kim @yongsookimlab and all other lab members and colleagues who made this happen!
Brain-wide connectivity and novelty response of the dorsal endopiriform nucleus in mice
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NIH is centralizing peer review of all applications for grants, cooperative agreements and research and development contracts within the agency’s @CSRpeerreview. This is expected to save NIH more than $65 million annually & make the review process more efficient.
nih.gov
The proposed approach is expected to save more than $65 million annually.
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Free scientific illustrations for biologists! 😍 @NIH has released a library of 500+ free scientific illustrations to create figures, presentations, and illustrations! all freely available in the public domain. Retweet and spread the message! https://t.co/p1bD1kxO7H
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A fascinating study reveals how cold exposure triggers structural changes in the respiratory complex!
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Our first attempt to understand the anatomy and function of the dorsal endopiriform as a part of the claustrum complex, by @BManjila and others.
biorxiv.org
The dorsal endopiriform nucleus (EPd) is an enigmatic cortical subplate structure located inside the piriform cortex that shares a similar developmental origin with the claustrum. Although the EPd...
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We're recruiting postdocs/researchers/lab manager/technicians, doing high-resolution whole brain mapping, atlasing, neural recording, behavioral tracking, vascular mapping, etc. https://t.co/LZG0ofKFvj,
indeed.com
Penn State University College of Medicine
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“Having read ( https://t.co/Kt8cnUmxqS) and associated papers, I urge the @APSPhysiology community to join me in requesting a transparent investigation of @APS_Function editorial practices and standards. #AcademicIntegrity #OpenScience”
academic.oup.com
Over a decade ago, we showed that differentiated, contractile arterial myocytes do not express functional Ca2+ release-activated Ca2+ (CRAC) channels that
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Explore our latest article, shedding light on the non-canonical role of STIM2 in driving colorectal cancer growth and metastasis through metabolic and transcriptional reprogramming. Huge thanks to all the authors @TrebakM @NadineHempel and collaborators. https://t.co/XUa2NLE9CM
biorxiv.org
The endoplasmic reticulum (ER) stores large amounts of calcium (Ca2+), and the controlled release of ER Ca2+ regulates a myriad of cellular functions. Although altered ER Ca2+ homeostasis is known to...
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Interesting and informative read.
What do calcium and viral vectors have in common? Find out in our latest blog post!
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Fantastic study showing interaction between Gq activated IP3 mediated Ca2+ release and cAMP in GLP1 secretion. It will also be interesting to see the role of Gq activate SOCE in GLP1 secretion.
SURPRISE ! - 2.gen. GPR40 agonists stimulate cAMP through Gq and #ADCY2! - key to power endogenous #GLP_1 secretion (see👇). Seminal #GPCR @MolMetab paper by @JacobEPetersen, Maria Hauge and Mette @MTrauelsen (first senior authorship) +@Metabolcenter team https://t.co/yiBmaFnXck
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#PLOSGenetics: A STIM dependent dopamine-neuropeptide axis maintains the larval drive to feed and grow in Dro ... https://t.co/kdN9Ys015S Drosophila larvae eat constantly for 3 days - read here on what keeps them eating! @tvjayan @NCBS_Bangalore @tifr
journals.plos.org
Author summary The ability to feed appropriately when hungry is an essential feature for organismal survival and is under complex neuronal control. An array of neurotransmitters and neuropeptides...
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It’official! The #EspinosaDiezLab @cmmgwsu is recruiting 🎉🎉! If you are interested in join us or have questions about the positions, please DM or go to to positions’ links in @jobRxiv in this thread or our web https://t.co/qJeWSvfQDf 🙏🙏🙏 Please friends and colleagues RT
espinosadiezlab.com
The Espinosa-Diez lab is based in Detroit. Our group is interested in understanding how cancer therapies shape the epigenetic landscape of vascular cells, potentially giving rise to long-term...
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Interesting study by @rungtalab showing IP3R, RyR, and SOCE regulates calcium signaling in brain mid-capillary pericyte.
Pharmacology and imaging of pericytes expressing GCaMP6f uncovers the basis of Ca2+ signaling in mid-capillary brain pericytes. @Rungtalab
https://t.co/nWiU3x5sFS
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Please retweet if you can. Deadline for abstracts extended to 5/7.
#SaveTheDate: Talk #CalciumSignaling #Metabolism #TRPchannels #Cancer & more at @FASEBorg's Calcium & Cell Function Conference in Ireland, 6/25-30.#CCFSRC Abstracts Due: 4/23/2023 Info & Reg: https://t.co/V3LfLO6TeY Co-Chairs: @TrebakM & @ZhouLaboratory Keynote: @NelsonLab1
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