Ravi Rungta
@rungtalab
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Neuroscientist and Associate Professor at University of Montreal - Neurovascular Interactions
Joined January 2021
Happy to share our recent work on the spatial relationship between neuronal and vascular activity. Published today in @NatureNeuro
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📰Excited to share our latest work just published in @NatureComms Endothelial Piezo1 channel mediates mechano-feedback control of brain blood flow https://t.co/aGJPN5bbUZ 🧵
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PhD and/or Postdoc openings in our lab. Get in touch if you are at SFN and want to discuss.
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Super excited to share the first piece of work from my PhD! If you’re a fan of astrocytes, chemogenetics, and electrophysiology come check it out! https://t.co/jhDv6qpduP
biorxiv.org
Interactions between orexin neurons and astrocytes in the lateral hypothalamus influence activity levels including circadian and motivated behaviour. These behaviors are disrupted by stress in...
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🚨 Our work on neurovascular coupling and CO2 is online in @NatureComms 🥳 https://t.co/JRrCOxYrrX
nature.com
Nature Communications - A remerging hypothesis suggests that CO2 generated by neuronal metabolism contributes to neurovascular coupling (NVC). Here, the authors show that NVC is unaffected by the...
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Investigation of the spatial relationship between vascular and neuronal activity elicited by single whiskers across cortical columns and layers shows capillaries fine-tune blood flow based on distant activity and encode laminar-specific activity patterns https://t.co/vWYgOLL1kD
nature.com
Nature Neuroscience - The spatial relationship between neuronal and vascular activity remains highly debated. In this study, the authors used multiscale optical imaging to show how vascular...
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Important for understanding blood flow delivery in the brain and interpretation of high resolution hemodynamic based imaging. Huge effort by Éric Martineau, with contributions from Antoine Malescot and Nouha Elmkinssi. We hope you find it interesting; we certainly do!
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Now online our simple approach for targeted, sparse and minimally invasive delivery of #AAV by opening the #bloodbrainbarrier. Should be handy for people doing longitudinal #twophoton imaging in #cortex. Happy #FluorescenceFriday!
cell.com
Conventional methods for delivery of AAVs for in vivo imaging can be damaging and imprecise. Reeson et al. show that one can direct AAV expression to cortical cells in a targeted, minimally invasive,...
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We are very excited to share our most recent publication showing that functional hyperemia drives CSF influx and clearance in mice. https://t.co/glmOLgurLc
@Stephanie_Hol @MaiNedergaard @MichaelGiannet1 @mrfelix @VerenaUntiet @LaurenHablitz 1/9
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AQuA used to analyze pericyte activity!
Happy to share our latest work on cellular mechanisms of Ca2+ signaling in brain pericytes!!
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Interesting study by @rungtalab showing IP3R, RyR, and SOCE regulates calcium signaling in brain mid-capillary pericyte.
Pharmacology and imaging of pericytes expressing GCaMP6f uncovers the basis of Ca2+ signaling in mid-capillary brain pericytes. @Rungtalab
https://t.co/nWiU3x5sFS
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Paper is much improved and expanded since the original pre-print version, and we are very thankful to the reviewers for their contributions. Big congrats to Braxton Phillips and team on this work. Lots of exciting future directions to pursue.
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Happy to share our latest work on cellular mechanisms of Ca2+ signaling in brain pericytes!!
Pharmacology and imaging of pericytes expressing GCaMP6f uncovers the basis of Ca2+ signaling in mid-capillary brain pericytes. @Rungtalab
https://t.co/nWiU3x5sFS
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Open position in Neuroscience at UMontreal! Deadline March 31st.
jobs.sciencecareers.org
The Department of Neurosciences invites applications for a full-time faculty position at the rank of Associate or Full Professor in Neurocircuitry ...
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APPEL À COMM. #Acfasc638 Participez au colloque «La microcirculation fonctionnelle : rétine, cerveau et approches technologiques» par Elvire Vaucher, Helene Girouard, @MatthieuVanni et @rungtalab @UMontreal Date limite : 13 février 2023 👉 https://t.co/mMQ6xjvjtH
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Happy to share my paper diving into rodent pupil dynamics is now out. Being able to accurately and non-invasively sleep score with a single camera was fun. Relating Pupil Diameter and Blinking to Cortical Activity and Hemodynamics across Arousal States
jneurosci.org
Arousal state affects neural activity and vascular dynamics in the cortex, with sleep associated with large changes in the local field potential and increases in cortical blood flow. We investigated...
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Models of human #pericytes at the Anatomy Institut in Bern built in 1914 by Zimmermann. Magnification 6000x 🤩.
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The flexibility of your brain energy supply decreses with age. Our new publication in Nature Aging shows that a decrease in vascular reactivity underlies this reduction in homeostatic reserve and possibly brain frailty.
Online now! In vivo 4D #2-photon imaging study reports an age-related decrease in mouse brain microvessels responsivity, decrease in vessel density & loss of vascular mural cell process @MartinMlauritz @ChangsiCai @transneuro_lab
https://t.co/KmKvrpzMQC
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Delighted to end 2022 with our first paper out today in @CellReports, and our image on the cover! Huge congratulations to first author Ashwini Hariharan!! We show #brain #pericytes increase blood flow to decreased local energy availability to preserve energy supply to #neurons.
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Fantastic visit to uOttawa Brain and Mind yesterday! Great group doing great science. Thank you for having me and all the discussions. @SChenlab @gsilasi @JCBeique @Lab_Saghatelyan @mossy_fibers @maximewc Jing Wang, Baptiste Lacoste, Diane Legace and others!
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